Simulating a target coverage for deep brain stimulation

Patent metadata

Field	Value
Publication number	US-11495345-B2
Application number	US-202016828484-A
Country	US
Kind code	B2
Filing date	Mar 24, 2020
Priority date	Dec 16, 2015
Publication date	Nov 8, 2022
Grant date	Nov 8, 2022

Abstract

A system is disclosed for determining a coverage of a target anatomical structure by an electric stimulation field. The system includes a computer to acquire patient image data and the atlas data, determine, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient. The system also acquires electrode position data and stimulation field data describing an electric stimulation field around the position of the electrode. The system also includes an electrode configuring device for adjusting an emission configuration of the electrode.

First claim

The invention claimed is:

1. A system for determining a coverage of a target anatomical structure by an electric stimulation field, the system comprising:
at least one electronic data storage device storing:
patient image data describing a medical image of an anatomical body part of a patient, wherein the anatomical body part includes the target anatomical structure;
atlas data describing a model of the anatomical body part and information about a position of a model target structure in the model of the anatomical body part, the model target structure corresponding to the target anatomical structure wherein the model of the anatomical body part is an image based model; and
electrode position data describing a relative position between a position of an electrode and a position of the anatomical body part of the patient as it is described by the patient image data;
at least one computer including at least one processor and associated memory that executes instructions to:
acquire the patient image data and the atlas data;
determine, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient;
acquire, from an at least one database, the electrode position data;
acquire stimulation field data describing the electric stimulation field around the position of the electrode;
determine, by the at least one processor and based on the patient image data and the atlas data and the electrode position data and the stimulation field data, target coverage data describing a coverage of the target anatomical structure by the electric stimulation field, and determining, by the at least one processor and based on the patient image data and the atlas data, body part transformation data describing a positional transformation between the medical image of the anatomical body part and the model of the anatomical body part, wherein the target coverage data is determined further based on the body part transformation data;

wherein the target coverage data is determined for use in deep brain stimulation of the target anatomical structure by the electric stimulation field of the electrode, and
an electrode configuring device for adjusting an emission configuration of the electrode;
wherein the at least one computer is operatively coupled to the electrode configuring device for transmission of the stimulation field data to the electrode configuring device in order to configure the electrode to emit the electric stimulation field described by the stimulation field data.

2. The system according to claim 1 , wherein the image based model of the anatomical body part is generated from a statistical analysis of images taken for a plurality of patients.

3. The system according to claim 1 , wherein the body part transformation data is determined by applying an image fusion algorithm to the patient image data and the atlas data.

4. The system according to claim 1 , wherein the electrode is a directional electrode having a plurality of electrically emitting contacts, and wherein the electric stimulation field is adjusted by adjusting a distribution of electric energy onto the plurality of electrically emitting contacts.

5. The system according to claim 1 , further comprising instructions operable to:
acquire, at the at least one processor, electrode image data describing a second medical image of the electrode in the anatomical body part of the patient and specifically a relative position between the position of the electrode and the position of the anatomical body part in the second medical image;
determine, by the at least one processor and based on the electrode image data and the atlas data, electrode transformation data describing a positional transformation between the position of the anatomical body part as it is described by the second medical image and the position of the model of the anatomical body part;
wherein the electrode position data is determined, by the at least one processor, based on the electrode image data and the electrode transformation data and the body part transformation data.

6. The system according to claim 5 , wherein the electrode transformation data is determined by applying an image fusion algorithm to the electrode image data and the atlas data.

7. The system according to claim 5 , wherein the model of the anatomical body part is suitable for comparison with medical image data taken with two different medical imaging modalities, wherein the atlas data describes a multi-modal atlas of the anatomical body part.

8. The system according to claim 7 , further comprising instructions operable to:
determine, by the at least one processor and based on the patient image data and the target structure position data and the electrode position data, electrode target data describing a relative position between the position of the target anatomical structure and the position of the electrode;
wherein the target coverage data is determined further based on the electrode target data.

9. The system according to claim 1 , further comprising instructions operable to:
acquire, at the at least one processor, desired coverage data describing a desired coverage of the target anatomical structure by the electric stimulation field;
determine, by the at least one processor, coverage difference data describing a difference between the coverage described by the target coverage data and the coverage described by the desired coverage data;
vary, by the at least one processor, the stimulation field data in order to optimize the difference.

10. The system according to claim 1 , wherein the stimulation field data is acquired based on user input.

11. The system according to claim 10 , wherein the user input is manual input of physical values defining the electric stimulation field.

12. A system for determining a coverage of a target anatomical structure by an electric stimulation field, the system comprising:
at least one electronic data storage device storing at least one database comprising:
patient image data describing a medical image of an anatomical body part of a patient, wherein the anatomical body part includes the target anatomical structure,
atlas data describing a model of the anatomical body part and information about a position of a model target structure in the model of the anatomical body part, the model target structure corresponding to the target anatomical structure, wherein the model of the anatomical body part is an image based model, and
electrode position data describing a relative position between a position of an electrode and a position of the anatomical body part of the patient as it is described by the patient image data;

at least one computer including at least one processor that executes instructions stored on a computer readable storage medium to:
acquire, from an at least one database, the patient image data and the atlas data;
determine, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient;
acquire, from the at least one database, the electrode position data;
acquire stimulation field data describing the electric stimulation field around the position of the electrode; and

an electrode configuring device for adjusting an emission configuration of the electrode;
wherein the at least one computer is operatively coupled to the electrode configuring device for transmission of the stimulation field data to the electrode configuring device in order to configure the ele

Assignees

• Brainlab Ag

Inventors

• Achatz Stefan
• Varkuti Bálint

Classifications

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• G16H20/30

  relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising · CPC title

• G16H30/40 Primary

  for processing medical images, e.g. editing · CPC title

• A61N1/36185

  Selection of the electrode configuration · CPC title

• A61N1/37241

  providing test stimulations · CPC title