Flash therapy treatment planning and oncology information system having dose rate prescription and dose rate mapping

Patent metadata

Field	Value
Publication number	US-11554271-B2
Application number	US-202117147353-A
Country	US
Kind code	B2
Filing date	Jan 12, 2021
Priority date	Jun 10, 2019
Publication date	Jan 17, 2023
Grant date	Jan 17, 2023

Abstract

A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

First claim

What is claimed is:

1. A computing system comprising:
a processor; and
memory coupled to the processor and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan, the operations comprising:
accessing a minimum prescribed dose to be delivered into and across a target;
determining a number of beams and directions of the beams, wherein each beam of the beams has a Bragg peak;
optimizing dose rate constraints for a FLASH therapy; and
displaying a dose rate map of the FLASH therapy.

2. The computing system of claim 1 , wherein access is provided to a menu that allows a selection of a desired dose rate definition.

3. The computing system of claim 2 , wherein the desired dose rate definition comprises an average field dose rate, a local dose rate, a spot dose rate, or an instantaneous dose rate.

4. The computing system of claim 2 , wherein a dose rate value can be selected after the dose rate definition is selected.

5. The computing system of claim 2 , wherein a dose rate prescription can be applied to a plurality of fields, structures, sub-structures, or groupings of voxels.

6. The computing system of claim 5 , wherein the dose rate prescription is passed through a quality assurance step, where the dose rate prescription is verified before patient treatment.

7. The computing system of claim 5 , wherein a record and verify system records a dose and a dose rate during the time of delivery.

8. A non-transitory computer-readable storage medium having computer-executable instructions for causing a computing system to perform a method of generating a radiation treatment plan, the method comprising:
accessing values of parameters from memory of the computing system, wherein the parameters comprise directions of beams, wherein each of the beams has a Bragg peak;
accessing information that specifies limits for the radiation treatment plan, wherein the limits comprise a maximum limit on irradiation time for each sub-volume outside a target;
adjusting the values of the parameters until the irradiation time for said each sub-volume outside the target satisfies the maximum limit on irradiation time;
optimizing dose rate constraints for a FLASH therapy; and
displaying a dose rate map of the FLASH therapy.

9. The non-transitory computer-readable storage medium of claim 8 , further comprising:
providing access to a menu that will allow a selection of a desired dose rate definition.

10. The non-transitory computer-readable storage medium of claim 9 , wherein the desired dose rate definition comprises an average field dose rate, a local dose rate, a spot dose rate, or an instantaneous dose rate.

11. The non-transitory computer-readable storage medium of claim 9 , further comprising:
selecting the dose rate value after the dose rate definition is selected.

12. The non-transitory computer-readable storage medium of claim 9 , further comprising:
applying a dose rate prescription to a plurality of fields, structures, sub-structures, or groupings of voxels.

13. The non-transitory computer-readable storage medium of claim 12 , further comprising:
passing the dose rate prescription through a quality assurance step, where the dose rate prescription is verified before patient treatment.

14. The non-transitory computer-readable storage medium of claim 12 , further comprising:
recording a dose and a dose rate during the time of delivery.

15. A computing system comprising:
a processor; and
memory coupled to the processor and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan, the operations comprising:
accessing a minimum prescribed dose to be delivered into and across a target;
determining a number of beams and directions of the beams, wherein each beam of the beams has a Bragg peak, and wherein the directions are determined such that the beams do not overlap outside the target and overlap inside the target;
providing a drop down menu that allows a selection of a desired dose rate definition;
optimizing dose rate constraints for a FLASH therapy; and
displaying a dose rate map of the FLASH therapy.

16. The computing system of claim 15 , wherein the desired dose rate definition comprises an average field dose rate, a local dose rate, a spot dose rate, or an instantaneous dose rate.

17. The computing system of claim 15 , wherein a dose rate value can be selected after the dose rate definition is selected.

18. The computing system of claim 15 , wherein a dose rate prescription can be applied to a plurality of fields, structures, sub-structures, and groupings of voxels.

19. The computing system of claim 18 , wherein the dose rate prescription is passed through a quality assurance step, where the dose rate prescription is verified before patient treatment.

20. The computing system of claim 18 , wherein a record and verify system records a dose and a dose rate during the time of delivery.

Assignees

• Varian Med Sys Inc
• Varian Medical Systems Int Ag
• Varian Medical Systems Particle Therapy Gmbh
• Varian Medical Systems Particle Therapy Gmbh & Co Kg

Inventors

• Smith Christel
• Koponen Timo
• Vanderstraeten Reynald
• Magliari Anthony
• Abel Eric
• Perez Jessica
• Folkerts Michael
• Khuntia Deepak

Classifications

• A61N2005/1041

  using a library of previously administered radiation treatment applied to other patients · CPC title

• A61N5/1081

  Rotating beam systems with a specific mechanical construction, e.g. gantries · CPC title

• A61N5/1045

  using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT · CPC title

• G16H50/20

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title

• G16H10/60

  for patient-specific data, e.g. for electronic patient records · CPC title