Fortified micronutrient salt formulations

Patent metadata

Field	Value
Publication number	US-11541017-B2
Application number	US-201715484892-A
Country	US
Kind code	B2
Filing date	Apr 11, 2017
Priority date	Dec 16, 2013
Publication date	Jan 3, 2023
Grant date	Jan 3, 2023

Abstract

Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

First claim

We claim:

1. A formulation comprising:
particles comprising one or more types of micronutrient agents dispersed in a polymer matrix formed of a pH-sensitive water-insoluble polymethacrylate polymer comprising dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate,
the pH-sensitive water-insoluble polymer dissolving at a pH less than 6.0,
wherein the polymer matrix is sufficiently non-porous such that water or other aqueous media cannot diffuse through the polymer matrix and dissolve the one or more types of micronutrient agents and the polymer matrix stabilizes the agents by preventing oxidation of air-sensitive agents for a period of weeks,
wherein the polymer matrix has a thermal stability to 100° C. for thirty minutes and the one or more types of micronutrient agents are released from the polymer matrix upon exposure to a defined pH of less than 6.0, and
wherein the polymer matrix contains the pH-sensitive water-insoluble polymer in an amount such that the polymer matrix resists degradation in an aqueous solution at a pH of about 7.4 for about one hour.

2. The formulation of claim 1 , wherein the one or more types of micronutrient agents are selected from the group consisting of vitamins, trace minerals, and combinations thereof.

3. The formulation of claim 2 , wherein the vitamins and trace minerals are selected from the group consisting of iron, zinc, manganese, copper, iodine, selenium, molybdenum, chromium, vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B9 (folic acid), vitamin B12, vitamin C, vitamin D3, vitamin E, vitamin K, pantothenic acid, biotin, and combinations thereof.

4. The formulation of claim 2 , wherein the one or more types of micronutrient agents are selected from the group consisting of potassium iodide, phosphates, and combinations thereof.

5. The formulation of claim 1 , wherein the polymer matrix dissolves at a pH between about 1 and 5, about 1 and 3, or about 1 and 2.

6. The formulation of claim 1 , wherein the polymer matrix dissolves at a pH between about 5 and 6.

7. The formulation of claim 1 , wherein the pH-sensitive polymer is poly(butylmethacrylate)-co-(dimethylaminoethyl)methacrylate-co-(methylmethacrylate) (1:2:1 ratio).

8. The formulation of claim 1 , wherein the pH-sensitive polymer forms salts at a pH less than 6.0.

9. The formulation of claim 1 , wherein the polymer matrix has a surface coating comprising salts, sugar, or other coating material.

10. The formulation of claim 9 , wherein the surface coating comprises chitosan.

11. The formulation of claim 1 , wherein the particles have a diameter of one millimeter or less.

12. The formulation of claim 1 , wherein the polymer matrix modulates release of the one or more types of micronutrient agents from the particles upon exposure to a defined pH between about pH 1 and 3.

13. The formulation of claim 1 , wherein the particles are formulated in a feed for administration to animals.

14. The formulation of claim 1 , wherein the particles are formulated with food.

15. The formulation of claim 1 , wherein the polymer matrix is a solid.

16. A method of providing micronutrients, the method comprising adding an effective amount of the particles of claim 1 to a food.

17. The method of claim 16 , wherein the formulation is provided to agricultural animals.

Assignees

• Massachusetts Inst Technology
• Tokitae Llc

Inventors

• Jaklenec Ana
• Xu Xian
• Wood Jr Lowell L
• Welkhoff Philip A
• Gates William
• Nikolic Boris
• Langer Robert S

Classifications

• A61K33/30

  Zinc; Compounds thereof · CPC title

• A61K9/501

  Inorganic compounds · CPC title

• A61K31/519 Primary

  ortho- or peri-condensed with heterocyclic rings · CPC title

• A23L33/16

  Inorganic salts, minerals or trace elements · CPC title

• A61K31/375

  Ascorbic acid, i.e. vitamin C; Salts thereof · CPC title