Control device, control method, computer program, and method for producing organic compound

Patent metadata

Field	Value
Publication number	US-11505778-B2
Application number	US-202016829737-A
Country	US
Kind code	B2
Filing date	Mar 25, 2020
Priority date	Mar 29, 2019
Publication date	Nov 22, 2022
Grant date	Nov 22, 2022

Abstract

A control device performs control of a culture condition in production of an organic compound by a fermentation method. The control device executes processing a plurality of times to acquire culture data, to calculate, using the acquired culture data, a plurality of candidates for a culture condition set in advance, and a linear model set in advance that outputs a production amount of an organic compound at a future time, the production amount at the future time for each of the candidates, to determine an optimum candidate out of the candidates using the calculated production amount at the future time for each of the candidates and a target production amount of the organic compound at the future time set in advance, and to change the culture condition to the determined candidate. The linear model and the target production amount are set for each time.

First claim

What is claimed is:

1. A control device comprising circuitry or a processor configured to perform control of a culture condition in production of an organic compound by a fermentation method,
the circuitry or the processor of the control device being configured to execute processing a plurality of times to acquire culture data, to calculate, using the acquired culture data, a plurality of candidates for a culture condition set in advance, and a linear model set in advance that outputs a production amount of an organic compound at a future time, the production amount at the future time for each of the candidates, to determine an optimum candidate out of the candidates using the calculated production amount at the future time for each of the candidates and a target production amount of the organic compound at the future time set in advance, and to change the culture condition to the determined candidate, and
the linear model and the target production amount being set for each time.

2. The control device according to claim 1 , wherein the future time is a time when next time processing is executed.

3. The control device according to claim 1 , determining a candidate corresponding to a production amount at the future time closest to the target production amount to be the optimum candidate.

4. The control device according to claim 1 , wherein
a plurality of the linear models are set for each time, and
the optimum candidate is determined out of the candidates using a sample statistical amount for each of the candidates based on a plurality of production amounts at the future time for each of the candidates and the target production amount.

5. The control device according to claim 1 , wherein the linear model is a multiple regression formula.

6. The control device according to claim 1 , wherein the organic compound is an amino acid.

7. The control device according to claim 6 , wherein the amino acid is a basic amino acid.

8. The control device according to claim 7 , wherein the basic amino acid is lysine or arginine.

9. The control device according to claim 1 , wherein the culture condition includes a condition on temperature, pH, or a phosphoric acid concentration.

10. A control method executed by a control device that performs control of a culture condition in production of an organic compound by a fermentation method,
the control device executing processing a plurality of times to acquire culture data, to calculate, using the acquired culture data, a plurality of candidates for a culture condition set in advance, and a linear model set in advance that outputs a production amount of an organic compound at a future time, the production amount at the future time for each of the candidates, to determine an optimum candidate out of the candidates using the calculated production amount at the future time for each of the candidates and a target production amount of the organic compound at the future time set in advance, and to change the culture condition to the determined candidate, and
the linear model and the target production amount being set for each time.

11. A non-transitory computer-readable storage medium storing computer-readable instructions that, when executed by a computer, cause the computer to cause a control device that performs control of a culture condition in production of an organic compound by a fermentation method to execute
processing a plurality of times to acquire culture data, to calculate, using the acquired culture data, a plurality of candidates for a culture condition set in advance, and a linear model set in advance that outputs a production amount of an organic compound at a future time, the production amount at the future time for each of the candidates, to determine an optimum candidate out of the candidates using the calculated production amount at the future time for each of the candidates and a target production amount of the organic compound at the future time set in advance, and to change the culture condition to the determined candidate, and
the linear model and the target production amount being set for each time.

12. A method for producing an organic compound, the method comprising producing an organic compound with a production system having the control device according to claim 1 .

13. The method according to claim 12 , wherein the organic compound is an amino acid.

14. The method according to claim 13 , wherein the amino acid is a basic amino acid.

15. The method according to claim 14 , wherein the basic acid is lysine or arginine.

Assignees

• Ajinomoto Kk

Inventors

• Shimodaira Yoshiki
• Kobayashi Hiroki
• Terawaki Takahiro
• Kusunose Yasuhiro

Classifications

• C12M41/12

  of temperature (controlling the temperature of chemical or physical processes B01J19/0013, heating or cooling apparatus for laboratory use B01L7/00) · CPC title

• G05B15/02

  electric · CPC title

• C12M41/32 Primary

  of substances in solution · CPC title

• C12P13/08

  Lysine; Diaminopimelic acid; Threonine; Valine · CPC title

• C12M41/26

  of pH · CPC title