Intelligent medication delivery systems and methods

Patent metadata

Field	Value
Publication number	US-11484657-B2
Application number	US-201816004275-A
Country	US
Kind code	B2
Filing date	Jun 8, 2018
Priority date	Jun 9, 2017
Publication date	Nov 1, 2022
Grant date	Nov 1, 2022

Abstract

Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a system includes an injection pen device including a dose setting mechanism, a dispensing mechanism, and an electronics unit to generate dose data associated with a dispensing event of a dose of the medicine dispensed from the injection pen device and time data associated with the dispensing event; a mobile device in wireless communication to receive and process the dose data; and a software application configured to determine a recommended dose based on health data and contextual data associated with a user of the injection pen device, the software application including a learning dose calculator module to adaptively calculate the recommended dose of the medicine based on time-relevant and circumstances-relevant data specific to the user of the injection pen device.

First claim

What is claimed is:

1. A system for administering a medicine to a patient, comprising:
an injection pen device including a dose setting mechanism to set a dose of a medicine contained in a medicine cartridge that is to be dispensed by the injection pen device, a dispensing mechanism to dispense the medicine according to the set dose, and electronic circuits including a processor, a memory storing instructions executable by the processor, and a wireless transmitter, the processor of the injection pen device configured to generate dose data associated with a dispensing event of a dose of the medicine dispensed from the injection pen device and time data associated with the dispensing event, and to wirelessly transmit the dose data;
a mobile communication device in wireless communication with the injection pen device, the mobile communication device including a data processing unit including a processor and a memory to receive and process the dose data, wherein the mobile communication device includes a non-transitory computer-readable storage medium having instructions, which when executed by the processor of the data processing unit, cause the mobile communication device to determine a recommended dose based on health data and contextual data associated with a user of the injection pen device, the contextual data including one or more of physical activity data, location data, or nutrient data corresponding to a food,
wherein the memory of the mobile communication device stores a data aggregator that obtains the health data and the contextual data, and a learning dose calculator that calculates the recommended dose of the medicine, wherein dose calculations by the learning dose calculator are adapted in accordance with data associated with time, location, activity, and food at a particular time and specific to the user of the injection pen device; and
an encoder disposed within the injection pen device and in communication with the processor of the injection pen device, the encoder configured to generate an analog output signal in response to movement of the dispensing mechanism to dispense the medicine, wherein at least one of the memory of the injection pen device or the memory of the mobile communication device stores a digital noise filter module configured to apply an algorithm that forces at least one edge of the analog output signal of the encoder to conform to a pattern consistent with a forward direction of movement to determine a quantity of the dose of the medicine dispensed from the injection pen device.

2. The system of claim 1 , wherein the instructions, when executed by the processor of the data processing unit, cause the mobile communication device to:
receive one or more analyte values associated with a health condition of the user to which the medicine is associated;
receive the health data and the contextual data associated with the user;
determine a set of dose calculator parameter settings specific to a current health state of the user;
calculate a medicine dose value using the set of dose calculator parameter settings; and
generate at least one of a displayable output or actuatable output based on the calculated medicine dose value.

3. The system of claim 2 , wherein the instructions, when executed by the processor of the data processing unit, cause the mobile communication device to:
produce a learned set of dose calculator parameter settings by processing (i) a physiological response of the user to an injection of the medicine into the user at a dose dispensed according to the medicine dose value with (ii) a past set of dose calculator parameter settings and (iii) the one or more analyte values and the health data and the contextual data that correspond to the set of dose calculator parameter settings determined for the calculated medicine dose value corresponding to the injection of the medicine into the user; and
store the learned set of dose calculator parameter settings by one or both of (i) modifying one or more existing dose calculator parameter settings and (ii) adding one or more new dose calculator parameter settings.

4. The system of claim 3 , wherein the instructions, when executed by the processor of the data processing unit, cause the mobile communication device to generate a quantitative score associated with the physiological response of the user including time data associated with a resultant analyte level and degree to which the resultant analyte level is within a target analyte level range.

5. The system of claim 2 , wherein the received one or more analyte values and/or the received health data and contextual data are imported from a software application operable on the mobile communication device.

6. The system of claim 2 , wherein the displayable output includes the recommended dose and is configured to be displayed on one or both of the mobile communication device and the injection pen device.

7. The system of claim 2 , wherein the actuatable output includes executable code to cause the injection pen device to actuate an operation including one or more of automatically setting, at the dose setting mechanism, the dose of the medicine to the calculated medicine dose value; or generating an alert indicative of a medicine dispensing event at the calculated medicine dose value.

8. The system of claim 1 , wherein the instructions, when executed by the processor of the data processing unit, cause the mobile communication device to update the recommended dose of the medicine on one of a periodic basis, a continuous basis, or an intermittent basis.

9. The system of claim 1 , wherein the memory of the mobile communication device stores a food identification module to process the contextual data associated with a food to eat or eaten by the user of the injection pen device and additional data including at least one of a food history, a location of the user, or a time of day to produce a data set that is processable by the learning dose calculator to calculate the recommended dose.

10. The system of claim 9 , wherein the instructions, when executed by the processor of the data processing unit, cause the mobile communication device to produce a food data parameter for dose calculation including meal nutritional content associated with the food to eat or eaten by the user, by:
identifying information associated with a food item from an image of the food item and based on a current time and day and a current location, wherein the identified information associated with the food item includes a type of the food item and an estimated amount of carbohydrates in the food item;
estimating a probability of food items based on the current time and day and the current location in conjunction with personal food history data specific to the user; and
generating the food data parameter using at least one of the identified information associated with the food item or the estimated probability of food items.

11. The system of claim 10 , wherein the identifying the information associated with the food item includes executing image recognition processing of the food item image based on the current time and day and the current location in conjunction with food history data.

12. The system of claim 10 , wherein the food history data is specific to the user and includes a frequency of food items consumed at a location or locations proximate to the current location and at a time or times proximate to the current time and day.

13. The system of claim 10 , wherein the food history data includes crowdsourced food history data obtained from other individuals, wherein the crowdsourced food history data is stored in a cloud database accessible by the mo

Assignees

• Companion Medical Inc
• Medtronic Minimed Inc

Inventors

• Saint Sean
• Mensinger Mike
• Holmquist Arnold
• Pryor Jack

Classifications

• A61M2205/50

  with microprocessors or computers · CPC title

• A61M2005/3126

  Specific display means related to dosing · CPC title

• A61M2230/201

  Glucose concentration · CPC title

• A61M5/31535

  Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose · CPC title

• G01D5/24461

  by redundancy or plausibility · CPC title