Nickel-cobalt alloy material devices and components

Patent metadata

Field	Value
Publication number	US-11511213-B2
Application number	US-201615752121-A
Country	US
Kind code	B2
Filing date	Aug 12, 2016
Priority date	Aug 13, 2015
Publication date	Nov 29, 2022
Grant date	Nov 29, 2022

Abstract

Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

First claim

What is claimed is:

1. A device for separating a sample by chromatography, the device comprising:
a body for containing a mobile phase, the body defined by a wall having a wetted surface exposed to the mobile phase including the sample during chromatographic separation, the wetted surface of the wall including an alloy material comprising the following constituents:
nickel; and
cobalt and/or chromium; and

limited in an amount of titanium to 1 wt %.

2. The device of claim 1 , wherein the alloy material is limited in an amount of titanium to 0.1 wt %.

3. The device of claim 1 , wherein the alloy material is limited in an amount of titanium to 0.05 wt %.

4. The device of claim 1 , wherein the alloy material further comprises molybdenum as a constituent.

5. The device of claim 1 , wherein the alloy material comprises the following constituents:
25 wt %-45 wt % cobalt;
25 wt %-45 wt % nickel;
10 wt %-30 wt % chromium; and
0 wt %-20 wt % molybdenum; and
a remainder being limited to a total of 5 wt %.

6. The device of claim 5 , the remainder being limited to a total of 3 wt %.

7. The device of claim 1 , wherein the wall comprises a surface portion including the wetted surface and a bulk portion, and wherein the composition of the alloy material of the wetted surface is different than a composition of a material of the bulk portion.

8. The device of claim 7 , wherein the surface portion is diffusion bonded to the bulk portion.

9. The device of claim 7 , wherein the surface portion consists of the alloy material.

10. The device of claim 1 , wherein the device is configured to withstand pressures of 6,000 psi to 15,000 psi during use.

11. The device of claim 1 , wherein the device is configured to withstand pressures of 15,000 to 20,000 psi.

12. The device of claim 1 , wherein the wetted surface of the wall defines a separation channel.

13. The device of claim 12 , further comprising an end fitting, wherein exterior surfaces of the end fitting exposed to the mobile phase comprise the alloy material.

14. The device of claim 12 , further comprising a frit, wherein exterior surfaces of the frit exposed to the mobile phase comprise the alloy material.

15. The device of claim 12 , further comprising a weir, wherein exterior surfaces of the weir exposed to the mobile phase comprise the alloy material.

16. The device of claim 12 , wherein the device is a microfluidic device and the width or diameter of the separation channel falls in a range of 20 μm to 500 μm.

17. The device of claim 12 , wherein the device comprises two or more sheets of the alloy material, a portion of each sheet forming a portion of the wall, the two or more sheets being diffusion bonded at an interface with at least a portion of the separation channel extending along the interface.

18. The device of claim 12 , wherein the device comprises two or more sheets, each sheet including a layer of the alloy material, each sheet forming a portion of the wall with the layer of alloy material of the sheet forming the wetted surface for the portion of the wall, the layers of the alloy material of the two or more sheets being diffusion bonded at an interface with at least a portion of the separation channel extending along the interface.

19. The device of claim 1 , wherein the alloy material is resistant to adsorption of histidine-containing peptides.

20. The device of claim 1 , wherein over 95% of the surface area of the wetted surface consists of the alloy material.

Assignees

• Waters Technologies Corp

Inventors

• Belanger Jonathan L
• Yang Hua
• Bouvier Edouard S P
• Delano Mathew
• Fisk Raymond P
• Hewitson Hillary B
• Leveille Wade P
• Wyndham Kevin Daniel

Classifications

• B01D2253/1122

  Metals · CPC title

• C12M21/18

  Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes · CPC title

• B01D53/02

  by adsorption, e.g. preparative gas chromatography {(solid sorbent compositions B01J20/00, preparation of inorganic compounds or elements C01)} · CPC title

• C12M23/20

  Material Coatings (immunocoatings C12M25/00) · CPC title

• G01N30/7266

  by electric field, e.g. electrospray · CPC title