Dual run cassette for the synthesis of 18F-labelled compounds
US-10584078-B2 · Mar 10, 2020 · US
US11529579B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11529579-B2 |
| Application number | US-202016751649-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 24, 2020 |
| Priority date | Sep 25, 2017 |
| Publication date | Dec 20, 2022 |
| Grant date | Dec 20, 2022 |
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A filtration device includes a first channel member, a second channel member, and a filter. The first channel member has a recess recessed inward from an outer wall surface. A groove is formed is the recess and has an opening in a recessed surface of the recess. First and second channels, each defined by a through-hole, are formed in the first channel member and are connected to the groove. A first connection part connects the groove with the first channel. The second channel member has a projection that detachably mates with the recess. The second channel member includes a discharge channel that has an opening in a projecting surface of the projection, the opening being located over the groove. The filter is disposed along the groove, and positioned at the opening of the discharge channel. When the first and second channel members are placed in a operative relationship, a third channel is formed by the projecting surface of the projection and the opening of the groove. The third channel is connected to the first channel via the first connection part. The third channel at which the filter is positioned has a smaller cross-sectional area than the first channel.
Opening claim text (preview).
The invention claimed is: 1. A filtration device comprising: (a) a first channel member including: (i) a recess recessed inward from an outer wall surface; (ii) a groove formed in a recessed surface of the recess, the groove having an opening; (iii) first and second channels defined by respective through-holes connected to the groove; (iv) a first connection part connecting the groove with the first channel; and (v) a second connection part connecting the groove with the second channel; (b) a second channel member removably connected to the first channel member, the second channel member having a projection which includes a projection surface that cooperates with the recess of the first channel member to define a third channel located between the first and second channels of the first channel member, the third channel being connected to the first channel via the first connection part and being connected to the second channel via the second connection part, the third channel having a smaller cross-sectional area than the first channel, the second channel member including a discharge channel located in the projection and having an opening that extends through the projection surface; and (c) a filter positioned at the opening of the discharge channel such that the filter is located along the third channel, wherein: the recessed surface of the recess of the first channel member defines a flat surface; the projection surface of the projection of the second channel member defines a flat surface; and the first channel member and the second channel member are mated with each other by bringing the recessed surface of the recess and the projecting surface of the projection into surface contact with each other. 2. The filtration device according to claim 1 , wherein the recess and the projection are detachably mated with each other without using another intervening component. 3. The filtration device according to claim 2 , wherein: the first channel member has a recessed mating surface on a lateral side of the recess to allow mating between the recess and the projection; the second channel member has a projecting mating surface on a lateral side of the projection to allow mating between the recess and the projection; the recessed mating surface includes a notch recessed inwardly of the first channel member; the projecting mating surface includes a protrusion, the protrusion protruding outwardly of the second channel member to mate with the notch; and the second channel member is detachably attached to the first channel member by mating the protrusion with the notch. 4. The filtration device according to claim 3 , wherein: the recessed mating surface defines a sloped surface which is inclined with respect to the recessed surface of the recess; the projecting mating surface defines a sloped surface which is inclined with respect to the projecting surface of the projection that contacts the recessed surface of the recess; and the first and second channel members are mated with each other by bringing the recessed mating surface and the projecting mating surface into surface contact with each other. 5. The filtration device according to claim 1 , wherein: the filter has a first major surface and a second major surface that face each other; the first major surface is disposed adjacent to the third channel; the second major surface is disposed adjacent to the discharge channel; and the first major surface and the projecting surface are flush with each other. 6. The filtration device according to claim 1 , wherein the second channel has a larger cross-sectional area than the third channel. 7. The filtration device according claim 1 , wherein the filter is attached to the second channel member. 8. The filtration device according to claim 1 , wherein the groove extends linearly. 9. The filtration device according to claim 1 , wherein the first channel member includes a plurality of recesses, and each recess mates with the second channel member to which the filter is attached. 10. The filtration device according claim 1 , wherein: the discharge channel is a first discharge channel; the opening is a first opening; the filter is a first filter; the second channel member includes a second discharge channel having a second opening that extends through the projection surface; a second filter positioned at the second opening of the second discharge channel such that the second filter is located along the third channel. 11. The filtration device according to claim 1 , wherein the first, second and third channels are linearly extending. 12. The filtration device according to claim 1 , wherein the first and second channels are circular in cross section and the third channel has a semicircular cross section.
Constructional details · CPC title
Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration · CPC title
Specific process operations in the feed stream; Feed pretreatment · CPC title
Displacing liquid, e.g. from wet solids or from dispersions of liquids or from solids in liquids, by means of another liquid · CPC title
Flow characteristics of the filter · CPC title
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