Composition for preventing, ameliorating or treating sleep disorders comprising medicinal herb extract as effective ingredient

Patent metadata

Field	Value
Publication number	US-11541088-B2
Application number	US-201917058861-A
Country	US
Kind code	B2
Filing date	May 23, 2019
Priority date	May 25, 2018
Publication date	Jan 3, 2023
Grant date	Jan 3, 2023

Abstract

A method for treating a sleep disorder according to an embodiment of the present disclosure includes administering a composition comprising an extract of Hibiscus syriacus as an effective ingredient to a subject in need thereof. Because the Hibiscus syriacus extract of the present invention has an effect of improving sleep time deteriorated by stress, and an effect of reducing the content of corticosterone, which increases due to stress, and increasing the content of serotonin in blood. In addition, the composition has an effect of enhancing in a significant sense the expression of GABAR A α1 in cerebral cortex, which decreases due to stress, in a group administered with Hibiscus syriacus extract. As such, the composition comprising Hibiscus syriacus extract as an effective ingredient as an effective ingredient can be advantageously used as a functional health food composition or a pharmaceutical composition for preventing, ameliorating or treating sleeping disorders.

First claim

What is claimed is:

1. A method for treating insomnia, the method comprising:
administering a composition comprising an extract of Hibiscus syriacus flower as an effective ingredient to a subject in need thereof,
wherein the extract of Hibiscus syriacus flower is an extract extracted with an ethanol solution;
the insomnia is caused by an increased wake and a reduced REM (Rapid eye movement) sleep and NonREM (Non-Rapid eye movement) sleep during sleeping; and
the extract of Hibiscus syriacus flower reduces wake and increases REM (Rapid eye movement) sleep and NonREM (Non-Rapid eye movement) sleep during sleeping to improve sleep quality.

2. The method of claim 1 , wherein the composition is in a formulation selected from the group consisting of a powder, a granule, a pill, a tablet, a capsule, a candy, a syrup, and a drink.

3. The method of claim 1 , wherein the composition is included in a health food.

4. The method of claim 1 , wherein the composition is a pharmaceutical composition.

5. The method of claim 4 , wherein the pharmaceutical composition further comprises at least one of a pharmaceutically acceptable carrier, a pharmaceutically acceptable vehicle, or a diluent.

Assignees

• Korea Inst Oriental Medicine

Inventors

• Lee Mi Young
• Kim Yu Ri
• Park Bo-Kyung
• Kim Young Hwa

Classifications

• A61P25/20 Primary

  Hypnotics; Sedatives · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K2236/333

  using mixed solvents, e.g. 70% EtOH · CPC title

• A23V2200/322

  having an effect on the health of the nervous system or on mental function · CPC title

• A23L33/105 Primary

  Plant extracts, their artificial duplicates or their derivatives · CPC title