Method for detecting a radical compound derived from a lipid and a compound derived from the radical compound
US-2018328951-A1 · Nov 15, 2018 · US
Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases
US11519893B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11519893-B2 |
| Application number | US-201816628446-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 5, 2018 |
| Priority date | Jul 6, 2017 |
| Publication date | Dec 6, 2022 |
| Grant date | Dec 6, 2022 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
First claim
Opening claim text (preview).
The invention claimed is: 1. An assay kit for detecting lipid peroxidation inhibitory activity of a test compound, comprising: a compound represented by formula (I): a liposome, and at least one compound selected from the group consisting of 2,2′-azobis(2-aminopropane) dihydrochloride and a divalent iron ion source material in a buffer. 2. The assay kit according to claim 1 , wherein the divalent iron ion source material is iron(II) sulfate. 3. The assay kit according to claim 1 , comprising a package insert showing an activity value of a compound having lipid peroxidation inhibitory activity. 4. An assay kit comprising any two or more of the assay kits according to claim 1 .
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Direct analysis of the library members per se by physical methods, e.g. spectroscopy · CPC title
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics · CPC title
Drugs for disorders of the nervous system · CPC title
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title
Antineoplastic agents · CPC title
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- What does patent US11519893B2 cover?
- The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-r…
- Who is the assignee on this patent?
- Yamada Ken Ichi, Fuso Pharmaceutical Ind
- What technology area does this patent fall under?
- Primary CPC classification G01N33/92. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Dec 06 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).