Bottle pressurization delivery system

Patent metadata

Field	Value
Publication number	US-11525813-B2
Application number	US-201815885555-A
Country	US
Kind code	B2
Filing date	Jan 31, 2018
Priority date	Mar 14, 2013
Publication date	Dec 13, 2022
Grant date	Dec 13, 2022

Abstract

A container assembly for use with a high-pressure liquid chromatography (HPLC) instrument is disclosed, in which the container assembly, when coupled to a source of pressurized gas, provides fluid medium to the HPLC instrument at positive pressure. The container assembly has an external exterior container shell, an internal fluid container for holding fluid medium, an interstitial volume between the external exterior container shell and the internal fluid container, a port for fluidly connecting the volume to a pressurized gas source, and a port for fluidly connecting the internal fluid container to the HPLC instrument. As a pressurized gas in the interstitial volume increases, fluid medium flows out of the port connected to the internal fluid bag and container assembly at a positive pressure. A system incorporating the container assembly, and method of use of the same, are also disclosed.

First claim

What is claimed is:

1. A bulk fluidics module for a high performance liquid chromatography (HPLC) instrument, comprising:
a gas pressurization system;
a reagent consumable region, having a plurality of gas interface ports and a plurality of fluid interface ports;
a pressurized gas channel, configured to connect and allow for passage of gas from the gas pressurization system to the plurality of gas interface ports;
a consumable decompression region, configured to receive pressurized liquids through the plurality of fluid interface ports and to regulate pressure of received pressurized liquids; and
a fluid distribution region, configured to receive liquids from the consumable decompression region and to direct received liquids out of the bulk fluidics module.

2. The module according to claim 1 , further comprising control electronics operatively connected with the gas pressurization system, the consumable decompression region, and the fluid distribution region, and is configured to receive fluid volume information from one or more container assemblies coupled to the reagent consumable region.

3. The module according to claim 2 , further comprising a leak detection region, operatively coupled to the control electronics, arranged between the plurality of fluid interface ports and the consumable decompression region, the leak detection region comprising one or more sensors and configured to trigger a warning indicator, a reduction in gas flow to the plurality of gas interface ports, closing of valves in fluid communication with the plurality of fluid interface ports, or a combination thereof.

4. The module according to claim 3 , wherein the one or more sensors comprise thermal sensors, voltage sensors, electrical current sensors, or a combination thereof.

5. The module according to claim 1 , further comprising a buffer conditioner configured to receive a buffer fluid from the fluid distribution region and to further direct the buffer fluid to a separation module of the HPLC instrument.

6. The module according to claim 1 , further comprising a buffer conditioner configured to receive a reagent fluid from the fluid distribution region and to further direct the reagent fluid to a separation module of the HPLC instrument.

7. The module according to claim 1 , further comprising a diluent conditioner configured to receive a dilution fluid from the fluid distribution region and to further direct the dilution fluid to a dilution module of the HPLC instrument.

8. The module according to claim 1 , further comprising a waste container subassembly configured to receive fluids from a dilution module, a separation module, a detection module, or a combination thereof.

9. The module according to claim 1 , wherein the reagent consumable region configured to mount a plurality of container assemblies in cantilever.

10. The module according to claim 1 , wherein the reagent consumable region is configured to mount a plurality of container assemblies, wherein each container assembly has a first opening configured to couple with one of the plurality of gas interface ports and a second opening configured to couple with one of the plurality of fluid interface ports.

11. The module according to claim 1 , wherein within the consumable decompression region, pressurized fluid from two of the plurality of gas interface ports are combined into a single fluid stream, wherein the pressurized fluid from the two of the plurality of gas interface ports are the same type of fluid.

12. The module according to claim 1 , wherein within the fluid distribution region, two liquids from the consumable decompression region are combined into a single fluid stream, wherein two liquids are different types of liquids.

Assignees

• Bio Rad Laboratories Inc

Inventors

• Wrench Nathan
• Mainwaring-Burton William
• Butcher Chris
• Harrison Nick

Classifications

• G01N30/16

  Injection (G01N30/24 takes precedence) · CPC title

• Y10T137/9029

  With coupling · CPC title

• B67D7/0255

  squeezing collapsible or flexible storage containers (for dispensing beverages on draught B67D1/0462) · CPC title

• G01N30/88 Primary

  Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 · CPC title

• G01N2030/8881

  Modular construction, specially adapted therefor · CPC title