Hybrid multiferroic nanoparticles as MRI contrast agent for sensing of electric fields in a human body

Patent metadata

Field	Value
Publication number	US-11536789-B2
Application number	US-202016893047-A
Country	US
Kind code	B2
Filing date	Jun 4, 2020
Priority date	Jun 4, 2019
Publication date	Dec 27, 2022
Grant date	Dec 27, 2022

Abstract

An apparatus includes a plurality of particles, wherein each particle contains a plurality of magnetizable (for example, ferromagnetic) and ferroelectric materials in fixed physical relationship (for example, physical contact) with one another. A method and apparatus measure magnetic fields arising from or within the plurality of particles.

First claim

The invention claimed is:

1. An apparatus for measuring electric fields in a structure, the apparatus comprising:
a plurality of particles, wherein each particle contains component materials with magnetizable and ferroelectric properties, and the component materials are in fixed relative positions to one another; and
an instrument sensitive to magnetic fields or to changes of magnetic fields, wherein the instrument is configured to detect change in magnetizations of one or more magnetizable components of the plurality of particles when one or more ferroelectric components in the plurality of particles rotate when exposed to an externally-applied electric field.

2. The apparatus of claim 1 , wherein the plurality of particles have been administered to a living being.

3. The apparatus of claim 1 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetic resonance imaging device.

4. The apparatus of claim 1 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetometer.

5. The apparatus of claim 1 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetic particle imaging instrument.

6. The apparatus of claim 1 , wherein the plurality of particles are each made of a material with both magnetic and ferroelectric properties that act as if the particles were made of separate magnetic and ferroelectric components.

7. The apparatus of claim 1 , wherein each of the plurality of particles are coated with a material that enables rotation of one or more components in a particle or of an entire particle.

8. A method of measuring electric fields in a structure, the method comprising:
introducing a plurality of particles into or upon the structure, each the particle containing component materials with magnetizable and ferroelectric properties, wherein the component materials in fixed relative positions to one another; and
detecting, using an instrument sensitive to magnetic fields or to changes of magnetic fields, a change in magnetizations of one or more magnetizable components of the plurality of particles when one or more ferroelectric components in the plurality of particles rotate when exposed to the electric fields within the structure.

9. The method of claim 8 , wherein the magnetic properties of the magnetizable components of the particles are used to transport the particles into or within a structure.

10. The method of claim 8 , wherein the structure is a body part in a living organism and the instrument collects multiple images that reflect anatomy of the body part and also electric fields within the body part.

11. The method of claim 8 , further comprising using the spin decay of protons near particles to assess the magnetization state of the particles.

12. The method of claim 8 , wherein the plurality of particles have been administered to a living being.

13. The method of claim 8 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetic resonance imaging device.

14. The method of claim 8 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetometer.

15. The method of claim 8 , wherein the instrument sensitive to magnetic fields or to changes in magnetic fields is a magnetic particle imaging instrument.

16. The method of claim 8 , wherein the plurality of particles are each made of a material with both magnetic and ferroelectric properties that act as if the particles were made of separate magnetic and ferroelectric components.

17. The method of claim 8 , wherein each of the plurality of particles are coated with a material that enables rotation of one or more components in a particle or of an entire particle.

Assignees

• Weinberg Medical Physics Inc

Inventors

• Weinberg Irving
• Mair Lamar Odell
• Udalov Oleg

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/5601 Primary

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• G01R33/1276

  of magnetic particles, e.g. imaging of magnetic nanoparticles (G01R33/1269 takes precedence) · CPC title

• B82Y25/00

  Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance · CPC title

• A61B5/0515

  Magnetic particle imaging · CPC title