Apparatus, device and method for capsule microscopy

Patent metadata

Field	Value
Publication number	US-11490797-B2
Application number	US-201313898798-A
Country	US
Kind code	B2
Filing date	May 21, 2013
Priority date	May 21, 2012
Publication date	Nov 8, 2022
Grant date	Nov 8, 2022

Abstract

An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

First claim

What is claimed is:

1. An apparatus for obtaining data regarding at least one portion within at least one luminal or hollow sample, comprising:
a housing substantially enclosing at least one portion of the apparatus;
a fiber first arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion;
a reflective optical element which is configured to forward at least one return radiation from the at least one luminal or hollow sample to an optical microscopy system, wherein an entire outer periphery of the housing is a rigid capsule having a first diameter;
a diffractive optical element which is configured to spectrally disperse different wavelengths of the at least one electromagnetic radiation along different spatial locations in the sample and configured to rotate about an axis that is substantially parallel to a central axis of the housing;
a flexible tether arrangement containing an optical fiber drive shaft coupled to a rotational mechanical arrangement and connected to at least one portion of the entire outer periphery of the housing such that the housing is rotationally immobilized with respect to the flexible tether arrangement, the flexible tether arrangement having a second diameter that is smaller than the first diameter;
wherein the optical fiber drive shaft is structurally connected to the diffractive optical element with the rotational mechanical arrangement configured to rotate the optical fiber drive shaft and the fiber first arrangement within the flexible tether arrangement to cause at least a portion of the reflective optical element and the diffractive optical element to rotate within the rigid capsule to direct an optical axis of the reflective optical element around a circumference of the capsule; and
a video camera disposed within the housing and configured to capture video images.

2. The apparatus according to claim 1 , further comprising an imaging arrangement which generates an image of the at least one portion within the at least one luminal or hollow sample when the reflective optical element is rotated and causes the at least one electromagnetic radiation to radiate with a particular radiation pattern within the at least one luminal or hollow sample.

3. The apparatus according to claim 2 , wherein the flexible tether arrangement and the housing travel along the at least one luminal or hollow sample so as to cause an irradiation with a further radiation pattern, and wherein the imaging arrangement generates the image based on the particular radiation pattern and the further radiation pattern.

4. An apparatus for obtaining data regarding at least one portion within at least one luminal or hollow sample, comprising:
a housing substantially enclosing at least one portion of the apparatus;
a fiber first arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion;
a reflective optical element which is configured to forward at least one return radiation from the at least one luminal or hollow sample to an optical microscopy system, wherein at least one portion of an outer periphery of the housing is a rigid capsule having a first diameter;
a diffractive optical element which is configured to spectrally disperse different wavelengths of the at least one electromagnetic radiation along different spatial locations in the sample and configured to rotate about an axis that is substantially parallel to a central axis of the housing;
a flexible tether arrangement containing an optical fiber drive shaft coupled to a optical rotary joint and connected to the outer periphery of the housing such that the housing is rotationally immobilized with respect to the flexible tether arrangement, the flexible tether arrangement having a second diameter that is smaller than the first diameter;
wherein the optical fiber drive shaft is structurally connected to the diffractive optical element with the optical rotary joint which is configured to rotate the optical fiber drive shaft and the fiber first arrangement within the flexible tether arrangement to cause at least a portion of the reflective optical element and the diffractive optical element to rotate within the rigid capsule to direct an irradiation direction of the at least one electromagnetic radiation around a circumference of the capsule; and
a video camera disposed within the housing and configured to capture video images.

5. The apparatus according to claim 1 , further comprising a grasping arrangement coupled to the flexible tether arrangement which facilitates a grasping of the flexible tether arrangement without compressing the flexible tether arrangement.

6. The apparatus according to claim 1 , further comprising a radiation fiber arrangement which is configured to provide a radiation to the at least one luminal or hollow sample which causes a change thereto.

7. The apparatus according to claim 1 , further comprising an imaging third arrangement which generates a further image of the at least one luminal or hollow sample based on at least one of Optical Coherence Tomography (OCT), Scanning Electro-Chemical Microscopy (SECM), Optical Frequency Domain Imaging (OFDI), confocal, 2 photon, 3 photon, florescence, or Raman modalities.

8. The apparatus according to claim 1 , wherein the fiber first arrangement comprises a ball lens.

9. The apparatus according to claim 1 , further comprising a tether surround configured to prevent damage of the flexible tether arrangement when the flexible tether arrangement is impacted.

10. The apparatus according to claim 1 , wherein the rotational mechanical arrangement includes a structure which is provided at least partially within the flexible tether arrangement.

11. The apparatus according to claim 1 , wherein the video camera is disposed at a distal end of the rigid capsule.

12. The apparatus according to claim 1 , wherein the flexible tether arrangement has a diameter of less than 1 mm and wherein the rigid capsule has a diameter of less than 1 cm.

13. The apparatus according to claim 1 , wherein an inner surface of the flexible tether arrangement is coated with a material comprising polytetrafluoroethylene, and wherein an outer surface of the optical fiber drive shaft is coated with a material comprising polytetrafluoroethylene.

14. The apparatus according to claim 1 , wherein the housing does not include an opening for a guidewire.

15. An apparatus for obtaining data regarding at least one portion within at least one luminal or hollow sample, comprising:
a housing substantially enclosing at least one portion of the apparatus;
a fiber first arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion;
a reflective optical element which is configured to forward at least one return radiation from the at least one luminal or hollow sample to an optical microscopy system, wherein an entire outer periphery of the housing is a rigid capsule having a first diameter;
a diffractive optical element which is configured to spectrally disperse different wavelengths of the at least one electromagnetic radiation along different spatial locations in the sample and configured to rotate about an axis that is substantially parallel to a central axis of the housing;
a flexible tether arrangement containing an optical fiber drive shaft coupled to a rotational mechanical arrangement and connected to at least one portion of the entire outer periphery of the housing such that the housing is rotationally immobilized with respect to the flexible tether arrangement, the flexible tether arra

Assignees

• Massachusetts Gen Hospital

Inventors

• Gora Michalina
• Kang Dongkyun
• Nishioka Norman S
• Bouma Brett Eugene
• Tearney Guillermo J
• Carruth Robert
• Gallagher Kevin
• Sauk Jenny
• Gu Lee Moon
• Tabatabaei Nima
• Shishkov Milen

Classifications

• A61B1/00016

  using wireless means · CPC title

• A61B1/00165

  with light-conductive means, e.g. fibre optics (A61B1/07 takes precedence) · CPC title

• A61B5/0066

  Optical coherence imaging · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B1/00032

  internally powered · CPC title