Scaffold

Patent metadata

Field	Value
Publication number	US-11517646-B2
Application number	US-201916688676-A
Country	US
Kind code	B2
Filing date	Nov 19, 2019
Priority date	Oct 4, 2013
Publication date	Dec 6, 2022
Grant date	Dec 6, 2022

Abstract

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

First claim

We claim:

1. A method of producing a scaffold for tissue repair, the method consisting of the steps of:
forming a layered material by laying a single woven material layer onto two or more porous biodegradable polymer fibre layers such that there is a biodegradable adhesive component between each layer, and the two or more porous biodegradable polymer fibre layers are only bonded together via an adhesive component comprising electrospun fibres that are substantially arranged in a grid pattern; and
heating the layered material to a temperature (Tm) above the melting temperature of the adhesive component but below the melting temperature of the material layer and the two or more porous polymer fibre layers, and then cooling the layered material to a temperature below the melting temperature of the adhesive component, thereby bonding the layered material together to form a biodegradable scaffold.

2. The method of claim 1 , wherein pressure is applied to the layered material in order to press the layers together during the heating and cooling.

3. The method of claim 1 , wherein the layered material is heated to a temperature of between about 60° C. and about 100° C.

4. The method of claim 1 , wherein the layered material is heated for at least about 30 seconds prior to cooling.

5. The method of claim 1 , wherein the scaffold is impregnated, seeded or coated with an agent and/or cells.

6. The method of claim 1 , wherein the material layer consists of a woven component that is provided by weaving a fibre, yarn, thread or monofilament into a weave, or a plain weave.

7. The method of claim 6 , wherein the fibre, yarn, thread or monofilament of the woven component is formed by spinning; and optionally by electrospinning.

8. The method of claim 1 , wherein the polymer fibre layer is formed by spinning; and optionally by electrospinning.

9. The method of claim 8 , wherein the electrospinning is onto a grid.

10. The method of claim 7 , wherein agent is incorporated in the fibre, yarn, thread or monofilament of the woven component during the spinning process.

11. The method of claim 8 , wherein an agent is incorporated in the non-woven polymer component and/or adhesive component during the spinning process.

12. The method of claim 1 , wherein the material layer, and/or the polymer fibre layer are formed from PDO.

13. The method of claim 1 , wherein the adhesive component is formed from PCL.

14. The method of claim 1 , wherein the adhesive component between the material layer and the two or more polymer fibre layers is non-porous.

Assignees

• Univ Oxford Innovation Ltd

Inventors

• Hakimi Osnat
• Mouthuy Pierre-Alexis
• Baboldashti Nasim Zargar
• Carr Andrew

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61F13/02

  Adhesive bandages or dressings · CPC title

• A61L27/18 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L2300/64

  Animal cells · CPC title