Natural preservatives and antimicrobial agents, including compositions thereof

Patent metadata

Field	Value
Publication number	US-11529384-B2
Application number	US-202017026736-A
Country	US
Kind code	B2
Filing date	Sep 21, 2020
Priority date	Nov 9, 2015
Publication date	Dec 20, 2022
Grant date	Dec 20, 2022

Abstract

Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.

First claim

The invention claimed is:

1. A composition, comprising: a mixture of at least one Albizia extract and at least one Magnolia extract, wherein the at least one Albizia extract is enriched for one or more macrocyclic alkaloids, wherein the at least one Magnolia extract is enriched for one or more lignans, and wherein the at least one Albizia extract and the at least one Magnolia extract are blended in a weight ratio ranging from 1:1 to 1:3.

2. A food, cosmetic, nutraceutical or pharmaceutical that comprises the composition of claim 1 , wherein the composition is a preservative.

3. The composition of claim 2 , wherein the composition is present in the food, cosmetic, nutraceutical or pharmaceutical in a range from about 0.001% to about 10% by weight of the total weight of the food, cosmetic, nutraceutical or pharmaceutical.

4. The composition of claim 3 , wherein the composition is present in the food, cosmetic, nutraceutical or pharmaceutical in a range from about 0.01% to about 5% by weight of the total weight of the food, cosmetic, nutraceutical or pharmaceutical.

5. The composition of claim 1 , wherein the Albizia extract and the Magnolia extract are blended in a weight ratio at 1:1.

6. The composition of claim 1 , wherein the Albizia extract comprises about 0.01% to 99.9% of macrocyclic alkaloids.

7. The composition of claim 1 , wherein Magnolia extract comprises about 0.01% to 99.9% of diphenol lignans.

8. The composition of claim 1 , wherein the Albizia is selected from Albizia schimperiana, Albizia lebbek, Albizia gummifera, Albizzia inopinata, Albizia saman ( Samanea saman=Pithecolobium saman ), Albizia adianthifolia, Albizia adinocephala, Albizia anthelmintics, Albizia antunesiana, Albizia chevalieri, Albizia corniculata, Albizia crassiramea, Albizia duclouxii, Albizia glabra, Albizia julibrissin, Albizia kalkora, Albizia lebbekoides, Albizia myriophylla, Albizia nigricans, Albizia odoratissima, Albizia peterisana, Albizia poilanei, Albizia procera, Albizia tanganyicensis, Albizia vialeana pierre, Albizia zygia, Aphelandra fuscopunctata, Ephedra spp., Verbascum pseudonobile, Incarvillea sinensis, Verbascum phoenicum, Verbascum nigrum, Clerodendrum buchneri, Aphelandra squarrosa or a combination thereof.

9. The composition of claim 1 , wherein the at least one enriched Albizia extract is extracted from Albizia plants with water, ethanol, methanol, alcohol and water-mixed solvents, or by supercritical fluid.

10. The composition of claim 1 , wherein the alkaloids isolated from the at least one Albizia extract comprise, Felipealbizine A, Felipealbizine B, 6′-Hydroxybudmunchiamine C, Pithecolobine, Protomethine, Verbamethine, Verbametrine, Isoverbametrine, Isoverbamethine, Verbamekrine, Isoverbamekrine, Verbascine, Verbacine, Verbasitrine, Verballocine, Isoverbasitrine, Verballoscenine, Isoverbasikrine, N1-(Z)-p-Methoxycinnamoylbuchnerine, Buchnerine, Verbamedine, Verbascenine, Verbascenine, Isoverbamedine, Schweinine, Prelandrine, Incasine B′, Incasine B or a combination thereof.

11. The composition of claim 1 , wherein the at least one enriched Magnolia extract is extracted from Magnolia plants with water, ethanol, methanol, alcohol and water mixed solvents, or by supercritical fluid.

12. The composition of claim 1 , wherein the Magnolia comprises— Magnolia acuminate, Magnolia biondii, Magnolia coco, Magnolia denudate, Magnolia fargesii, Magnolia garrettii, Magnolia grandiflora, Magnolia henryi, Magnolia liliflora, Magnolia kachirachirai, Magnolia kobus, Magnolia obovata, Magnolia praecocissima, Magnolia pterocarpa, Magnolia pyramidata, Magnolia rostrate, Magnolia salicifolia, Magnolia sieboldii, Magnolia soulangeana, Magnolia stellate, Magnolia virginiana , prod. of degradation of birch lignin, Acanthus ebracteatus, Aptosimum spinescens, Aralia bipinnata, Araucaria angustifolia, Araucaria araucana, Artemisia absinthium, Haplophyllum acutifolium, Haplophyllum perforatum, Liriodendron tulipifera, Krameria cystisoides, Perilla frutescens, Lawsonia inermis Myristica fragrans (nutmeg), Parakmeria yunnanensis (preferred genus name Magnolia ), Persea japonica, Piper futokadsura, Piper wightii, Rollinia mucosa, Sassafras randaiense, Scrophularia albida - colchica, Stellera chamaejasme, Syringa velutina, Syzygium cumini, Talauma gloriensis, Virola elongate, Urbanodendron verrucosum, Wikstroemia sikokiana or a combination thereof.

13. The composition of claim 1 , wherein the lignans isolated from the at least one Magnolia extract comprise Biondinin A, 2,3-Bis(4-hydroxy-3-methoxyphenyl)-2-propenal, Denudadione C, Clovanemagnolol, 8-[2-Hydroxy-5-(2-propenyl)phenyl]-6-(2-propenyl)-2H-1-benzopyran-2-one, Denudanolide C, Denudanolide D, Denudanolide B, Denudanolide A, Denudatin A, Denudatin B; (+)-form, 4-Hydroxy-6′-methoxy-3,3′-biligna-7,7′-diene-9,9′-dial, 4′-Methoxymagndialdehyde, 5,5′-Di-2-propenyl-[1,1′-biphenyl]-2,2′-diol, 2,2′-Bichavicol, FEMA 4559, 5,5′-Diallyl-2,2′-dihydroxybiphenyl, Bornylmagnolol, 5,5′-Diallyl-2-(3-methyl-2-butenyloxy)biphenyl-2′-ol, 5,5′-Diallyl-2-(allyloxy)biphenyl-2′-ol, 3′,5-Diallyl-2,4′-dihydroxybiphenyl, 3′,5-Di-2-propenyl-2,4′-biphenyldiol, 5-Allyl-3′-(1-propenyl)biphenyl-2,4′-diol, 3′-(1-Propenyl)-5-(2-propenyl)-2,4′-biphenyldiol, 3′,5-Diallyl-2-hydroxy-4′-methoxybiphenyl, 4′-O-Methylhonokiol, 2-Hydroxy-4′-methoxy-3′,5-di-2-propenylbiphenyl, 4,4′-Diallyl-2,3′-dihydroxydiphenyl ether, 2-[3-Hydroxy-4-(2-propenyl)phenoxy]-5-(2-propenyl)phenol, 2-Hydroxy-3-methoxy-4′,5-di-2-propenyldiphenyl ether, 4′,5-Diallyl-2-hydroxy-3-methoxydiphenyl ether, 2-Methoxy-4-(2-propenyl)-6-[4-(2-propenyl)phenoxy]phenol, Fargesin, Methyl pluviatilol, 3,4-Dimethoxy-3′,4′-methylenedioxy-7,9′:7′,9-diepoxylignan, Kobusin, Desmethoxyaschantin, 0-Methylpiperitol, Spinescin, (+)-Fargesin, Planinin, Methylpluviatilol, Parakmerin A, 6-Allyl-7-(3,4-dimethoxyphenyl)-2,3-dimethoxy-8-methyltricyclo[4.2.0.02,8]oct-3-en-5-one, Magnosalin, Dipiperitylmagnolol, Kachirachirol B, Acuminatin, Licarin D, Eudeshonokiol A, Eudesmagnolol, Eudesmin; (+)-formm, (+)-Epieudesmin, (−)-Epieudesmin, Kachirachirol A, Eupomatenoid 13, Fargesiphenol B, Fargesiphenol C, Fargesone A, Fargesone B, 4,5-Dimethoxy-3′,4′-methylenedioxy-2,7′-dioxo-5,8′-ligna-3,6,8-triene, 4-(1,3-Benzodioxol-5-yl)-2,3,4,5-tetrahydro-7-methoxy-5-methyl-8H-2,5a-methano-1-benzoxepin-8-one, Garrettilignan A, Garrettilignan B, Tetrahydro-4-(3-hydroxy-4,5-dimethoxyphenyl)-1H,3H-furo[3,4-c]furan-1-one, Kachiranol, 7′,9-Dihydroxy-3,3′,4,4′,5-pentamethoxy-7,9′-epoxylignan, Magnone B, 3,3′,4,4′,5,9-Hexamethoxy-7,9′-epoxylignan-7′-one, Magnolenin C, 3′,4,7,9,9′-Pentahydroxy-3,5′-dimethoxy-8,4′-oxyneolignan, 3,3′-Dimethoxy-4,5:4′,5′-bis(methylenedioxy)pyramidatin, 3′-Hydroxy-3,4,4′,5,5′-pentamethoxypyramidatin, Pyramidatin B, 3,3′,4′,5′-Tetramethoxy-4,5-methylenedioxypyramidatin, 3,3′,4,4′,5,5′-Hexamethoxypyramidatin, Pyramidatin C, Pyramidatin, Pyramidatin D, 3-Hydroxy-3′,4,4′,5,5′-pentamethoxypyramidatin, Pyramidatin A, 3-Hydroxy-3′,4,5-trimethoxy-4′,5′-methylenedioxypyramidatin, Pyramidatin F, Pyramidatin G, Pyramidatin H, Pyramidatin E, 5′-Hydroxy-3,3′,4,4′,5-pentamethoxypyramidatin, Magnoshinin, 2′,3,4,4′,5,6-Hexamethoxy-2,7′-cyclolign-7-ene, Acanthoside B, Eleutheroside E1, 3-Hydroxy-3′,4,4′,5,5′-pentamethoxy-7,9′:7′,9-diepoxylignan, (+)-Episyringaresinol, Lirioresinol A, Symplicosigenol, Kobusinol B, Fargesol, 9-O-Acetylfargesol, Magnolone, Biondinin B, Biondinin E, Magnone A, 7,9,9′-Trihydroxy-3,3′,4-trimethoxy-8,4′-oxyneolignan, erythro-form, threo-form, Magnovatin A, Magnovatin B, Oleiferin C, 3,4:3′,4′-Bis(methylendioxy)-7-lignanol, 7-Hydroxy-3,4:3′,4′-bis(methylenedioxy)lignan, Liliflodione, Denud

Assignees

• Unigen Inc

Inventors

• Jiao Ping
• Oh Mi Sun
• Hong Mei Feng
• Jia Qi

Classifications

• A61K36/575 Primary

  Magnolia · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K36/48

  Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title