Obstructive sleep apnea treatment devices, systems and methods

Patent metadata

Field	Value
Publication number	US-11517746-B2
Application number	US-202016850926-A
Country	US
Kind code	B2
Filing date	Apr 16, 2020
Priority date	Oct 13, 2006
Publication date	Dec 6, 2022
Grant date	Dec 6, 2022

Abstract

A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea. The stimulation system includes an implantable receiver coil configured to be implanted under a mandible of the patient; a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient; an external pulse generator configured to generate the stimulation signal; and an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient.

First claim

What is claimed is:

1. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:
an implantable receiver coil configured to be implanted under a mandible of the patient;
a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;
an external pulse generator configured to generate the stimulation signal; and
an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient,
wherein the implantable receiver coil and the external transmitter coil each comprise air core wire coils.

2. The stimulation system of claim 1 , further comprising:
a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,
wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters.

3. The stimulation system of claim 1 , wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, a matched numbers of wire turns, or matched wire gauges.

4. The stimulation system of claim 1 , wherein the implantable receiver coil and the external transmitter coil are disposed in a co-axial and parallel arrangement.

5. The stimulation system of claim 1 , wherein the stimulation signal has an operating carrier frequency of 13.56 MHz.

6. The stimulation system of claim 1 , wherein the stimulation signal has an operating carrier frequency of 1.8 MHz.

7. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:
an implantable receiver coil configured to be implanted under a mandible of the patient;
a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;
an external pulse generator configured to generate the stimulation signal; and
an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil configured to be adhesively attached to the patient adjacent the implantable receiver coil under the mandible of the patient,
wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, matched numbers of wire turns, or matched wire gauges.

8. The stimulation system of claim 7 , further comprising:
a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,
wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters.

9. The stimulation system of claim 8 , wherein the sensor is a position sensor and the external pulse generator is configured to adjust the stimulation signal based on a body position of the patient.

10. The stimulation system of claim 9 , wherein the external pulse generator is configured to automatically shut off stimulation when patient sits up or stands up.

11. The stimulation system of claim 7 , wherein the implantable receiver coil and the external transmitter coil are disposed in a co-axial and parallel arrangement.

12. The stimulation system of claim 7 , wherein the stimulation signal has an operating carrier frequency of at least one of 1.8 MHz or 13.56 MHz.

13. A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:
an implantable receiver coil configured to be implanted in a subcutaneous pocket under a mandible of the patient;
a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient;
an external pulse generator configured to generate the stimulation signal;
an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient; and
a sensor in communication with the external pulse generator and configured to measure one or more parameters associated with respiration of the patient,
wherein the external pulse generator is configured to generate the stimulation signal based on the one or more parameters, and
wherein the sensor is a position sensor and the external pulse generator is configured to adjust the stimulation signal based on a body position of the patient.

14. The stimulation system of claim 13 , wherein the implantable receiver coil and the external transmitter coil have at least one of matched wind diameters, a matched numbers of wire turns, or matched wire gauges.

15. The stimulation system of claim 13 , wherein the sensor comprises at least one of:
an impedance sensor;
an electromyographical measurement sensor;
a microphone configured to be arranged proximate the patient's face;
a combination of a flow sensor and a pressure sensor collectively configured to measure flow; or
a temperature sensor configured to detect a difference between cool inspired air versus warm expired air.

16. The stimulation system of claim 13 , wherein the nerve electrode includes a plurality of electrode contacts that are longitudinally arranged along the hypoglossal nerve.

17. The stimulation system of claim 13 , wherein the stimulation signal has an operating carrier frequency of at least one of 1.8 MHz or 13.56 MHz.

Assignees

• Livanova Usa Inc

Inventors

• Bolea Stephen L
• Hoegh Thomas B
• Persson Bruce J
• Atkinson Robert E
• Mazar Scott T

Classifications

• A61N1/3601

  of respiratory organs · CPC title

• A61N1/37229

  Shape or location of the implanted or external antenna · CPC title

• A61B5/7239

  using differentiation including higher order derivatives · CPC title

• A61B5/4818

  Sleep apnoea · CPC title

• A61N1/0558

  Anchoring or fixation means therefor · CPC title