Fibrous membrane for biomedical application based on poly(ester-amide)s
US-8974815-B2 · Mar 10, 2015 · US
US11499008B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11499008-B2 |
| Application number | US-201816483122-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 2, 2018 |
| Priority date | Feb 2, 2017 |
| Publication date | Nov 15, 2022 |
| Grant date | Nov 15, 2022 |
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An end and monomer functionalized poly(propylene fumarate) polymer and methods for preparing this polymer, comprising isomerized residue of a maleic anhydride monomer and a functionalized propylene oxide monomer according to the formula:where n is an integer from more than 1 to 100; R is the residue of an initiating alcohol having a propargyl, norbornene, ketone or benzyl functional group; and R′ is a second functional group selected from the group consisting of propargyl groups, 2-nitrophenyl groups, and combinations thereof are disclosed. The end and monomer functional groups allow for post-polymerization modification with bioactive materials using “click” chemistries and use of the polymer for a variety of applications in medical fields, including, for example, 3-D printed polymer scaffold.
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What is claimed is: 1. An end and monomer functionalized poly(propylene fumarate) polymer comprising an isomerized residue of a maleic anhydride monomer and a functionalized propylene oxide monomer having the formula: where n is an integer from more than 1 to 100; R is the residue of an initiating alcohol having a propargyl, norbornene, ketone or benzyl functional group; and R′ is a second functional group selected from the group consisting of propargyl groups, 2-nitrophenyl groups, and combinations thereof. 2. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 3. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 4. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 5. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 6. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 7. The end and monomer functionalized polypropylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100. 8. The end and monomer functionalized poly(propylene fumarate) polymer of claim 1 having the formula: where n is an integer from about more than 1 to about 100.
Alkali metals, alkaline earth metals, beryllium, magnesium, copper, silver, gold, zinc, cadmium, mercury, manganese, or compounds thereof {(C08G63/823 takes precedence)} · CPC title
Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation · CPC title
Lactones or lactides · CPC title
Polymers modified by chemical after-treatment · CPC title
acyclic · CPC title
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