Glucocorticoid receptor agonist and immunoconjugates thereof
US-2018126000-A1 · May 10, 2018 · US
US11491237B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11491237-B2 |
| Application number | US-201815975191-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 9, 2018 |
| Priority date | May 18, 2017 |
| Publication date | Nov 8, 2022 |
| Grant date | Nov 8, 2022 |
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Provided herein are compounds, compositions, conjugates and methods for the treatment of diseases, and/or conditions such as, but not limited to, proliferative diseases. In certain embodiments, compounds, compositions, and conjugates are provided, which include cyclodextrin-based linker-payloads and protein conjugates thereof, and/or in combination with other agents. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced.
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What is claimed is: 1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound (i) is according to formula (Ib1), (Ib2), or (Ic1): (ii) is according to a formula selected from:…
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