Methods and apparatus for rapid heating of biological specimens

Patent metadata

Field	Value
Publication number	US-11498076-B2
Application number	US-201816608141-A
Country	US
Kind code	B2
Filing date	May 2, 2018
Priority date	May 9, 2017
Publication date	Nov 15, 2022
Grant date	Nov 15, 2022

Abstract

Methods of pre-heating a test vessel prior to transfer of the test vessel to an incubator may shorten an incubation cycle, ensure proper temperature of a test specimen in the test vessel, and/or improve testing accuracy and/or throughput in a bio-liquid specimen testing apparatus. The methods include providing a test vessel pre-heating apparatus having a receptacle sized to receive a test vessel therein and having at least one heating unit configured to heat by direct conduction at least one side of the test vessel. The methods also include heating at least one side of the test vessel via direct contact using the at least one heating unit. Specimen testing apparatus and test vessel pre-heating apparatus configured to carry out the method are described, as are other aspects.

First claim

What is claimed is:

1. A heating apparatus of a specimen testing apparatus, the specimen testing apparatus including a sample rack of bio-liquid containers and an incubator, the heating apparatus comprising:
a test vessel pre-heating apparatus comprising:
a receptacle sized to receive a test vessel therein; and
at least one heating unit positioned inside the receptacle and configured to be in direct contact with, and to heat by direct contact, a side of the test vessel;
wherein the receptacle comprises at least one movable wall configured to clamp the at least one heating unit against the side of the test vessel.

2. The heating apparatus of claim 1 , wherein the at least one heating unit comprises a heatable plate or a Peltier heater operative to heat and to cool.

3. The heating apparatus of claim 1 , wherein the at least one heating unit comprises a pair of heating units configured to heat by direct contact opposite sides of the test vessel.

4. The heating apparatus of claim 1 , further comprising an actuator configured to move the at least one movable wall, and a controller configured to operate the actuator.

5. The heating apparatus of claim 1 , further comprising a temperature controller configured to receive temperature values from one or more temperature sensors and to control an amount of heat provided by the at least one heating unit in response to the temperature values.

6. The heating apparatus of claim 5 , wherein the one or more temperature sensors comprise a thermocouple, resistive temperature device, thermistor, or an infrared sensor.

7. The heating apparatus of claim 1 , wherein the at least one heating unit comprises a pliable thermally conductive insulator in contact with the side of the test vessel.

8. The heating apparatus of claim 7 , wherein the pliable thermally conductive insulator comprises an elastomer material.

9. A heating apparatus of a specimen testing apparatus, the specimen testing apparatus including a sample rack of bio-liquid containers and an incubator, the heating apparatus comprising:
a test vessel pre-heating apparatus comprising:
a receptacle sized to receive a test vessel therein; and
at least one heating unit positioned inside the receptacle and configured to be in direct contact with, and to heat by direct contact, a side of the test vessel; wherein the at least one heating unit comprises:
a heatable plate or a Peltier heater operative to heat and to cool; and
a pliable thermally conductive insulator configured to be attached to the heatable plate or Peltier heater and to be in contact with the side of the test vessel.

10. The heating apparatus of claim 9 , wherein the pliable thermally conductive insulator comprises an elastomer material.

11. The heating apparatus of claim 9 , further comprising a temperature controller configured to receive temperature values from one or more temperature sensors and to control an amount of heat provided by the at least one heating unit in response to the temperature values.

12. The heating apparatus of claim 11 , wherein the one or more temperature sensors comprise a thermocouple, resistive temperature device, thermistor, or an infrared sensor.

Assignees

• Siemens Healthcare Diagnostics Inc

Inventors

• Dulaff Paul
• Delametter Christopher

Classifications

• B01L2300/1805

  Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks · CPC title

• B01L2300/1827

  using resistive heater · CPC title

• B01L7/02 Primary

  Water baths; Sand baths; Air baths · CPC title

• G01N35/025

  having a carousel or turntable for reaction cells or cuvettes · CPC title

• B01L7/00 Primary

  Heating or cooling apparatus (autoclaves B01J3/04); Heat insulating devices · CPC title