Targeting cell tropism receptors to inhibit cytomegalovirus infection

US11484570B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11484570-B2
Application numberUS-201816604735-A
CountryUS
Kind codeB2
Filing dateApr 13, 2018
Priority dateApr 14, 2017
Publication dateNov 1, 2022
Grant dateNov 1, 2022

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Methods for treating or reducing the risk of a cytomegalovirus infection in a subject that include administering one or more of an inhibitor of Deleted in Malignant Brain Tumors 1 (DMBT1), an inhibitor of OR14I1, or an inhibitor of adenylyl cyclases.

First claim

Opening claim text (preview).

What is claimed is: 1. A method of treating or reducing the risk of a cytomegalovirus (CMV) infection in a mammalian subject, the method comprising administering to the subject a therapeutically effective amount of one or more of an inhibitor of Olfactory Receptor Family 14 Subfamily I Member 1 (OR14I1), wherein the inhibitor of OR14I1 is an N-terminal peptide of OR14I1 comprising the amino acid sequence MDNLTKVTEFLLMEFSGIWELQVLHA (SEQ ID NO:1), or an active fragment thereof. 2. The method of claim 1 , wherein the active fragment comprises FLLMEFSGIWELQ (SEQ ID NO:3), LLMEFSGIWELQV (SEQ ID NO:4), LMEFSGIWELQVL (SEQ ID NO:5), or LMEFSGIWELQ (SEQ ID NO:6).

Assignees

Inventors

Classifications

  • against receptors, cell surface antigens or cell surface determinants · CPC title

  • comprising antibodies · CPC title

  • Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title

  • interfering nucleic acids [NA] · CPC title

  • A61K38/177Primary

    Receptors; Cell surface antigens; Cell surface determinants · CPC title

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Frequently asked questions

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What does patent US11484570B2 cover?
Methods for treating or reducing the risk of a cytomegalovirus infection in a subject that include administering one or more of an inhibitor of Deleted in Malignant Brain Tumors 1 (DMBT1), an inhibitor of OR14I1, or an inhibitor of adenylyl cyclases.
Who is the assignee on this patent?
Univ Massachusetts
What technology area does this patent fall under?
Primary CPC classification A61K38/177. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).