Biological signal analysis device, biological signal measurement system, and computer-readable medium

Patent metadata

Field	Value
Publication number	US-11484268-B2
Application number	US-201916292480-A
Country	US
Kind code	B2
Filing date	Mar 5, 2019
Priority date	Mar 15, 2018
Publication date	Nov 1, 2022
Grant date	Nov 1, 2022

Abstract

A biological signal analysis device includes: an acquiring unit configured to acquire biological signals of a measurement target; a trigger information acquiring unit configured to acquire, from a stimulator configured to apply stimuli to the measurement target, trigger information indicating times at which the stimuli are generated; and a signal processing unit configured to process the biological signals. The signal processing unit is configured to calculate biological information on the measurement target based on the biological signals, maintain only pieces of trigger information corresponding to times at which it is determined that biological signals of the measurement target are generated, from the calculated biological information, delete another piece of trigger information, and use an averaged waveform that is obtained by performing an averaging process on the biological signals that are generated in synchronization with the stimuli based on the pieces of remaining trigger information.

First claim

What is claimed is:

1. A biological signal analysis device comprising:
memory having computer readable instructions stored thereon; and
processing circuitry configured to execute the computer readable instructions to cause the biological signal analysis device to,
acquire a plurality of biological signals of a measurement target from a biological signal measurement device configured to measure the plurality of biological signals;
acquire, from a stimulator device configured to apply stimuli to the measurement target, trigger information indicating times at which the stimuli are generated; and
process the plurality of biological signals, the processing the plurality of biological signals including,
calculating biological information on the measurement target based on the plurality of biological signals,
maintaining first pieces of the trigger information corresponding to times at which the plurality of biological signals correspond to an awake state of the measurement target, from the calculated biological information,
deleting second pieces of trigger information corresponding to times at which the plurality of biological signals correspond to a sleep state of the measurement target, and
generating an averaged waveform by performing an averaging process on the plurality of biological signals corresponding to the awake state in synchronization with the stimuli based on the first pieces of trigger information.

2. The biological signal analysis device according to claim 1 , wherein the processing circuitry is further configured to cause the biological signal analysis device to:
perform frequency analysis on the plurality of biological signals of the awake state.

3. The biological signal analysis device according to claim 2 , wherein
the sleep state corresponds to at least one of a plurality of sleep states, the plurality of sleep states including a light sleep state, a slow-wave sleep state, a deep sleep state, and a REM sleep state; and
the processing circuitry is further configured to cause the biological signal analysis device to delete the second pieces of trigger information included in a time corresponding to the sleep state of the measurement target.

4. The biological signal analysis device according to claim 1 , wherein the processing circuitry is further configured to cause the biological signal analysis device to:
control display of a screen based on a result of frequency analysis performed on the plurality of biological signals.

5. The biological signal analysis device according to claim 4 , wherein the processing circuitry is further configured to cause the biological signal analysis device to change a display color of a region of the screen determined to correspond to a sleep state as a result of the frequency analysis performed on the plurality of biological signals, to a darker color than a color of another region of the screen.

6. A biological signal measurement system comprising:
a biological signal measurement device configured to measure a plurality of biological signals of a measurement target; and
a biological signal analysis device configured to,
acquire a plurality of biological signals of the measurement target from the biological signal measurement device;
acquire, from a stimulator device configured to apply stimuli to the measurement target, trigger information indicating times at which the stimuli are generated; and
process the plurality of biological signals, the processing the plurality of biological signals including,
calculating biological information on the measurement target based on the plurality of biological signals,
maintaining first pieces of the trigger information corresponding to times at which the plurality of biological signals correspond to an awake state of the measurement target, from the calculated biological information,
deleting second pieces of trigger information corresponding to times at which the plurality of biological signals correspond to a sleep state of the measurement target, and
generating an averaged waveform by performing an averaging process on the plurality of biological signals corresponding to the awake state in synchronization with the stimuli based on the first pieces of trigger information.

7. A non-transitory computer-readable medium including programmed instructions, which when executed by processing circuitry of a computer, cause the computer to:
acquire, from a stimulator device configured to apply stimuli to a measurement target, trigger information indicating times at which the stimuli are generated; and
process a plurality of biological signals of the measurement target, the processing the plurality of biological signals including,
calculating biological information on the measurement target based on the plurality of biological signals,
maintaining first pieces of the trigger information corresponding to times at which the plurality of biological signals correspond to an awake state of the measurement target, from the calculated biological information,
deleting second pieces of trigger information corresponding to times at which the plurality of biological signals correspond to a sleep state of the measurement target, and
generating an averaged waveform by performing an averaging process on the plurality of biological signals corresponding to the awake state in synchronization with the stimuli based on the first pieces of trigger information.

8. The non-transitory computer-readable medium according to claim 7 , wherein the awake state corresponds to at least one of a wakefulness state, and a relaxed wakefulness state.

9. The biological signal analysis device according to claim 1 , wherein the awake state corresponds to at least one of wakefulness state, and a relaxed wakefulness state.

10. The biological signal analysis device according to claim 1 , wherein the processing circuitry is further configured to cause the biological signal analysis device to:
detect whether the measurement target is in the sleep state based on the plurality of biological signals.

11. The biological signal analysis device according to claim 1 , wherein the processing circuitry is further configured to cause the biological signal analysis device to:
generate a dipole estimation of the plurality of biological signals of the awake state in synchronization with the stimuli based on the first pieces of trigger information.

12. The biological signal analysis device according to claim 1 , wherein the stimuli applied to the measurement target is visual stimuli.

13. The non-transitory computer-readable medium of claim 7 , wherein the computer is further caused to:
perform frequency analysis on the plurality of biological signals of the awake state.

14. The non-transitory computer-readable medium of claim 7 , wherein
the sleep state corresponds to at least one of a plurality of sleep states, the plurality of sleep states including a light sleep state, slow-wave sleep state, a deep sleep state, and a REM sleep state; and
the computer is further caused to,
delete the second pieces of trigger information included in a time corresponding to the sleep state of the measurement target.

15. The non-transitory computer-readable medium of claim 7 , wherein the computer is further caused to:
control display of a screen based on a result of frequency analysis performed on the plurality of biological signals.

16. The non-transitory computer-readable medium of claim 15 , wherein the computer is further caused to:
change a display color of a region of the screen determined to correspond to a sleep state as a result of

Assignees

• Yamagata Hideaki
• Okumura Eiichi
• Tomita Noriyuki
• Ricoh Co Ltd

Inventors

• Yamagata Hideaki
• Okumura Eiichi
• Tomita Noriyuki

Classifications

• A61B5/4812

  Detecting sleep stages or cycles · CPC title

• A61B5/7425

  Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image · CPC title

• A61B5/377

  using evoked responses · CPC title

• A61B5/7285

  for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal · CPC title

• A61B5/246

  using evoked responses · CPC title