Avoidance of peripheral nerve stimulation (PNS) using induced analgesia

Patent metadata

Field	Value
Publication number	US-11511113-B2
Application number	US-201916543064-A
Country	US
Kind code	B2
Filing date	Aug 16, 2019
Priority date	Aug 16, 2019
Publication date	Nov 29, 2022
Grant date	Nov 29, 2022

Abstract

Techniques are disclosed related to increasing prior limits imposed on MR gradient switching speed (dB/dt) without causing significant discomfort or severe pain perception to patients. The technique disclosed herein do so by modifying the pulsing gradient fields that are ordinarily available for MR imaging protocols. Doing so stimulates the peripheral nerves and thus enables a quick, reversible, and complete inhibition of action potential propagation through the stimulated region of tissue, referred to as a nerve conduction block.

First claim

What is claimed is:

1. A magnetic resonance (MR) apparatus for inducing electrical stimulation to inhibit pain perceived by a patient caused by peripheral nerve stimulation (PNS) during a magnetic resonance scan, comprising:
a magnetic resonance data acquisition scanner comprising a gradient coil system including a plurality of coil windings; and
a plurality of gradient amplifiers, each one of the plurality of gradient amplifiers being coupled to a sequence controller and to a respective one of the plurality of coil windings,
wherein the sequence controller is configured to control each respective one of the plurality of gradient amplifiers to cause one or more of the plurality of coil windings to (i) respectively generate timed gradient pulses, and (ii) when it is determined via a control computer associated with the MR apparatus that the frequency of the one or more of the timed gradient pulses in accordance with the timing of an MR sequence is less than a predetermined frequency, to generate one or more dark-mode gradient pulses that are inserted between the one or more of the timed gradient pulses, and
wherein one or more of the timed gradient pulses are generated with one or more time-varying parameters such that, when the patient is exposed to the one or more of the timed gradient pulses and/or the one or more dark-mode gradient pulses, electrical stimulation is induced in at least one region of the patient resulting in an electrically-induced analgesia at the at least one region of the patient during the MR scan.

2. The MR apparatus of claim 1 , wherein:
the one or more of the timed gradient pulses are generated during an MR sequence within a plurality of successive time windows, and
the time-varying parameters include a frequency of the one or more of the timed gradient pulses such that the one or more of the timed gradient pulses are generated having a first frequency within a first time window from among the plurality of successive time windows and a second frequency within a second time window from among the plurality of successive time windows.

3. The MR apparatus of claim 2 , wherein the first time window and the second time window are chronologically-adjacent, and
wherein the first frequency is different than the second frequency.

4. The MR apparatus of claim 3 , wherein the first frequency is within a range of 1 Hz-5 Hz, and
wherein the second frequency is within a range of 1 Hz-150 Hz.

5. The MR apparatus of claim 1 , wherein the time-varying parameters include an amplitude and/or a switching time of the one or more of the timed gradient pulses such that, within a time window during the MR scan, a first portion of the one or more of the timed gradient pulses has a different amplitude and shape than a second portion of the one or more of the timed gradient pulses.

6. The MR apparatus of claim 5 , wherein each of the one or more of the timed gradient pulses within the time window during the MR scan have an equal area below each respective pulse envelope.

7. The MR apparatus of claim 5 , wherein the first portion of the one or more of the timed gradient pulses are generated having a different amplitude and shape than the second portion of the one or more timed gradient pulses within the time window during the MR scan in response to a determination, via a control computer, that the frequency of the one or more of the timed gradient pulses in accordance with the timing of an MR sequence is greater than a predetermined frequency.

8. The MR apparatus of claim 1 , wherein the time-varying parameters include superimposing one or more pulses over a phase-encoding gradient pulse that is applied during phase encoding, the one or more superimposed pulses having a different amplitude and frequency than the phase-encoding gradient pulse to generate the one or more dark-mode gradient pulses, and
wherein an area below a pulse envelope associated with each respective one of the one or more dark-mode gradient pulses is equal to an area below a pulse envelope associated with a respective phase-encoding gradient pulse.

9. The MR apparatus of claim 1 , wherein the time-varying parameters include superimposing one or more pulses over a readout gradient pulse that is applied during frequency encoding, the one or more superimposed pulses having a different amplitude and frequency than the readout gradient pulse to generate the one or more dark-mode gradient pulses, and
wherein an area below a pulse envelope associated with each respective one of the one or more dark-mode gradient pulses is equal to an area below a pulse envelope associated with a respective readout gradient pulse.

10. A non-transitory computer readable medium loaded onto a control computer of a magnetic resonance (MR) data acquisition scanner for inducing electrical stimulation to inhibit pain perceived by a patient caused by peripheral nerve stimulation (PNS) during a MR scan, the non-transitory computer readable medium having instructions stored thereon that, when executed by the control computer, cause the MR data acquisition scanner to:
control a sequence controller that is coupled to each one of a plurality of gradient amplifiers, each one of a plurality of gradient amplifiers being further coupled to a respective one of the plurality of coil windings of a gradient coil system,
wherein control of the sequence controller causes each respective one of the plurality of gradient amplifiers to cause one or more of the plurality of coil windings to (i) respectively generate timed gradient pulses, and (ii) when it is determined via a control computer associated with the MR apparatus that the frequency of the one or more of the timed gradient pulses in accordance with the timing of an MR sequence is less than a predetermined frequency, to generate one or more dark-mode gradient pulses that are inserted between the one or more of the timed gradient pulses, and
wherein one or more of the timed gradient pulses are generated with one or more time-varying parameters such that, when the patient is exposed to the one or more of the timed gradient pulses and/or the one or more dark-mode gradient pulses, electrical stimulation is induced in at least one region of the patient resulting in an electrically-induced analgesia at the at least one region of the patient during the MR scan.

11. The non-transitory computer readable medium as claimed in claim 10 , wherein:
the one or more of the timed gradient pulses are generated during an MR sequence within a plurality of successive time windows, and
the time-varying parameters include a frequency of the one or more of the timed gradient pulses such that the one or more of the timed gradient pulses are generated having a first frequency within a first time window from among the plurality of successive time windows and a second frequency within a second time window from among the plurality of successive time windows.

12. The non-transitory computer readable medium as claimed in claim 11 , wherein the first time window and the second time window are chronologically-adjacent, and
wherein the first frequency is different than the second frequency.

13. The non-transitory computer readable medium as claimed in claim 12 , wherein the first frequency is within a range of 1 Hz-5 Hz, and
wherein the second frequency is within a range of 1 Hz-150 Hz.

14. The non-transitory computer readable medium as claimed in claim 10 , wherein the time-varying parameters include an amplitude and/or a switching time of the one or more of the timed gradient pulses such that, within a time window during the MR scan, a first portion of the one or more of the timed g

Assignees

• Siemens Healthcare Gmbh
• Massachusetts Gen Hospital

Inventors

• Popescu Stefan
• Wald Lawrence
• Rosen Bruce
• Stockmann Jason

Classifications

• A61N1/36057

  adapted for stimulating afferent nerves · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61N1/36071 Primary

  Pain · CPC title

• G01R33/0082

  Compensation, e.g. compensating for temperature changes · CPC title