Compounds and methods for treating nematode infections

Patent metadata

Field	Value
Publication number	US-11517568-B2
Application number	US-202017018158-A
Country	US
Kind code	B2
Filing date	Sep 11, 2020
Priority date	Sep 12, 2018
Publication date	Dec 6, 2022
Grant date	Dec 6, 2022

Abstract

The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (I) and/or (II) as defined herein for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection:

First claim

The invention claimed is:

1. A method of treating or preventing a nematode infection comprising administering an effective amount of a compound of Formula (I) and/or a pharmaceutically acceptable salt and/or solvate thereof, to a subject in need thereof, wherein the compound of Formula (I) is selected from

2. The method of claim 1 , wherein the compound of Formula (I) is selected from

or a pharmaceutically acceptable salt and/or solvate thereof.

3. The method of claim 1 , wherein the compound of Formula (I) is

or a pharmaceutically acceptable salt and/or solvate thereof.

4. The method of claim 1 , wherein the infection is an infection of a nematode of a species selected from Cooperia oncophora, Haemonchus contortus , and Caenorhabditis elegans.

5. The method claim 1 , wherein the subject is selected from a mammal, a bird, a plant, a seed, and soil.

6. The method of claim 1 , wherein the subject is selected from a plant, a seed and soil and the compound is administered pre-planting, post-planting, as a feed additive, a drench, an external application, a pill and/or by injection.

7. A method of treating or preventing a disease, disorder or condition arising from a nematode infection comprising administering an effective amount a compound of Formula (I) and/or a pharmaceutically acceptable salt and/or solvate thereof to a subject in need thereof wherein the compound of Formula (I) is selected from

8. The method of claim 7 , wherein the compound of Formula (I) is selected from

or a pharmaceutically acceptable salt and/or solvate thereof.

9. The method of claim 7 , wherein the compound of Formula (I) is

or a pharmaceutically acceptable salt and/or solvate thereof.

10. The method of claim 7 , wherein the infection is an infection of a nematode of a species selected from Cooperia oncophora, Haemonchus contortus , and Caenorhabditis elegans.

11. The method claim 7 , wherein the subject is selected from a mammal, a bird, a plant, a seed, and soil.

12. The method of claim 7 , wherein the subject is selected from a plant, a seed and soil and the compound is administered pre-planting, post-planting, as a feed additive, a drench, an external application, a pill and/or by injection.

13. A method of treating or preventing a nematode infection comprising administering an effective amount of a composition comprising a compound of Formula I as defined in claim 1 , or a pharmaceutically acceptable salt and/or solvate thereof, to a subject in need thereof.

14. The method of claim 13 , wherein the subject is selected from a plant, a seed and soil and the composition is administered pre-planting, post-planting, as a feed additive, a drench, an external application, a pill and/or by injection.

15. The method of claim 1 , wherein the subject is a human.

16. The method of claim 7 , wherein the subject is a human.

17. A method of treating or preventing a disease, disorder or condition arising from a nematode infection comprising administering an effective amount a composition comprising compound of Formula (I) as defined in claim 7 , or a pharmaceutically acceptable salt and/or solvate thereof, to a subject in need thereof.

18. The method of claim 17 , wherein the subject is selected from a plant, a seed and soil and the composition is administered pre-planting, post-planting, as a feed additive, a drench, an external application, a pill and/or by injection.

Assignees

• Governing Council Univ Toronto

Inventors

• Roy Peter
• Harrington Sean
• Pyche Jacob
• Burns Andrew
• Ross Rachel
• Lautens Mark

Classifications

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title

• A61K31/495 Primary

  having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53}) · CPC title

• A61K9/20

  Pills, tablets, {discs, rods (A61K9/0004, A61K9/0007, A61K9/0056, A61K9/0065 take precedence; for reconstitution of a drink A61K9/0095)} · CPC title

• A61P31/00 Primary

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A23K20/116

  Heterocyclic compounds · CPC title