Systems and methods for delivering focalized neurostimulation

Patent metadata

Field	Value
Publication number	US-11478639-B2
Application number	US-202217592646-A
Country	US
Kind code	B2
Filing date	Feb 4, 2022
Priority date	Feb 12, 2021
Publication date	Oct 25, 2022
Grant date	Oct 25, 2022

Abstract

Systems and methods for delivering targeted neurostimulation therapies to the nervous system of a subject are provided. A set of electrodes can be strategically distributed around a target nerve, and the nerve can be activated though the electrodes using a channel-hopping interleaved pulse scheduling (CHIPS) stimulation strategy. The systems and methods can leverage the spatiotemporal summation of short, sub-threshold current pulses interleaved across two or more independent stimulation channels (hopping from channel to channel) and delivered across electrodes strategically placed in an interfering configuration around the target neural tissue.

First claim

What is claimed is:

1. A system for delivering targeted focal neurostimulation with reduced charge density and increased selectivity to a target nerve, the system comprising:
a first channel comprising a first alternating current (AC) source connected to a first stimulating electrode and a first receiving electrode, the first stimulating electrode radially spaced from the target nerve, and the first receiving electrode being in opposition to the first stimulating electrode such that a first signal path defined therebetween stimulates the target nerve;
a second channel comprising a second AC source connected to a second stimulating electrode and a second receiving electrode, the second stimulating electrode radially spaced from the target nerve, and the second receiving electrode being in opposition to the second stimulating electrode such that a second signal path defined therebetween crosses the first signal path and stimulates the target nerve;
a processor in operable communication with the first channel and the second channel; and
a machine-readable medium in operable communication with the processor and having instructions stored thereon that, when executed by the processor, perform the following steps:
delivering through the first channel a first stimulation pulse (SP1) having a first stimulation pulse width (SP1W);
delivering through the second channel a second stimulation pulse (SP2) after delivery of the SP1, the SP2 having a second stimulation pulse width (SP2W), the SP1 and the SP2 each contributing to an effective net stimulation pulse (ESP) having an effective net stimulation pulse width (ESPW) sufficient to effectively stimulate the target nerve, the ESPW being greater than the SP1W and the ESPW being greater than the SP2W, thereby delivering the targeted focal neurostimulation with reduced charge density and increased selectivity to the target nerve;
delivering through one of the first channel or the second channel a first charge-balancing pulse (BP1) after delivery of the SP2, the BP1 having a first balancing pulse width (BP1W); and
delivering through the other of the first channel or the second channel a second charge-balancing pulse (BP2) after delivery of the BP1, the BP2 having a second balancing pulse width (BP2W), the BP1 and the BP2 each contributing to an effective net charge-balancing pulse (EBP) having an effective net charge-balancing pulse width (EBPW) sufficient to effectively reduce a residual local charge created by the ESP in or around the target nerve, the EBPW being greater than the BP1 W and the EBPW being greater than the BP2W.

2. The system according to claim 1 , each of the SP1, the SP2, the BP1, and the BP2, respectively, having a start time and an end time, and the start time of the BP1 being followed by an inter-phase gap (IPG) having a value between 0 microseconds and 500 microseconds after the end time of the SP2.

3. The system according to claim 2 , the start time of the SP2 being followed by a first interleaved stimulation pulse delay (DS1) having a value between 0 microseconds and 500 microseconds after the end time of either (a) the SP1, or (b) an optional additional interleaved stimulation pulse (SP3), the SP3, if present, being delivered after delivery of the SP1, and before the delivery of the SP2.

4. The system according to claim 2 , the start time of the BP2 being followed by a first interleaved charge-balancing pulse delay (DB1) having a value between 0 microseconds and 500 microseconds after the end time of either (a) the BP1, or (b) an optional additional interleaved charge-balancing pulse (BP3), the BP3, if present, being delivered after delivery of the BP1, and before the delivery of the BP2.

5. The system according to claim 1 , the instructions when executed further performing the following additional steps:
delivering through one of the first channel or the second channel a fourth stimulation pulse (SP4) after delivery of the BP2, the SP4 having a fourth stimulation pulse width (SP4W); and
delivering through the other of the first channel or the second channel a fifth stimulation pulse (SP5) after delivery of the SP4, the SP5 having a fifth stimulation pulse width (SP5W), the SP4 and the SP5 each contributing to a second effective net stimulation pulse (ESP2) having a second effective net stimulation pulse width (ESP2W) sufficient to effectively stimulate the target nerve, the ESP2W being greater than the SP4W and the ESP2W being greater than the SP5W.

6. The system according to claim 5 , each of the SP4 and the SP5, respectively, having a start time and an end time, the start time of the SP5 being followed by a second interleaved stimulation pulse delay (DS2) having a value between 0 microseconds and 500 microseconds after the end time of either (a) the SP4, or (b) an optional additional interleaved stimulation pulse (SP6), the SP6, if present, being delivered after delivery of the SP4, and before the delivery of the SP5.

7. The system according to claim 1 , the first stimulating electrode and the first receiving electrode being positioned to stimulate the target nerve transversely.

8. The system according to claim 1 , the second stimulating electrode and the second receiving electrode being positioned to stimulate the target nerve transversely and being generally aligned longitudinally with each other and with the first stimulating electrode and the first receiving electrode.

9. The system according to claim 1 , the SP1 and the BP1 forming an anode-first biphasic pulse on the first channel, the SP2 and the BP2 forming an anode-first biphasic pulse on the second channel, and the SP1, the SP2, the BP1, and the BP2 each contributing to delivering an effective anode-first biphasic pulse to the target nerve.

10. A method for delivering targeted focal neurostimulation with reduced charge density and increased selectivity to a target nerve, the method comprising:
providing a first channel comprising a first alternating current (AC) source connected to a first stimulating electrode and a first receiving electrode, the first stimulating electrode radially spaced from the target nerve, and the first receiving electrode being in opposition to the first stimulating electrode such that a first signal path defined therebetween stimulates the target nerve;
providing a second channel comprising a second AC source connected to a second stimulating electrode and a second receiving electrode, the second stimulating electrode radially spaced from the target nerve, and the second receiving electrode being in opposition to the second stimulating electrode such that a second signal path defined therebetween crosses the first signal path and stimulates the target nerve;
delivering through the first channel a first stimulation pulse (SP1) having a leading stimulation pulse width (SP1W);
delivering through the second channel a second stimulation pulse (SP2) after delivery of the SP1, the SP2 having a trailing stimulation pulse width (SP2W), the SP1 and the SP2 each contributing to an effective net stimulation pulse (ESP) having an effective net stimulation pulse width (ESPW) sufficient to effectively stimulate the target nerve, the ESPW being greater than the SP1W and the ESPW being greater than the SP2W, thereby delivering the targeted focal neurostimulation with reduced charge density and increased selectivity to the target nerve;
delivering through one of the first channel or the second channel a first charge-balancing pulse (BP1) after delivery of the SP2, the BP1 having a first balancing pulse width (BP1W); and
delivering through the other of the first channel or the second channel a second charge-balancing pulse (BP2) after delivery of the BP1, the BP2 having a second balancing

Assignees

• Pena Serrada Andres E
• Jung Ranu
• Abbas James
• Horch Kenneth
• The Florida International Univ Board Of Trustees
• Univ Arizona State

Inventors

• Pena Serrada Andres E
• Jung Ranu
• Abbas James
• Horch Kenneth

Classifications

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• G16H40/67

  for remote operation · CPC title

• G16H10/20

  for electronic clinical trials or questionnaires · CPC title

• G16H40/63

  for local operation · CPC title

• G16H20/30

  relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising · CPC title