Aryl or heteroaryl triazolone derivatives or salts thereof, or pharmaceutical compositions comprising the same

Patent metadata

Field	Value
Publication number	US-11492335-B2
Application number	US-202017104557-A
Country	US
Kind code	B2
Filing date	Nov 25, 2020
Priority date	Mar 21, 2018
Publication date	Nov 8, 2022
Grant date	Nov 8, 2022

Abstract

The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

First claim

What is claimed is:

1. A compound of Formula X, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof:

wherein
A is thiazole optionally substituted with one to three substituents chosen from C 1-3 alkyl, C 1-3 alkoxy, halogen, benzyloxy, —R, —CH 2 —R, —CH═CH—R, and —C≡C—R; and
R is substituted or unsubstituted cyclic ring, optionally containing 1 to 5 heteroatom ring members independently chosen from O, N, and S, and the cyclic ring is aromatic or non-aromatic.

2. The compound, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 1 , wherein A is

3. The compound, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 1 , wherein said R is a cyclic ring selected from the group consisting of benzene, phenylbenzene, pyridine, tetrahydropyridine, pyridin-2-one, pyrimidine, thiophene, thiazole, imidazole, pyrazole, piperazine, morpholine, benzodioxole, benzoxadiazole, benzothiophene, benzothiazole, 2,3-dihydro-benzodioxine, indazole, indole, 1,3-dihydroindol-2-one, 1,2-dihydroindol-3-one, quinoline, isoquinoline, quinolin-2-one, 3,4-dihydroquinolin-2-one, 3,4-dihydro-1,4-benzoxazine, 1,4-benzoxazin-3-one, 3,1-benzoxazin-2-one, 2,3-dihydro-imidazo[4,5-b]pyridine, oxazolo[4,5-b]pyridin-2-one, 2,3-dihydro-pyrido[2,3-b][1,4]oxazine, 3,4-dihydro-pyrido[3,2-b][1,4]oxazine, pyrido[2,3-b][1,4]oxazin-2-one, pyrido[3,2-b][1,4]oxazin-3-one, and dibenzo[b,d]furan,
and R is optionally substituted with one or two substituents selected from the group consisting of hydroxy, halogen, C 1-6 alkyl, trifluoromethyl, C 1-6 alkoxy, trifluoromethoxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkylcarbonylamino, C 1-6 alkylthio, mono- or di-C 1-6 alkylaminosulfonyl, C 1-6 alkyl sulfonyl, C 1-6 alkylcarbonyl, morpholinylcarbonyl, benzodioxolyl, pyrrolidinyl, piperazinyl, acetylpiperazinyl, morpholinyl, tetrahydropyranyl, triazolyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, cyclopropyl-oxadiazolyl, C 1-6 alkyl-oxadiazolyl, and oxadiazol-5-onyl.

4. A pharmaceutical composition comprising the compound according to claim 1 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

5. A method of selectively inhibiting vascular adhesion protein (VAP-1), comprising administering, to a mammal in need thereof, a therapeutically effective amount of the compound according to claim 1 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof.

6. A method of treating NASH in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound according to claim 1 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof.

7. A method of treating a disease mediated by VAP-1 in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound according to claim 1 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof.

8. The method according to claim 7 , wherein the disease mediated by VAP-1 is selected from the group consisting of a lipid disorder, lipoprotein disorder, condition or disease which results from chronic fatty or fibrotic degeneration of organs due to accumulated lipid, triglyceride accumulation and subsequent activation of a profibrotic pathway, Type I Diabetes, Type II Diabetes, clinical complication of Type I or Type II Diabetes, chronic intrahepatic cholestatic condition, extrahepatic cholestatic condition, liver fibrosis, acute intrahepatic cholestatic condition, obstructive or chronic inflammatory disorder that arises out of improper bile composition, gastrointestinal condition with a reduced uptake of dietary fat or fat-soluble dietary vitamin, inflammatory bowel disease, obesity, metabolic syndrome, combined conditions of dyslipidemia, diabetes and abnormally high body-mass index, persistent infection by intracellular bacteria or parasitic protozoae, non-malignant hyperproliferative disorder, malignant hyperproliferative disorders, colon adenocarcinoma and hepatocellular carcinoma, liver steatosis or associated syndrome, Hepatitis B infection, Hepatitis C infection, cholestatic and fibrotic effects that are associated with alcohol-induced cirrhosis or with viral-borne forms of hepatitis, liver failure or liver malfunction as an outcome of chronic liver disease or of surgical liver resection, acute myocardial infarction, acute stroke, thrombosis which occurs as an endpoint of chronic obstructive atherosclerosis, osteoarthritis, rheumatoid arthritis, psoriasis, and cerebral infarction, individually or any combination thereof.

9. A compound of Formula X, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof:

wherein
A is pyrazine optionally substituted with one to three substituents chosen from C 1-3 alkyl, C 1-3 alkoxy, halogen, benzyloxy, —R, —CH 2 —R, —CH═CH—R, and —C≡C—R; and
R is substituted or unsubstituted cyclic ring, optionally containing 1 to 5 heteroatom ring members independently chosen from O, N, and S, and the cyclic ring is aromatic or non-aromatic.

10. The compound, or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 9 , wherein said R is a cyclic ring selected from the group consisting of benzene, phenylbenzene, pyridine, tetrahydropyridine, pyridin-2-one, pyrimidine, thiophene, thiazole, imidazole, pyrazole, piperazine, morpholine, benzodioxole, benzoxadiazole, benzothiophene, benzothiazole, 2,3-dihydro-benzodioxine, indazole, indole, 1,3-dihydroindol-2-one, 1,2-dihydroindol-3-one, quinoline, isoquinoline, quinolin-2-one, 3,4-dihydroquinolin-2-one, 3,4-dihydro-1,4-benzoxazine, 1,4-benzoxazin-3-one, 3,1-benzoxazin-2-one, 2,3-dihydro-imidazo[4,5-b]pyridine, oxazolo[4,5-b]pyridin-2-one, 2,3-dihydro-pyrido[2,3-b][1,4]oxazine, 3,4-dihydro-pyrido[3,2-b][1,4]oxazine, pyrido[2,3-b][1,4]oxazin-2-one, pyrido[3,2-b][1,4]oxazin-3-one, and dibenzo[b,d]furan,
and R is optionally substituted with one or two substituents selected from the group consisting of hydroxy, halogen, C 1-6 alkyl, trifluoromethyl, C 1-6 alkoxy, trifluoromethoxy, amino, mono- or di-C 1-6 alkylamino, C 1-6 alkylcarbonylamino, C 1-6 alkylthio, mono- or di-C 1-6 alkylaminosulfonyl, C 1-6 alkyl sulfonyl, C 1-6 alkylcarbonyl, morpholinylcarbonyl, benzodioxolyl, pyrrolidinyl, piperazinyl, acetylpiperazinyl, morpholinyl, tetrahydropyranyl, triazolyl, tetrazolyl, isoxazolyl, oxazolyl, oxadiazolyl, cyclopropyl-oxadiazolyl, C 1-6 alkyl-oxadiazolyl, and oxadiazol-5-onyl.

11. A pharmaceutical composition comprising the compound according to claim 9 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

12. A method of selectively inhibiting vascular adhesion protein (VAP-1), comprising administering, to a mammal in need thereof, a therapeutically effective amount of the compound according to claim 9 , or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof.

13. A method of treating NASH in a subject in need ther

Assignees

• Yuhan Corp

Inventors

• Han Tae Dong
• Tak Hee Jae
• Kim Eun Kyung
• Choi Su Bin
• Kim Dong Hoon
• Park Sol
• Jung Eun Hye
• Choi Hyun Ho
• Kim Tae Wang
• Ju Mi Kyeong
• Ha Na Ry

Classifications

• C07D403/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D417/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D417/14

  containing three or more hetero rings · CPC title

• C07D403/14

  containing three or more hetero rings · CPC title

• C07D409/10

  linked by a carbon chain containing aromatic rings · CPC title