Medical multi-layer product comprising nanofibrillar cellulose and method for preparing thereof

Patent metadata

Field	Value
Publication number	US-11511015-B2
Application number	US-201616065233-A
Country	US
Kind code	B2
Filing date	Dec 30, 2016
Priority date	Dec 31, 2015
Publication date	Nov 29, 2022
Grant date	Nov 29, 2022

Abstract

The present application provides a medical multi-layer product comprising a layer comprising nanofibrillar cellulose, and a layer of gauze. The present application also provides a medical product comprising the medical multi-layer product, and a cosmetic product comprising the medical multi-layer product. The present application also provides a method for preparing a medical multi-layer product, the method comprising providing a filter, providing a dispersion comprising nanofibrillar cellulose, providing a gauze, applying the dispersion onto the filter, applying the gauze onto the dispersion, and dewatering the structure through the filter to obtain the medical multi-layer product.

First claim

The invention claimed is:

1. A medical multi-layer product comprising
a first layer comprising plant nanofibrillar cellulose having a moisture content in the range of 0-10% (w/w), and
a layer of gauze;
wherein the product has a tear index in the range of 18-100 mNm 2 /q.

2. The medical multi-layer product of claim 1 , wherein the first layer comprising plant nanofibrillar cellulose has a moisture content in the range of 5-7% (w/w).

3. The medical multi-layer product of claim 1 , comprising
a second layer comprising nanofibrillar cellulose.

4. The medical multi-layer product of claim 3 , wherein the plant nanofibrillar cellulose in the first layer and/or in the second layer, when dispersed in water, provides a Brookfield viscosity of at least 2000 mPa·s, measured at a consistency of 0.8% (w/w) and at 10 rpm.

5. The medical multi-layer product of claim 1 , wherein the gauze comprises natural gauze.

6. The medical multi-layer product of claim 1 , wherein the gauze comprises synthetic gauze or semi-synthetic.

7. The medical multi-layer product of claim 1 , wherein the plant nanofibrillar cellulose comprises non-modified nanofibrillar cellulose.

8. The medical multi-layer product of claim 1 , wherein the plant nanofibrillar cellulose comprises chemically modified plant nanofibrillar cellulose.

9. The medical multi-layer product of claim 1 , wherein a layer of plant nanofibrillar cellulose has a thickness in the range of 5-60 μm.

10. The medical multi-layer product of claim 1 , having a thickness in the range of 100-500 μm.

11. The medical multi-layer product of claim 1 , wherein the first layer comprising t nanofibrillar cellulose comprises an amount of non-nanofibrillar pulp in the range of 0.1-60% (w/w) of total cellulose in said layer.

12. The medical multi-layer product of claim 1 , wherein product has a grammage in the range of 50-100 g/m 2 .

13. The medical multi-layer product of claim 1 wherein the product has a density in the range of 300-800 kg/m 3 .

14. The medical multi-layer product of claim 1 , wherein the plant nanofibrillar cellulose in the first layer has a number average diameter of a fibril in the range of 1-100 nanometers.

15. The medical multi-layer product of claim 1 comprising a therapeutic agent.

16. The medical multi-layer product of claim 1 comprising a cosmetic agent.

17. A medical product comprising the medical multi-layer product of claim 1 .

18. A method for treating skin wounds or other damages or injuries, the method comprising applying the medical multi-layer product of claim 1 onto the wound, damage, or injury.

19. A method for treating skin wounds covered with a graft the method comprising applying the medical multi-layer product of claim 1 onto the graft.

20. A method for administering therapeutic agent, the method comprising applying the medical multi-layer product of claim 15 onto skin.

21. A method for preparing a medical multi-layer product, the method comprising
providing a filter,
providing a dispersion comprising plant nanofibrillar cellulose,
providing a gauze,
applying the dispersion onto the filter,
applying the gauze onto the dispersion to form a structure, and
dewatering the structure through the filter to obtain the medical multi-layer product comprising a first layer comprising plant nanofibrillar cellulose having a moisture content in the range of 0-10% (w/w).

22. The method of claim 21 , further comprising providing a second dispersion comprising nanofibrillar cellulose and applying the second dispersion comprising nanofibrillar cellulose onto the gauze.

23. A medical multi-layer product comprising
a first layer comprising plant nanofibrillar cellulose having a moisture content in the range of 0-10% (w/w), and
a layer of gauze;
wherein the product has a tear index in the range of 18-100 mNm 2 /g, and
wherein the product is obtained with the method of claim 21 .

24. A method for preparing a medical multi-layer product, the method comprising
providing a first layer comprising plant nanofibrillar cellulose having a moisture content in the range of 0-10% (w/w),
providing a layer of gauze, and
laminating the first layer comprising plant nanofibrillar cellulose and the layer of gauze to obtain the medical multi-layer product;
wherein the product has a tear index in the range of 18-100 mNm 2 /q.

25. The method of claim 24 , wherein the first layer comprising plant nanofibrillar cellulose has a moisture content in the range of 1-10%.

26. The method of claim 24 , wherein the gauze comprises natural gauze.

27. The method of claim 24 , wherein the gauze comprises synthetic gauze or semi-synthetic.

28. The method of claim 24 , wherein the plant nanofibrillar cellulose in the first layer comprising plant nanofibrillar cellulose when dispersed in water, provides a Brookfield viscosity of at least 2000 mPa·s, measured at a consistency of 0.8% (w/w) and at 10 rpm.

29. The method of claim 24 , wherein the first layer comprising plant nanofibrillar cellulose comprises non-modified plant nanofibrillar cellulose.

30. The method of claim 24 , wherein the first layer comprising plant nanofibrillar cellulose comprises chemically modified plant nanofibrillar cellulose.

31. The method of claim 24 , wherein the first layer comprising plant nanofibrillar cellulose comprises an amount of non-nanofibrillar pulp in the range of 0.1-60% (w/w) of total cellulose in said layer.

32. The method of claim 24 , comprising providing a therapeutic agent and including the therapeutic agent to the first layer comprising plant nanofibrillar cellulose.

33. The method of claim 24 , comprising providing a cosmetic agent and including the cosmetic agent to the first layer comprising plant nanofibrillar cellulose.

Assignees

• Upm Kymmene Corp

Inventors

• Kosonen Mika
• Luukko Kari

Classifications

• A61L15/60

  Liquid-swellable gel-forming materials, e.g. super-absorbents · CPC title

• A61L27/60

  Materials for use in artificial skin · CPC title

• A61L27/20

  Polysaccharides · CPC title

• A61F13/00987

  Apparatus or processes for manufacturing non-adhesive dressings or bandages · CPC title

• A61L15/28 Primary

  Polysaccharides or their derivatives {(A61L15/225 takes precedence)} · CPC title