Methods for treatment and diagnosis of cancer by targeting glycoprotein a repetitions predominant (garp) and for providing effective immunotherapy alone or in combination
US-2019127483-A1 · May 2, 2019 · US
Sickled beta globin antibodies
US11535681B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11535681-B2 |
| Application number | US-201816771411-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 14, 2018 |
| Priority date | Dec 15, 2017 |
| Publication date | Dec 27, 2022 |
| Grant date | Dec 27, 2022 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention generally provides improved anti-sickled-globin antibodies and fragments thereof. In particular embodiments, the antibody or antigen binding fragment thereof recognizes the βs, Glu6Val mutation. In various embodiments, the invention provides a conjugate comprising an anti-βs-globin antibody or antigen binding fragment thereof and a detectable label. In particular embodiments, a hybridoma comprising an anti-βs-globin antibody contemplated herein is provided.
First claim
Opening claim text (preview).
The invention claimed is: 1. An anti-β S globin antibody or antigen binding fragment thereof that binds a human βS globin polypeptide, wherein the anti-β S globin antibody or antigen binding fragment thereof comprises a variable light chain sequence as set forth in SEQ ID NO: 7 and a variable heavy chain sequence as set forth in SEQ ID NO: 8. 2. A conjugate, comprising the anti-β S globin antibody or antigen binding fragment thereof of claim 1 ; and a detectable label. 3. The conjugate of claim 2 , wherein the detectable label is selected from the group consisting of: a hapten, a fluorescent dye, a fluorescent protein, a chromophore, a metal ion, a gold particle, a silver particle, a magnetic particle, a polypeptide, an enzyme, a luminescent compound, or an oligonucleotide. 4. A hybridoma comprising the anti-β S globin antibody of claim 1 . 5. A polynucleotide encoding the anti-β S globin antibody or antigen binding fragment thereof of claim 1 .
Assignees
Inventors
Classifications
Single chain antibody (scFv) · CPC title
Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues · CPC title
Complementarity determining region [CDR] · CPC title
- C07K16/34Primary
against blood group antigens · CPC title
Haemoglobin · CPC title
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Frequently asked questions
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- What does patent US11535681B2 cover?
- The invention generally provides improved anti-sickled-globin antibodies and fragments thereof. In particular embodiments, the antibody or antigen binding fragment thereof recognizes the βs, Glu6Val mutation. In various embodiments, the invention provides a conjugate comprising an anti-βs-globin antibody or antigen binding fragment thereof and a detectable label. In particular embodiments, a hy…
- Who is the assignee on this patent?
- Bluebird Bio Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K16/34. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).