Multi-sensor component for bioprocess control

Patent metadata

Field	Value
Publication number	US-11525710-B2
Application number	US-202016915442-A
Country	US
Kind code	B2
Filing date	Jun 29, 2020
Priority date	Jun 27, 2019
Publication date	Dec 13, 2022
Grant date	Dec 13, 2022

Abstract

A multi-sensor component for the installation of at least two sensors at an individual port of a container for culturing biological material is provided. The multi-sensor component has a housing that can be introduced by a front housing segment into an uptake opening extending through the port of the container so that the front housing segment is facing the inside of the container. The multi-sensor component has a first sensor unit or a mount for a first sensor unit arranged on the front housing segment and has a second sensor unit or a mount for a second sensor unit arranged on the front housing segment.

First claim

What is claimed is:

1. A multi-sensor component for the installation sensors at an individual port of a container for culturing biological material, the component comprising:
a housing having a front housing segment, the front housing segment being capable of being introduced into an uptake opening of the individual port so that the front housing segment faces the container;
a first mount for a first sensor unit arranged in the front housing segment; and
a second mount for a second sensor unit arranged in the front housing segment, wherein the first and second sensor units are configured to simultaneously determine different parameters from one another and/or different analytes from one another.

2. The component of claim 1 , further comprising the first sensor unit secured to the first mount and/or the second sensor unit secured to the second mount.

3. The component of claim 2 , wherein the first and/or second sensor unit is a biosensor unit.

4. The component of claim 3 , wherein the biosensor unit is a flat chip.

5. The component of claim 2 , wherein one of the first and second sensor units is a luminophore unit for luminescence-based parameter measurement.

6. The component of claim 5 , wherein the luminophore unit comprises a basic body with a cavity accommodating a luminophore substance.

7. The component of claim 6 , wherein the basic body comprises a front region and a back region, the front region facing the container and the back region facing an outside of the container, wherein the front region comprises the cavity, and wherein the back region comprises a light source and/or a photoelement.

8. The component of claim 6 , wherein the luminophore substance comprises a material selected from a group consisting of: graphene quantum dots, (GQDs), heterocyclic GQDs (e.g. N-GQDs), an organometallic compound, ground glass powder, and xerogel.

9. The component of claim 7 , wherein the front region comprises glass or glass ceramics.

10. The component of claim 9 , wherein the back region comprises optical fibers forming a light guide.

11. The component of claim 10 , wherein the front region has a disc shape and the back region has a rod shape, and wherein the basic body further comprises a laser weld securing the front and back regions to one another.

12. A biological material culturing container, comprising:
a container with an inside and an outside;
a port that connects the inside to the outside;
a sensor uptake having an inner uptake opening, wherein the sensor uptake has a front sensor uptake section in the port so that the inner uptake opening extends through the port;
a multi-sensor component having a housing with a front housing segment, the front housing segment being introduced into the inner uptake opening so that the front housing segment faces the container;
a first mount for a first sensor unit arranged in the front housing segment; and
a second mount for a second sensor unit arranged in the front housing segment,
wherein the first sensor unit is secured to the first mount and/or the second sensor unit is secured to the second mount, and
wherein the first sensor unit is a biosensor unit and the second sensor unit is a luminophore unit for luminescence-based parameter measurement.

13. The container of claim 12 , wherein the luminophore unit comprises a basic body with a cavity accommodating a luminophore substance, a front region, and a back region, the front region facing the container and the back region facing an outside of the container, wherein the front region comprises the cavity, and wherein the back region comprises a light source and/or a photoelement.

14. The container of claim 13 , wherein the luminophore substance comprises a material selected from a group consisting of: graphene quantum dots, (GQDs), heterocyclic GQDs (e.g. N-GQDs), an organometallic compound, ground glass powder, and xerogel.

15. The container of claim 13 , wherein the front region comprises glass or glass ceramics and the back region comprises optical fibers forming a light guide.

16. The container of claim 15 , wherein the front region has a disc shape and the back region has a rod shape, and wherein the basic body further comprises a laser weld securing the front and back regions to one another.

17. A method for producing a multi-sensor component, comprising:
providing a luminophore sensor unit;
providing a housing comprising polyether ether ketone (PEEK) that can be introduced at least by a front housing segment into an uptake opening extending through a port of a container so that the front housing segment is facing the inside of the container;
providing the housing with a recess for the luminophore sensor unit bringing about a relative expansion of the housing with respect to the luminophore sensor unit by heating the housing;
inserting the luminophore sensor unit into the recess of the housing while expanded;
bringing about a relative contraction of the housing with respect to the luminophore sensor unit by cooling the housing so that the housing solidly accommodates the luminophore sensor unit in the recess.

Assignees

• Schott Ag

Inventors

• Ott Christian
• Kolberg Christoph

Classifications

• G01D5/268

  using optical fibres (G01D5/28 - G01D5/38 take precedence) · CPC title

• C12M23/38

  Caps; Covers; Plugs; Pouring means · CPC title

• C12M23/06

  Tubular (C12M23/08, C12M23/16 take precedence) · CPC title

• C12M23/44

  Multiple separable units; Modules · CPC title

• C12M41/00

  Means for regulation, monitoring, measurement or control, e.g. flow regulation (controlling or regulating chemical, physical or physicochemical processes B01J19/0006; heating or cooling apparatus for laboratory use B01L7/00; electro optical investigation of individual particles, flow cytometers G01N15/14; automatic analysis G01N35/00; controlling or regulating in general G06N) · CPC title