Lactobacillus paracasei strain
US-12152232-B2 · Nov 26, 2024 · US
Engineered microorganisms for the production of intermediates and final products
US11518975B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11518975-B2 |
| Application number | US-201916399597-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 30, 2019 |
| Priority date | Apr 30, 2018 |
| Publication date | Dec 6, 2022 |
| Grant date | Dec 6, 2022 |
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- Title
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Abstract
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The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
First claim
Opening claim text (preview).
What is claimed is: 1. A non-naturally occurring Pseudomonas sp. comprising an endogenous genetic deletion that eliminates the expression of a pyruvate kinase encoded by pykF as well as genetic deletions of gcd and hexR genes, wherein the microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate and muconic acid; and wherein the muconic acid production is greater than that in the naturally occurring Pseudomonas sp. 2. The microorganism of claim 1 , wherein the microorganism is selected from the group consisting of P. putida, P. fluorescens , and P. stutzeri. 3. The microorganism of claim 2 , wherein the microorganism is P. putida KT2440. 4. The microorganism of claim 1 , wherein the microorganism catabolizes at least one of a lignin depolymerization product, a cellulose depolymerization product, and a hemicellulose depolymerization product. 5. The microorganism of claim 4 , wherein the lignin depolymerization product comprises an aromatic compound. 6. The microorganism of claim 4 , wherein the cellulose depolymerization product comprises glucose.
Assignees
Inventors
Classifications
Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases · CPC title
acting on CH-OH groups as donors (1.1) · CPC title
- C12N1/20Primary
Bacteria; Culture media therefor · CPC title
- C12N9/1085Primary
transferring alkyl or aryl groups other than methyl groups (2.5) · CPC title
Lyases (4.) · CPC title
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Frequently asked questions
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- What does patent US11518975B2 cover?
- The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.
- Who is the assignee on this patent?
- Alliance Sustainable Energy, Ut Battelle Llc, Triad Nat Security Llc
- What technology area does this patent fall under?
- Primary CPC classification C12N1/20. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 06 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).