Sealing systems for a reservoir of an on-body injector

Patent metadata

Field	Value
Publication number	US-11484646-B1
Application number	US-202117307594-A
Country	US
Kind code	B1
Filing date	May 4, 2021
Priority date	May 4, 2021
Publication date	Nov 1, 2022
Grant date	Nov 1, 2022

Abstract

An on-body injector includes a drug reservoir having an outlet. First and second pistons may be positioned within the reservoir, with the second piston first being moved to open the outlet, followed by the first piston being moved to convey a drug from the reservoir via the outlet. The reservoir may instead include a cover, with a valve positioned between the outlet and the cover. The valve is rotated to place a channel of the valve in fluid communication with a through-hole of the cover, allowing flow from the reservoir via the outlet. The reservoir may instead include a valve movable from a condition in which it deforms the outlet, preventing flow through the outlet, to a condition allowing flow. The reservoir may instead include a seal that is deformed by an increase in pressure within the reservoir, with the deformed seal being open to allow flow through the outlet.

First claim

The invention claimed is:

1. An on-body injector comprising:
a housing;
an adhesive pad associated with a lower surface of the housing and configured to be removably attached to a human body surface;
a drug reservoir positioned within the housing and including
an elongated and generally tubular outlet having an end fixedly secured with respect to the drug reservoir, and
a seal at least partially positioned within the drug reservoir and secured between the outlet and at least a portion of the drug reservoir;

a needle fluidically connected to the outlet of the drug reservoir; and
a controller configured to control the components of the on-body injector to execute a drug delivery routine, wherein
the seal is configured to be deformed from a first condition to a second condition by an increase in pressure within the drug reservoir,
the seal prevents fluid flow from the drug reservoir via the outlet in the first condition, and
the seal is at least partially open in the second condition so as to allow fluid flow from the drug reservoir via the outlet.

2. The on-body injector of claim 1 , wherein the seal is configured as a film.

3. The on-body injector of claim 2 , wherein
the seal includes at least one weakened section configured to be broken upon an increase in pressure within the drug reservoir, and
said at least one weakened section of the seal is unbroken in the first condition and broken in the second condition.

4. The on-body injector of claim 3 , wherein the weakened section is configured as a scored section of the seal.

5. The on-body injector of claim 3 , wherein the weakened section is configured as a perforated section of the seal.

6. The on-body injector of claim 3 , wherein the weakened section is configured as a creased section of the seal.

7. The on-body injector of claim 3 , wherein the weakened section has a thickness that is less than a thickness of other sections of the seal.

8. The on-body injector of claim 2 , further comprising a piercing element at least partially positioned within the drug reservoir, wherein
the seal is spaced away from the piercing element in the first condition, and
the piercing element engages the seal in the second condition to pierce and at least partially open the seal.

9. The on-body injector of claim 8 , wherein
the piercing element defines a lumen fluidically connected to the outlet of the drug reservoir, and
the lumen is configured to direct fluid flow from an interior of the drug reservoir to the outlet when the seal is in the second condition.

10. The on-body injector of claim 1 , wherein the seal is at least partially formed of an elastomeric material.

11. The on-body injector of claim 10 , wherein the seal is configured as a check valve having an end configured to be closed in the first condition and open in the second condition.

12. The on-body injector of claim 1 , further comprising a piston at least partially positioned within the drug reservoir, wherein the piston is configured to be moved toward the seal to increase the pressure in the drug reservoir.

13. The on-body injector of claim 1 , wherein the controller is configured to execute a drug delivery routine for a drug comprising pegfilgrastim.

14. The on-body injector of claim 1 , wherein the seal is configured to not be capable of returning to the first condition from the second condition.

15. The on-body injector of claim 1 , wherein the seal is configured to be capable of returning to the first condition from the second condition.

16. The on-body injector of claim 1 , wherein the controller is configured to control the components of the on-body injector to continuously convey a drug from the drug reservoir during the drug delivery routine.

17. The on-body injector of claim 1 , wherein the controller is configured to control the components of the on-body injector to intermittently convey a drug from the drug reservoir during the drug delivery routine.

18. The on-body injector of claim 1 , wherein the seal is at least partially formed of a metallic material.

19. The on-body injector of claim 1 , wherein the seal is configured as a duckbill valve having an end configured to be closed in the first condition and open in the second condition.

20. The on-body injector of claim 1 , wherein the seal is configured as a poppet valve having an end configured to be closed in the first condition and open in the second condition.

21. An on-body injector comprising:
a housing;
an adhesive pad associated with a lower surface of the housing and configured to be removably attached to a human body surface;
a drug reservoir positioned within the housing and including
an elongated and generally tubular outlet having an end configured to remain stationary with respect to the drug reservoir, and
a seal at least partially positioned within the drug reservoir and secured between the outlet and at least a portion of the drug reservoir;

a needle fluidically connected to the outlet of the drug reservoir; and
a controller configured to control the components of the on-body injector to execute a drug delivery routine, wherein
the seal is configured to be deformed from a first condition to a second condition by an increase in pressure within the drug reservoir,
the seal prevents fluid flow from the drug reservoir via the outlet in the first condition, and
the seal is at least partially open in the second condition so as to allow fluid flow from the drug reservoir via the outlet.

22. An on-body injector comprising:
a housing;
an adhesive pad associated with a lower surface of the housing and configured to be removably attached to a human body surface;
a drug reservoir positioned within the housing and including
an elongated and generally tubular outlet having an end secured with respect to the drug reservoir, and
a seal at least partially positioned within the drug reservoir and secured between the outlet and at least a portion of the drug reservoir;

a needle fluidically connected to the outlet of the drug reservoir; and
a controller configured to control the components of the on-body injector to execute a drug delivery routine, wherein
the seal is configured to be deformed from a first condition to a second condition by an increase in pressure within the drug reservoir,
the seal prevents fluid flow from the drug reservoir via the outlet in the first condition, and
the seal is at least partially open in the second condition so as to allow fluid flow from the drug reservoir via the outlet.

Assignees

• Fresenius Kabi Deutschland Gmbh

Inventors

• Schiff David R
• West Sharon D
• Zerweck Jason

Classifications

• A61M2005/14252

  with needle insertion means · CPC title

• A61M5/14248 Primary

  of the skin patch type · CPC title

• A61M5/16881

  Regulating valves (on-off valves, e.g. clamps A61M39/28) · CPC title

• A61M5/1454 Primary

  spring-actuated, e.g. by a clockwork · CPC title