Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices

Patent metadata

Field	Value
Publication number	US-11547766-B2
Application number	US-202117331990-A
Country	US
Kind code	B2
Filing date	May 27, 2021
Priority date	Feb 21, 2014
Publication date	Jan 10, 2023
Grant date	Jan 10, 2023

Abstract

Systems, methods and related devices used to produce and collect polarized noble gas to inhibit, suppress, detect or filter alkali metal nanoclusters to preserve or increase a polarization level thereof. The systems can include a pre-sat chamber that has an Area Ratio between 20 and 500.

First claim

That which is claimed is:

1. A method for producing hyperpolarized 129 Xe, comprising:
generating hyperpolarized 129 Xe gas using spin-exchange optical pumping with a continuous flow through an optical pumping cell over a defined production period; and
suppressing generation of alkali nanoclusters below 1×10 9 per cm 3 during the generating.

2. The method of claim 1 , wherein the defined production period is in a range of 10-60 minutes.

3. The method of claim 1 , where the alkali nanocluster suppression is carried out to suppress at least one of Rb, Cs, Na, and K nanoclusters, and/or any combination thereof.

4. The method of claim 1 , further comprising pre-saturating a noble gas mixture with vaporized alkali metal in a pre-saturation chamber having an Area Ratio (AR) of between 20 and about 500 and residing outside a laser exposure region of an optical pumping laser associated with the optical pumping cell, then flowing the noble gas mixture with the vaporized alkali metal into the optical pumping cell for the generating step.

5. The method of claim 4 , wherein the AR is between 20 and 200.

6. The method of claim 5 , wherein the AR is about 100.

7. The method of claim 1 , further comprising sealably attaching a pre-saturation chamber with alkali metal in an amount in a range of about 0.5 grams and 5 grams to a manifold upstream of the optical pumping cell prior to the generating step.

8. The method of claim 1 , further comprising during the generating step, electronically monitoring for nanocluster generation in the optical pumping cell.

9. The method of claim 1 , further comprising filtering nanoclusters from the generated hyperpolarized gas.

10. The method of claim 1 , further comprising collecting at least one bolus amount of the hyperpolarized 129 Xe gas in a bag for inhalation delivery to the patient, wherein the bag is releasably coupled to an accumulator positioned downstream of the continuous flow optical pumping cell.

11. The method of claim 1 , wherein the optical pumping cell comprises an internal coating comprising one or more of polydimethylsiloxanes, paraffins, or a coating selected to hold up to alkali metals and provide ballistic impact reduction and/or control to suppress alkali metal cluster formation.

12. The method of claim 11 , wherein the internal coating comprises one or more of: a siloxane, a fluorinated and/or deuterated siloxane, a silane, a fluorinated and/or deuterated silane, a polydialkylsiloxane, a fluorinated and/or deuterated polydialkylsiloxane, a polyalkylarylsiloxane, a fluorinated and/or deuterated polyalkylarylsiloxane, a polydiarylsiloxane, a fluorinated and/or deuterated polydiarylsiloxane, a polyheteroorganosiloxane, a fluorinated and/or deuterated polyheteroorganosiloxane, a paraffin, a deuterated and/or fluorinated paraffin, a hydrocarbon wax, a deuterated and/or fluorinated hydrocarbon wax, and any combination thereof.

13. A method of producing hyperpolarized noble gas, comprising:
providing a flow through hyperpolarizer comprising a pre-saturation chamber upstream of an optical pumping cell, wherein the pre-saturation chamber comprises alkali metal and has an Area Ratio (AR) in a range of about 20 and 500;
flowing a gas mixture comprising a noble gas through the pre-saturation chamber then through the optical pumping cell whereby hyperpolarized noble gas is produced; and
collecting at least one bolus amount of hyperpolarized noble gas at an exit port thereof and/or downstream of the optical pumping cell.

14. The method of claim 13 , further comprising heating the pre-saturation chamber to a first temperature and the optical pumping cell to a different second temperature before and/or during the flowing.

15. The method of claim 14 , wherein the heating is carried out to apply heat to the pre-saturation chamber in a range of 140 Celsius and 300 Celsius.

16. The method of claim 14 , wherein the heating is carried out to heat the optical pumping cell to a temperature that is less than the pre-saturation chamber.

17. The method of claim 13 , wherein the alkali metal comprises Rb, wherein the noble gas mixture comprises 129 Xe gas, and wherein the hyperpolarized noble gas comprises hyperpolarized 129 Xe.

18. The method of claim 13 , wherein the at least one bolus amount of the hyperpolarized noble gas is hyperpolarized 129 Xe gas that is collected in a bag coupled to an accumulator in fluid communication with and downstream of the optical pumping cell for inhalation delivery to a patient.

19. The method of claim 13 , further comprising attaching the pre-saturation chamber to a conduit upstream of the optical pumping cell prior to the flowing.

20. The method of claim 13 , wherein the pre-saturation chamber has an AR that is between 20 and 200.

21. The method of claim 20 , wherein the AR is about 100.

22. The method of claim 13 , wherein a new and/or previously unused pre-saturation chamber comprises rubidium (Rb) in a range of about 0.5 and 5 grams.

Assignees

• Univ Duke

Inventors

• Freeman Matthew S
• Driehuys Bastiaan

Classifications

• C01B23/00

  Noble gases; Compounds thereof (liquefying F25J {; noble gases obtained by rectification F25J3/028}) · CPC title

• A61K49/106

  the complex-forming compound being cyclic, e.g. DOTA · CPC title

• A61K49/06 Primary

  Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations · CPC title

• G01R33/282

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• A61K49/18 Primary

  characterised by a special physical form, e.g. emulsions, microcapsules, liposomes · CPC title