Particle detection device and particle detection method

Patent metadata

Field	Value
Publication number	US-11525765-B2
Application number	US-201816484964-A
Country	US
Kind code	B2
Filing date	Feb 13, 2018
Priority date	Feb 10, 2017
Publication date	Dec 13, 2022
Grant date	Dec 13, 2022

Abstract

The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.

First claim

The invention claimed is:

1. A particle detection device comprising:
a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and
two or more particle recovery channels that are connected to and branched from the particle separation channel,
wherein the particle separation channel comprises a particle diffusion channel or an expanding channel which has a structure where the width or height of the channel or both of them expand from the fluidly upstream side toward the fluidly downstream side,
wherein each of the particle recovery channels comprises a particle detection unit that includes an aperture and an electric detector,
wherein the cross section areas, volumes, or the cross section areas and the volumes of the apertures of the particle detection units in each particle recovery channel are different from one another.

2. The particle detection device according to claim 1 , wherein a particle size range that can be detected by the aperture of the particle detection unit in each particle recovery channel is different from one another.

3. The particle detection device according to claim 1 , wherein a part of the particle size range that can be detected by the aperture of the particle detection unit in each particle recovery channel overlaps one another.

4. The particle detection device according to claim 1 , wherein at least one parameter among the number, the shape of a branch part, width, height, and length of the particle recovery channels is adjusted to form a channel structure where particles of a certain size or more are not mixed therein.

5. The particle detection device according to claim 1 , wherein the particle separation channel includes: two or more branch channels that each comprises a fluid introduction port on one end; and a channel that is formed by joining the branch channels, wherein fluid that includes particles to be separated is introduced from the fluid introduction port of at least one of the branch channels.

6. A method for detecting particles included in fluid using the particle detection device according to claim 1 , comprising:
separating the particles according to particle sizes in a perpendicular direction to the flow of the fluid;
dividing the separated particles into two or more channels; and
detecting the particles by an electric detector including electrodes that are disposed on both sides of an aperture equipped in the channel.

7. The method according to claim 6 , wherein a particle size range that can be detected by the electric detector differs depending on a channel on which the electric detector is installed.

8. The method according to claim 6 , wherein a part of the particle size range that can be detected by electric detector overlaps one another depending on a channel on which the electric detector is installed.

9. The method according to claim 6 , wherein at least one parameter among the number, the shape of a branch part, width, height, and length of the channels is adjusted to form a channel structure where particles of a certain size or more are not mixed therein.

10. The method according to claim 6 , wherein the particle separation channel includes: two or more branch channels that each comprises a fluid introduction port on one end; and a channel that is formed by joining the branch channels, wherein fluid that includes particles to be separated is introduced from the fluid introduction port of at least one of the branch channels.

11. The method according to claim 10 , wherein the flow rate of fluid including particles to be separated is smaller than the flow rate of other fluid.

12. The method according to claim 10 , wherein, in a channel formed by joining fluid including particles to be separated and fluid that was introduced to another branch channel, the joined fluid makes a laminar flow.

13. The method according to claim 10 , wherein the particles are separated under a condition where occurrence of a swirling flow and particle diffusion is suppressed on the wall surface side along which the particles flow smoothly.

14. The method according to claim 6 , wherein, in the particle separation channel, particles are separated under a condition where the wall of the channel does not easily expand outward.

15. The particle detection device according to claim 1 , further comprising:
a fluid discharge port provided downstream of the particle detection unit,
wherein an electrode of the electric detector is provided at the fluid discharge port.

16. The particle detection device according to claim 1 , wherein, in the particle separation channel, the wall of the channel is made of material that does not easily expand outward.

17. The particle separation device according to claim 16 , wherein the material has 40 durometer hardness or more.

18. The particle detection device according to claim 1 , wherein
the particle separation channel comprises:
two or more branch channels that each includes a fluid introduction port on one end side and joins the other branch channels on the other end side;
a pinched channel that is formed by joining the two or more branch channels; and
an expanding channel that is connected to the other end of the pinched channel and has an expanded channel width,

wherein the two or more particle recovery channels are connected to the expanding channel, and, when fluid that includes particles to be separated is introduced from the fluid introduction port of one of the branch channels and fluid that does not include the particles to be separated is introduced from the fluid introduction port of another one of the branch channels, particles flow smoothly along the wall surface of the pinched channel, and the channel width of the expanding channel does not expand toward the wall surface side along which the particles flow smoothly, yet, expands toward the wall surface side along which the particles do not flow smoothly.

19. The particle separation device according to claim 18 , wherein the channel width gradually expands toward the wall surface side along which the particles do not flow smoothly.

20. The particle separation device according to claim 18 , wherein the channel width of the expanding channel gradually expands toward the wall surface side along which the particles do not flow smoothly, and an angle between the wall surface of the pinched channel and the wall surface of the expanding channel forms 90° or more.

21. The particle separation device according to claim 20 , wherein the channel width of the expanding channel gradually expands toward the wall surface side along which the particles do not flow smoothly, and the expanding angle between the wall surface of the pinched channel and the wall surface of the expanding channel forms 135° or more.

22. The particle detection device according to claim 1 ,
wherein the particle separation channel comprises:
two or more branch channels that each includes a fluid introduction port on one end side and joins the other branch channels on the other end side;
a pinched channel that is formed by joining the two or more branch channels; and
an expanding channel that is connected to the other end of the pinched channel and has an expanded channel width,

wherein the two or more particle recovery channels are connected to the expanding channel, and, when fluid that includes particles to be separated is introduced from the fluid introduction port of one of the branch channels

Assignees

• Tosoh Corp
• Univ Chiba Nat Univ Corp

Inventors

• Iijima Kazuki
• Toyoshima Toshinobu
• Furukawa Kotohiro
• Katayama Koji
• Jin Naotaka
• Seki Minoru

Classifications

• B01L3/502761 Primary

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• G01N2015/1006

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• G01N2015/0288

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• B01L2300/0645

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