Method for producing radioactive composition

Patent metadata

Field	Value
Publication number	US-11548004-B2
Application number	US-202117317273-A
Country	US
Kind code	B2
Filing date	May 11, 2021
Priority date	May 19, 2020
Publication date	Jan 10, 2023
Grant date	Jan 10, 2023

Abstract

A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet L1 containing a radionuclide and at least one second droplet L2 containing a labeling substance on at least two respective dimples 5 among dimples 5 on a front surface 4b of an insulating layer 4 of a liquid manipulation device 1, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodes 3 to thereby cause a relative movement between the at least one first droplet L1 and the at least one second droplet L2 so that the at least one first droplet L1 and the at least one second droplet L2 are mixed together at any one dimple among the dimples 5.

First claim

What is claimed is:

1. A method for producing a radioactive composition using a liquid manipulation device,
the device comprising:
a substrate;
electrodes located on a front surface of the substrate; and
an insulating layer located on the front surface of the substrate to cover the electrodes,
the insulating layer having a back surface facing the front surface of the substrate and a front surface located opposite the back surface of the insulating layer with respect to a thickness direction of the insulating layer, the insulating layer including dimples at locations corresponding to respective locations of the electrodes, the dimples being curved concave in a concave direction directed from the front surface of the insulating layer toward the back surface of the insulating layer, each of the electrodes including a dimple-corresponding portion curved concave in the concave direction together with one of the dimples at a corresponding location,
the production method comprising:
placing at least one first droplet containing a radionuclide and at least one second droplet containing a labeling substance on at least two respective dimples among the dimples on the front surface of the insulating layer; and
obtaining a liquid mixture by using a change in electrostatic force caused by changing voltage applied to the electrodes to thereby cause a relative movement between the at least one first droplet and the at least one second droplet so that the at least one first droplet and the at least one second droplet are mixed together at any one dimple among the dimples.

2. The method for producing a radioactive composition according to claim 1 , further comprising stirring the liquid mixture by using a change in the electrostatic force to thereby cause a movement of the liquid mixture between two adjacent dimples among the dimples at least once.

3. The method for producing a radioactive composition according to claim 1 , wherein the first droplet contains a radionuclide selected from 99m Tc, 111 In, 67 Ga, 123 I, 68 Ga, 64 Cu, 89 Zr, 18 F, 63 Zn, 44 Sc, 124 I, 90 Y, 223 Ra, 211 At, 225 Ac, 177 Lu, 131 I, and 89 Sr.

4. The method for producing a radioactive composition according to claim 1 , wherein, in the placing, at least one third droplet containing a pH adjuster is also placed on at least one dimple among the dimples, the at least one dimple being different from the at least two respective dimples at which the at least one first droplet and the at least one second droplet are placed, and
in the obtaining the liquid mixture, by using a change in the electrostatic force, a relative movement is caused between the at least one first droplet, the at least one second droplet, and the at least one third droplet so that the at least one first droplet, the at least one second droplet, and the at least one third droplet are mixed together at any one dimple among the dimples.

Assignees

• Aist
• Kyoto Pharmaceutical Univ

Inventors

• Mogi Katsuo
• Natsume Tohru
• Adachi Shungo
• Inoue Tomoya
• Kimura Hiroyuki

Classifications

• B01L2300/0851

  Bottom walls · CPC title

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• B01L2300/165

  Specific details about hydrophobic, oleophobic surfaces · CPC title

• B01L2300/0829

  Multi-well plates; Microtitration plates · CPC title

• B01L2300/0819

  Microarrays; Biochips · CPC title