Methods of microbial treatment of poultry

Patent metadata

Field	Value
Publication number	US-11517595-B2
Application number	US-201816226344-A
Country	US
Kind code	B2
Filing date	Dec 19, 2018
Priority date	Sep 16, 2015
Publication date	Dec 6, 2022
Grant date	Dec 6, 2022

Abstract

Disclosed are methods of administering one or more Bacillus strains to poultry. The Bacillus strains improve bacterial homeostasis in the gastrointestinal tract by inhibiting bacterial pathogens such as E. coli and Clostridium . Administering the Bacillus strains also improves performance such as weight gain and feed conversion. Useful combinations of Bacillus strains and methods of using one or more Bacillus strains are also provided.

First claim

We claim:

1. A microbial composition comprising
(a) at least one isolated Bacillus strain chosen from at least one of strains Bacillus subtilis 1104, deposited as NRRL B-67258; Bacillus subtilis 1781, deposited as NRRL B-67259; Bacillus subtilis 747, deposited as NRRL B-67257; Bacillus subtilis 1541, deposited as NRRL B-67260; and Bacillus subtilis 2018, deposited as NRRL B-67261; present in a concentration of about 10 5 CFU/gram to about 10 12 CFU/gram; and
(b) a carrier;
wherein the composition inhibits a pathogen chosen from at least one of E. coli and Clostridium when administered to an animal,
wherein the composition is a freeze-dried composition, a spray-dried composition, or a fluidized bed dried composition.

2. The microbial composition of claim 1 , wherein the carrier is selected from a group consisting of: whey, maltodextrin, sucrose, dextrose, limestone, rice hulls, and sodium silica aluminate.

3. The microbial composition of claim 2 , wherein the carrier is in the physical form of a powdered solid.

4. An animal feed comprising the microbial composition of claim 1 , wherein the microbial composition has concentration of the at least one isolated Bacillus strain in the composition of about 1×10 8 CFU/g.

5. A direct fed microbial composition comprising
(a) at least one isolated Bacillus strain chosen from at least one of strains Bacillus subtilis 1104, deposited as NRRL B-67258; Bacillus subtilis 1781, deposited as NRRL B-67259; Bacillus subtilis 747, deposited as NRRL B-67257; Bacillus subtilis 1541, deposited as NRRL B-67260; and Bacillus subtilis 2018, deposited as NRRL B-67261 present in a concentration of about 10 5 CFU/gram to about 10 12 CFU/gram; and
(b) a carrier;
wherein the composition inhibits a pathogen chosen from at least one of E. coli and Clostridium in an animal, and
wherein the composition is a freeze-dried composition, a spray-dried composition, or a fluidized bed dried composition.

6. The direct fed microbial composition of claim 5 , wherein the composition comprises a plurality of isolated Bacillus strains chosen from the strains Bacillus subtilis 1104, deposited as NRRL B-67258; Bacillus subtilis 1781, deposited as NRRL B-67259; Bacillus subtilis 747, deposited as NRRL B-67257; Bacillus subtilis 1541, deposited as NRRL B-67260; and Bacillus subtilis 2018, deposited as NRRL B-67261.

7. The direct fed microbial composition of claim 5 , wherein the carrier is selected from a group consisting of: whey, maltodextrin, sucrose, dextrose, limestone, rice hulls, and sodium silica aluminate.

8. A direct fed microbial composition comprising
(a) at least one isolated Bacillus strain is chosen from at least one of strains Bacillus subtilis 1104, deposited as NRRL B-67258; Bacillus subtilis 1781, deposited as NRRL B-67259; Bacillus subtilis 747, deposited as NRRL B-67257; Bacillus subtilis 1541, deposited as NRRL B-67260; Bacillus subtilis 1999, deposited as NRRL B-67318; and Bacillus subtilis 2018, deposited as NRRL B-67261 present in a concentration of about 10 5 CFU/gram to about 10 12 CFU/gram; and
(b) a carrier;
wherein the at least one isolated Bacillus strain inhibits a pathogen chosen from at least one of E. coli and Clostridium in an animal, and
wherein the composition is a freeze-dried composition, a spray-dried composition, or a fluidized bed dried composition.

9. The direct fed microbial composition of claim 8 , wherein the composition comprises a plurality of isolated Bacillus strains chosen from the strains Bacillus subtilis 1104, deposited as NRRL B-67258; Bacillus subtilis 1781, deposited as NRRL B-67259; Bacillus subtilis 747, deposited as NRRL B-67257; Bacillus subtilis 1541, deposited as NRRL B-67260; Bacillus subtilis 1999, deposited as NRRL B-67318; and Bacillus subtilis 2018, deposited as NRRL B-67261.

10. The direct fed microbial composition of claim 8 , wherein the carrier is selected from a group consisting of: whey, maltodextrin, sucrose, dextrose, limestone, rice hulls, and sodium silica aluminate.

Assignees

• Church & Dwight Co Inc

Inventors

• Rehberger Thomas
• Hutchison Evan
• Smith Alexandra
• Rehberger Joshua

Classifications

• A23K50/70

  for birds · CPC title

• A61K38/164

  from bacteria · CPC title

• A23K50/75 Primary

  for poultry · CPC title

• A61K2035/11

  Medicinal preparations comprising living procariotic cells · CPC title

• A61K35/742 Primary

  Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes · CPC title