Drug-filled synthetic resin ampule and synthetic resin ampule body used for same

Patent metadata

Field	Value
Publication number	US-11534370-B2
Application number	US-202017028311-A
Country	US
Kind code	B2
Filing date	Sep 22, 2020
Priority date	Mar 23, 2018
Publication date	Dec 27, 2022
Grant date	Dec 27, 2022

Abstract

A drug-filled synthetic resin ampule includes an ampule body and a drug 8 filled in the ampule body. The ampule body includes a tip-side sealing portion, a hollow portion, and an annular breakable portion provided between the tip-side sealing portion and the hollow portion. The tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof, and an internal ceiling portion exposed to the interior of the hollow portion. The breakable portion includes an annular smallest diameter portion, and the smallest diameter portion is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion.

First claim

The invention claimed is:

1. A drug-filled synthetic resin ampule comprising
a hollow ampule body, a lower-end-side sealing member for sealing a lower end of the hollow ampule body, and a drug filled in the hollow ampule body;
wherein the hollow ampule body includes a tip-side sealing portion, a hollow portion located below the tip-side sealing portion and having a drug containing portion therein, and an annular breakable portion provided at a lower portion of the tip-side sealing portion;
the tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof and an internal ceiling portion exposed to an interior of the hollow portion;
the annular breakable portion includes an annular smallest diameter portion which is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion;
the internal ceiling portion has a flat portion located radially inward of the annular circumferential edge portion and below the annular breakable portion;
the hollow ampule body has a diameter reducing portion that reduces in outer and inner diameter toward the annular breakable portion; and
the annular breakable portion has a thin weak portion located at an upper end portion of said diameter reducing portion and located between the annular smallest diameter portion and the annular circumferential edge portion.

2. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular smallest diameter portion is an annular smallest diameter portion formed to have an acute angle.

3. A drug-filled synthetic resin ampule according to claim 1 , wherein an upper portion of the hollow portion gradually decreases in wall thickness toward the smallest diameter portion of the annular breakable portion.

4. A drug-filled synthetic resin ampule according to claim 1 , wherein the ampule is broken at the annular breakable portion as a result of the flat plate portion for grasping of the tip-side sealing portion being grasped and twisted.

5. A drug-filled synthetic resin ampule according to claim 1 , wherein the hollow ampule body includes a bottom plate member for sealing a lower end opening of the hollow portion.

6. A drug-filled synthetic resin ampule according to claim 1 , wherein the hollow ampule body is formed of a hard or semi-hard synthetic resin material through injection molding.

7. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular smallest diameter portion is an annular smallest diameter portion formed to have an acute angle, and the annular breakable portion has an angle of 30° to 90° at the smallest diameter portion.

8. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular breakable portion includes an annular upper sloping portion extending upward from the smallest diameter portion and an annular lower sloping portion extending downward from the smallest diameter portion, and an angle between the annular upper sloping portion and the annular lower sloping portion is 45° to 75°.

9. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular breakable portion has an annular upper sloping portion extending upward from the smallest diameter portion, and an angle between the annular upper sloping portion and a horizontal line passing through an imaginary annular plane formed by the smallest diameter portion is 15° to 75°.

10. A drug-filled synthetic resin ampule according to claim 1 , wherein a corner portion of the internal ceiling portion has an edge-free curved surface.

11. A drug-filled synthetic resin ampule according to claim 1 , wherein the tip-side sealing portion includes a reinforcing portion which extends upward from a lower portion of the tip-side sealing portion and ends at a lower end portion of the flat plate portion for grasping.

12. A drug-filled synthetic resin ampule according to claim 1 , wherein the annular smallest diameter portion has a cross section having the shape of a short arc.

13. A synthetic resin ampule body for a drug-filled ampule, comprising
a tip-side sealing portion, a hollow portion having a drug containing portion, and an annular breakable portion provided at a lower portion of the tip-side sealing portion;
wherein the annular breakable portion includes an annular smallest diameter portion, and the tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof and an internal ceiling portion exposed to an interior of the hollow portion;
the smallest diameter portion of the annular breakable portion is located near an annular circumferential edge portion of the internal ceiling portion and is located above the annular circumferential edge portion of the internal ceiling portion;
the internal ceiling portion has a flat portion located radially inward of the annular circumferential edge portion and below the annular breakable portion;
the hollow ampule body has a diameter reducing portion that reduces in outer and inner diameter toward the annular breakable portion; and
the annular breakable portion has a thin weak portion located at an upper end portion of said diameter reducing portion and located between the annular smallest diameter portion and the annular circumferential edge portion.

14. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the annular smallest diameter portion is an annular smallest diameter portion formed to have an acute angle.

15. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the ampule is broken at the annular breakable portion as a result of the flat plate portion for grasping of the tip-side sealing portion being grasped and twisted.

16. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the synthetic resin ampule body is formed of a hard or semi-hard synthetic resin material through injection molding.

17. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the tip-side sealing portion includes a reinforcing portion which extends upward from a lower portion of the tip-side sealing portion and ends at a lower end portion of the flat plate portion for grasping.

18. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the annular breakable portion includes an annular upper sloping portion extending upward from the smallest diameter portion and an annular lower sloping portion extending downward from the smallest diameter portion, and an angle between the annular upper sloping portion and the annular lower sloping portion is 45° to 75°.

19. A synthetic resin ampule body for a drug-filled ampule according to claim 13 , wherein the annular smallest diameter portion has a cross section having the shape of a short arc.

20. A drug-filled synthetic resin ampule comprising
a hollow ampule body, a lower-end-side sealing member for sealing a lower end of the hollow ampule body, and a drug filled in the hollow ampule body;
wherein the hollow ampule body includes a tip-side sealing portion, a hollow portion located below the tip-side sealing portion and having a drug containing portion therein, and an annular breakable portion provided at a lower portion of the tip-side sealing portion;
the tip-side sealing portion includes a flat plate portion for grasping formed at an upper portion thereof and an internal ceiling portion exposed to an inter

Assignees

• Terumo Corp

Inventors

• Harada Naomi
• Chiba Akira
• YAMAGAMI Masahide
• Masuda Taeko

Classifications

• A61J1/065 Primary

  Rigid ampoules, e.g. glass ampoules · CPC title

• B65D1/09

  Ampoules · CPC title

• A61J1/1431

  Permanent type, e.g. welded or glued · CPC title

• A61J1/1406

  Septums, pierceable membranes · CPC title