Method for preparing a vaccine antigen, resulting vaccine antigen and uses
US-10144917-B2 · Dec 4, 2018 · US
US11510896B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11510896-B2 |
| Application number | US-201716340346-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 20, 2017 |
| Priority date | Oct 21, 2016 |
| Publication date | Nov 29, 2022 |
| Grant date | Nov 29, 2022 |
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The present invention relates to a pharmaceutical or veterinary composition for its use in preventing and/or treating a MERS-CoV (Middle-East Respiratory Syndrome) coronavirus infection, characterised in that it comprises, in a suitable pharmaceutical vehicle, at least one compound chosen from apigenin and berberine.
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The invention claimed is: 1. A method for treating a MERS-CoV (Middle-East Respiratory Syndrome) coronavirus infection of a human being or an animal comprising the administration to said human being or animal of a pharmaceutical or veterinary composition comprising, in a suitable pharmaceutical vehicle, at least one compound chosen from Apigenin and Berberine. 2. The method of claim 1 , wherein the pharmaceutical or veterinary composition comprises Apigenin. 3. The method of claim 1 , wherein the pharmaceutical or veterinary composition comprises Berberine. 4. The method of claim 2 , wherein the pharmaceutical or veterinary composition comprises one of the following combinations: Apigenin and Berberine; Apigenin and Monensin; or Apigenin, Berberine and Monensin. 5. The method of claim 1 , comprising an antiviral agent chosen from the group consisting of a protease inhibitor, a helicase inhibitor, and a MERS-CoV virus cell entry inhibitor. 6. The method of claim 1 , comprising an antiviral agent chosen from the group consisting of ribavirin and an interferon. 7. The method of claim 6 , wherein the interferon is interferon alpha-2b. 8. The method of claim 1 , wherein the pharmaceutical or veterinary composition is in a dosage form intended for administration by inhalation.
for RNA viruses · CPC title
not condensed with another ring · CPC title
Interferons {[IFN]} · CPC title
3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine · CPC title
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