Photoreactive ligands and uses thereof

Patent metadata

Field	Value
Publication number	US-11535597-B2
Application number	US-201816478444-A
Country	US
Kind code	B2
Filing date	Jan 17, 2018
Priority date	Jan 18, 2017
Publication date	Dec 27, 2022
Grant date	Dec 27, 2022

Abstract

Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.

First claim

What is claimed is:

1. A small molecule ligand having a structure represented by Formula (I):

wherein R is

and wherein the wavy lines indicate linkage to the carbonyl group of the structure of Formula (I).

2. A small molecule ligand which binds to a ligand binding site of Cathepsin B (CTSB), the small molecule ligand is, selected from the group consisting of

3. The small molecule ligand of claim 2 , wherein the ligand binding site is defined by the following residues: GQDHCGIESEVVAGIPR of the CTSB protein having the UniProtKB accession number P07858.

Assignees

• Scripps Research Inst

Inventors

• Cravatt Benjamin F
• Parker Christopher G
• Correia Bruno

Classifications

• C07D229/02 Primary

  containing three-membered rings · CPC title

• G01N1/44

  Sample treatment involving radiation, e.g. heat · CPC title

• C07D403/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07D401/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07D405/12

  linked by a chain containing hetero atoms as chain links · CPC title