Discrete volume dispensing system flow rate and analyte sensor

Patent metadata

Field	Value
Publication number	US-11524290-B2
Application number	US-201816649211-A
Country	US
Kind code	B2
Filing date	Sep 21, 2018
Priority date	Sep 21, 2017
Publication date	Dec 13, 2022
Grant date	Dec 13, 2022

Abstract

A device for determining the amount or concentration of an analyte in a fluid sample and a flow rate of the fluid sample in a channel is provided. The device includes a chamber including a channel and an opening the channel in fluid communication with the opening. The device further includes a wicking component positioned adjacent to the opening configured to receive an amount of fluid from the channel. The device may further include an analyte sensor positioned on the wicking component, the analyte sensor configured to detect an analyte in fluid in contact with the analyte sensor, wherein the wicking component is configured to contact the amount of fluid with the analyte sensor. Alternatively the device may include at least one pair of electrodes configured to determine a flow rate of the fluid in the channel.

First claim

What is claimed is:

1. A device, comprising:
a chamber including a channel and an opening, wherein the channel is in fluidic communication with the opening;
a wicking component positioned proximate to the opening, wherein the wicking component is configured to receive an amount of biofluid from the channel; and
a sensor configured to measure a characteristic of an analyte in the biofluid, wherein the sensor is in fluidic communication with the wicking component, and wherein the wicking component is configured to contact the sensor with the amount of biofluid, and
wherein the wicking component is positioned no less than 1 μm from the opening.

2. The device of claim 1 further comprising a pump, wherein the pump is in fluidic communication with the wicking component, and wherein the pump is configured to promote contact between the amount of biofluid and the sensor.

3. The device of claim 2 , wherein the pump is configured to absorb the amount of biofluid after the amount of biofluid contacts the sensor.

4. The device of claim μ wherein the wicking component is positioned no more than 1 cm from the opening, and has a diameter of no more than 1 cm and no less than 1 μm.

5. The device of claim 1 , wherein the amount of biofluid is independent of a flow rate of fluid in the channel.

6. The device of claim 1 , wherein the amount of biofluid fluid forms a droplet, wherein the droplet has a convex meniscus when received by the wicking component.

7. The device of claim 1 , wherein the channel is coated with a hydrophobic material.

8. The device of claim 1 , wherein the chamber includes a surface treatment around the opening.

9. The device of claim 8 , wherein the surface treatment includes one of the following: an angled rim; a raised shelf; a hydrophobic coating; and an antimicrobial coating.

Assignees

• Univ Cincinnati
• Eccrine Systems Inc

Inventors

• Francis Jessica
• Larson Mikel
• Hoffman Michelle D
• Gomez Eliot
• Heikenfeld Jason Charles
• Stamper Isaac

Classifications

• B01L2300/069

  Absorbents; Gels to retain a fluid · CPC title

• A61B5/14521

  using means for promoting sweat production, e.g. heating the skin (measuring sweat secretion A61B5/4266) · CPC title

• B01L3/502715 Primary

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01L2400/022

  droplet contacts the surface of the receptacle · CPC title

• B01L2300/0636

  Integrated biosensor, microarrays · CPC title