Non-fibrous porous film and method for tissue adhesion

Patent metadata

Field	Value
Publication number	US-11529435-B2
Application number	US-202117308547-A
Country	US
Kind code	B2
Filing date	May 5, 2021
Priority date	Dec 29, 2016
Publication date	Dec 20, 2022
Grant date	Dec 20, 2022

Abstract

The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.

First claim

What is claimed is:

1. A non-fibrous porous film, which is manufactured by a method for manufacturing a non-fibrous porous film, wherein the method for manufacturing a non-fibrous porous film comprises:
preparing a polymer mixture solution, wherein the polymer mixture solution comprises:
polycaprolactone (PCL); and
at least one hydrophobic polymer, which is selected from a group consisting of polylactic acid (PLA), poly(lactic-co-glycolic acid (PLGA), poly(glycolic acid) (PGA), polyhydroxybutyrate (PHB), polydioxanone (PDS), poly(propylene fumarate) (PPF), polyanhydrides, polyacetals, poly(ortho esters), polycarbonates, polyurethanes, polyphosphazenes and polyphosphoester, wherein the molecular weight of the at least one hydrophobic polymer is 10K-800K;

adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture, wherein the particle size of the solid particles is 50-250 μm;
drying the solid mixture to form a film; and
washing the film with a washing fluid to remove the solid particles from the film to form a porous film,
wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is 1:0.1 to 1:10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to solid particles is 1:0.01 to 1:250, and

wherein the real density of the non-fibrous porous film is 1.5-5.0×10 −3 g/cm 2 .

2. The non-fibrous porous film as claimed in claim 1 , wherein the porosity of the non-fibrous porous film is 80-99%.

3. The non-fibrous porous film as claimed in claim 1 , wherein the thickness of the non-fibrous porous film is 10-1000 μm.

4. The non-fibrous porous film as claimed in claim 1 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), and the solid particles are sodium chloride particles.

5. The non-fibrous porous film as claimed in claim 4 , wherein the weight ratio of the polycaprolactone to the poly(lactic-co-glycolic acid) is 1:0.1 to 10, and the weight ratio of the polycaprolactone and the poly(lactic-co-glycolic acid) to the sodium chloride particle is 1:0.01 to 250.

6. The non-fibrous porous film as claimed in claim 1 , wherein the polymer mixture solution further comprises at least one hydrophobic drug, wherein the weight ratio of the polycaprolactone, the at least one hydrophobic polymer and the at least one hydrophobic drug to solid particles is 1:0.5 to 10.

7. The non-fibrous porous film as claimed in claim 6 , wherein the weight ratio of the polycaprolactone to the at least one hydrophobic drug is 1:0.05 to 5.

8. The non-fibrous porous film as claimed in claim 6 , wherein the at least one hydrophobic drug comprises citral, nitrogen mustard, cisplatin, paclitaxel or a combination thereof.

9. The non-fibrous porous film as claimed in claim 6 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), the at least one hydrophobic drug is citral, and the solid particles are sodium chloride particles.

10. A non-fibrous porous film, which is composed of a polymer mixture, wherein the polymer mixture comprises:
polycaprolactone; and
at least one hydrophobic polymer, which is selected from a group consisting of polylactic acid (PLA), poly(lactic-co-glycolic acid (PLGA), poly(glycolic acid) (PGA), polyhydroxybutyrate (PHB), polydioxanone (PDS), poly(propylene fumarate) (PPF), polyanhydrides, polyacetals, poly(ortho esters), polycarbonates, polyurethanes, polyphosphazenes and polyphosphoester, wherein the molecular weight of the at least one hydrophobic polymer is 10K-800K,
wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is 1:0.1 to 10, and wherein the porosity of the non-fibrous porous film is 80-99%, and the roughness of the non-fibrous porous film is 10-500 μm,
wherein the real density of the non-fibrous porous film is 1.5-5.0×10 −3 g/cm 2 .

11. The non-fibrous porous film as claimed in claim 10 , wherein the thickness of the non-fibrous porous film is 10-1000 μm.

12. The non-fibrous porous film as claimed in claim 10 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid).

13. The non-fibrous porous film as claimed in claim 12 , wherein the weight ratio of the polycaprolactone to the poly(lactic-co-glycolic acid) is 1:0.1 to 10.

14. The non-fibrous porous film as claimed in claim 10 , wherein the polymer mixture further comprises at least one hydrophobic drug, wherein the weight ratio of the polycaprolactone, the at least one hydrophobic polymer and the at least one hydrophobic drug to solid particles is 1:0.5 to 10.

15. The non-fibrous porous film as claimed in claim 14 , wherein the weight ratio of the polycaprolactone to the at least one hydrophobic drug is 1:0.05 to 5.

16. The non-fibrous porous film as claimed in claim 14 , wherein the at least one hydrophobic drug comprises citral, nitrogen mustard, cisplatin, paclitaxel or a combination thereof.

17. The non-fibrous porous film as claimed in claim 14 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), the at least one hydrophobic drug is citral, and the solid particles are sodium chloride particles.

18. A method for tissue adhesion, comprising:
applying the non-fibrous porous film as claimed in claim 1 to a location in a body which needs tissues to adhere to each other to promote tissue-adhesion.

19. The method for tissue adhesion as claimed in claim 18 , wherein the thickness of the non-fibrous porous film is 10-1000 μm.

20. The method for tissue adhesion as claimed in claim 18 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid).

21. The method for tissue adhesion as claimed in claim 18 , wherein the polymer mixture solution or the polymer mixture further comprises at least one hydrophobic drug, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic drug is 1:0.05 to 5.

22. The method for tissue adhesion as claimed in claim 21 , wherein the at least one hydrophobic drug comprises citral, nitrogen mustard, cisplatin, paclitaxel or a combination thereof.

23. The method for tissue adhesion as claimed in claim 21 , wherein the at least one hydrophobic polymer is poly(lactic-co-glycolic acid), and the at least one hydrophobic drug is citral.

24. A method for tissue adhesion, comprising:
applying the non-fibrous porous film as claimed in claim 10 to a location in a body which needs tissues to adhere to each other to promote tissue-adhesion.

Assignees

• Ind Tech Res Inst

Inventors

• Shen Hsin-Hsin
• Yang Ming-Chia
• Ho Chia-Chi
• Jang Fang-Jie
• Ou Che-Yu
• Liao Chi-Hsiang
• Hsu Brian
• Young Tai-Horng

Classifications

• A61L24/0042

  Materials resorbable by the body · CPC title

• A61L24/0036 Primary

  Porous materials, e.g. foams or sponges · CPC title

• A61L24/043

  Mixtures of macromolecular materials · CPC title

• A61L24/0089

  containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084 · CPC title

• A61L2300/216

  with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups · CPC title