Automatic analysis apparatus and method for controlling automatic analysis apparatus

Patent metadata

Field	Value
Publication number	US-11499983-B2
Application number	US-201816956665-A
Country	US
Kind code	B2
Filing date	Nov 19, 2018
Priority date	Jan 26, 2018
Publication date	Nov 15, 2022
Grant date	Nov 15, 2022

Abstract

[Task] To provide an automatic analysis apparatus including a photomultiplier tube which controls a sensitivity of the photomultiplier tube without adjusting a high voltage value. [Solution] An automatic analysis apparatus according to the present invention includes a photomultiplier tube which detects light from a reaction vessel; a determination unit which determines an output signal of the photomultiplier tube in a case where the photomultiplier tube is irradiated with first light; and a control unit which irradiates the photomultiplier tube with second light to lower a sensitivity of the photomultiplier tube in accordance with a determination result by the determination unit.

First claim

The invention claimed is:

1. An automatic analysis apparatus, comprising:
a photomultiplier tube configured to detect light from a reaction vessel;
a light source; and
a controller programmed to determine an output signal of the photomultiplier tube in a case where the photomultiplier tube is irradiated with a first light from the light source, determine a target irradiation amount of the photomultiplier tube with a second light from the light source to lower a sensitivity of the photomultiplier tube based on the output signal, and continuously irradiate the photomultiplier tube with the second light until the target radiation amount is reached and the sensitivity of the photomultiplier tube reaches a target value.

2. The automatic analysis apparatus according to claim 1 , wherein the controller is programmed to:
compare the target value with the output signal of the photomultiplier tube after irradiating the photomultiplier tube with the second light,
control irradiation of the photomultiplier tube with the second light continuously when the output signal is equal to or less than the target value, and
terminate the irradiation of the photomultiplier tube with the second light when the output signal is equal to or less than the target value.

3. The automatic analysis apparatus according to claim 1 , wherein a light amount per unit time of the second light is at least 10 times greater than a light amount per unit time of the first light.

4. The automatic analysis apparatus according to claim 1 , wherein the first light and the second light are emitted from the same light source.

5. The automatic analysis apparatus according to claim 1 , further comprising:
a first chamber including the light source;
a second chamber adjacent to the first chamber and configured to hold the reaction vessel; and
a third chamber adjacent to the second chamber and including the photomultiplier tube,
wherein the controller is programmed to determine the output signal by irradiating the photomultiplier tube in the third chamber with the first light from the light source in the first chamber via the second chamber after the reaction vessel is evacuated from the second chamber.

6. The automatic analysis apparatus according to claim 5 , further comprising:
a neutral density filter which is arranged between the light source and the second chamber and is configured to vary a transmittance of the light from the light source.

7. The automatic analysis apparatus according to claim 1 , wherein the controller is programmed to correct measurement values of the photomultiplier tube.

8. The automatic analysis apparatus according to claim 1 , wherein the first light is light emitted from a reagent.

9. The automatic analysis apparatus according to claim 1 , further comprising:
a display screen configured to display a warning when the sensitivity of the photomultiplier tube after being irradiated with the first light is greater than the sensitivity of the photomultiplier tube before being irradiated with the first light.

10. The automatic analysis apparatus according to claim 1 , further comprising:
a display screen configured to display a warning when a total value of irradiation amounts of the second light to the photomultiplier tube exceeds a certain value.

11. The automatic analysis apparatus according to claim 1 , wherein the controller is programmed to interrupt the irradiation of the second light when an instruction to interrupt irradiation and lower the sensitivity of the photomultiplier tube is issued.

12. The automatic analysis apparatus according to claim 1 , further comprising:
a memory configured to store an irradiation amount of the second light to the photomultiplier tube.

13. A method for controlling an automatic analysis apparatus including a photomultiplier tube configured to detect light from a reaction vessel, a light source, and a controller programmed to determine an output signal of the photomultiplier tube, the method comprising steps of:
irradiating the photomultiplier tube with a first light from the light source;
determining the output signal of the photomultiplier tube in a case where the photomultiplier tube is irradiated with the first light;
determining a target irradiation amount of the photomultiplier tube with a second light from the light source to lower a sensitivity of the photomultiplier tube based on the output signal; and
continuously irradiating the photomultiplier tube with the second until the target radiation amount is reached and the sensitivity of the photomultiplier tube reaches a target value.

14. The method for controlling the automatic analysis apparatus according to claim 13 , wherein the target value is compared with the output signal of the photomultiplier tube after irradiating the photomultiplier tube with the second light, and
when the output signal is greater than the target value, irradiating the photomultiplier tube with the second light is continuously performed, and when the output signal is equal to or less than the target value, irradiating the photomultiplier tube with the second light is terminated.

Assignees

• Hitachi High Tech Corp

Inventors

• NOBUKI Shunichirou
• Hamasaki Koshin
• Sakazume Taku
• Yamashita Yoshihiro
• Tanoue Hidetsugu
• TAKAKURA Tatsuki

Classifications

• G01J2001/444

  Compensating; Calibrating, e.g. dark current, temperature drift, noise reduction or baseline correction; Adjusting · CPC title

• G01J1/044

  using shutters · CPC title

• G01J1/42

  using electric radiation detectors (optical or mechanical part G01J1/04; by comparison with a reference light or electric value G01J1/10) · CPC title

• G01J1/0418

  using attenuators · CPC title

• G01J1/08

  Arrangements of light sources specially adapted for photometry {standard sources, also using luminescent or radioactive material} · CPC title