Method of continuously producing cannabidiol from cannabis plant and use thereof

Patent metadata

Field	Value
Publication number	US-11554149-B2
Application number	US-202017035690-A
Country	US
Kind code	B2
Filing date	Sep 29, 2020
Priority date	Oct 4, 2019
Publication date	Jan 17, 2023
Grant date	Jan 17, 2023

Abstract

Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

First claim

What is claimed is:

1. A method of producing cannabinoids, the method comprising irradiating microwaves to a reaction mixture comprising an extract of Cannabis sp. in ethanol in a flow-through reaction vessel, wherein the microwave irradiation is carried out while passing the reaction mixture from an inlet of the reaction vessel to an outlet of the reaction vessel, wherein the reaction vessel is contained with a reaction chamber filled with a fluid to maintain a temperature of the reaction medium in a range from 80° C. to 100° C.,
wherein the extract includes cannabidiolic acid and the microwave irradiation is carried out for a time sufficient to convert the cannabidiolic acid to cannabidiol with a CBD yield of at least 84.7% and a CBD content % of at least 90.3%.

2. The method of claim 1 , further comprising isolating cannabinoids from the microwave-irradiated reaction mixture.

3. The method of claim 1 , wherein the extract is obtained by a method comprising contacting the Cannabis sp. plant with one or more of water, a protonic solvent, an aprotonic solvent, and a mixture thereof.

4. The method of claim 1 , wherein the Cannabis sp. plant comprises leaves, flower buds, fruits, trichomes, flower bracts, stems, or any part comprising cannabinoids.

5. The method of claim 1 , wherein the microwave irradiation is carried out for about 5 minutes to about 180 minutes.

6. The method of claim 1 , wherein the microwave irradiation is carried out under pressure.

7. The method of claim 1 , wherein the microwave irradiation is carried out at a frequency of 300 MHz to 300 GHz.

8. The method of claim 1 , wherein the microwave irradiation is carried out at a power of 3 W to 6 kW.

9. The method of claim 1 , wherein the reaction vessel is made of a microwave-transparent material.

10. The method of claim 1 , wherein the reaction chamber comprises a microwave-transparent material.

11. The method of claim 1 , wherein the microwave irradiation is carried out for a time sufficient to convert the cannabidiolic acid to cannabidiol with a CBD yield of at least 90.4% and a CBD content % of at least 93.1%.

Assignees

• Korea Inst Sci & Tech

Inventors

• Ham Jungyeob
• Kim Taejung
• Chung Bong Chul
• Lee Seok
• Song Bong Geun
• Ha Sungdo
• Park Young Tae
• Choi Pilju
• Ryu Hoon

Classifications

• B01J19/126

  Microwaves · CPC title

• A61K8/347

  Phenols · CPC title

• C07C39/23

  polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings · CPC title

• B01D3/40

  Extractive distillation · CPC title

• A61K2236/333

  using mixed solvents, e.g. 70% EtOH · CPC title