Manufacturing method of plate precursor having needle-like protrusion, and manufacturing method of microneedle array
US-2020114547-A1 · Apr 16, 2020 · US
US11534943B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11534943-B2 |
| Application number | US-202016807181-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 3, 2020 |
| Priority date | Mar 5, 2019 |
| Publication date | Dec 27, 2022 |
| Grant date | Dec 27, 2022 |
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A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.
Opening claim text (preview).
What is claimed is: 1. A manufacturing method of a pattern sheet comprising: producing a mold having a recessed pattern in a recessed step portion, wherein a production method of the mold, comprising: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern formed by a plurality of protruding portions is disposed; a resin plate preparation step of preparing a thermoplastic resin plate in which a recessed step portion having a bottom surface and a wall surface is formed on a flat surface thereof, the recessed step portion having a volume equal to or less than a total volume of the protruding pattern and the pedestal; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, after the resin plate preparation step, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion by moving the plate precursor and the thermoplastic resin plate relative to each other, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the bottom surface of the recessed step portion, wherein a protrusion surrounding the recessed step portion is correspondingly formed on a main surface of the thermoplastic resin plate, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate, a step of supplying a liquid material to the recessed step portion of the mold to fill the recessed pattern of the mold with the liquid material; a step of solidifying the liquid material to form a pattern sheet having a protruding pattern; and a releasing step of releasing the pattern sheet from the mold. 2. The manufacturing method of a pattern sheet according to claim 1 , wherein the pattern sheet is a microneedle array. 3. The manufacturing method of a pattern sheet according to claim 1 , wherein the liquid material is a polymer solution. 4. The manufacturing method of a pattern sheet according to claim 3 , wherein the polymer solution contains a water-soluble material.
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