Method and system for optimisation of DBS programming

Patent metadata

Field	Value
Publication number	US-11478633-B2
Application number	US-201716085954-A
Country	US
Kind code	B2
Filing date	Mar 15, 2017
Priority date	Mar 15, 2016
Publication date	Oct 25, 2022
Grant date	Oct 25, 2022

Abstract

A method and system are described for, based upon a plurality of previously-acquired directional LFP signals measured in a plurality of different directions at a directional sensor lead located in a predetermined region of a patient's brain, determining optimised patient-specific programming parameters for programming a directional stimulation lead with parameters for stimulating the said region. The method comprises a first step of determining, over at least one predetermined frequency range, a power-frequency variation curve of each of the directional LFP signals, a second step of identifying frequency peaks in the power-frequency variation curves, a third step of detecting one of the identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs, and a fourth step of calculating a plurality of directional stimulation weighting factors on the basis of the relative signal powers of the directional LFP signals at the detected frequency peak.

First claim

I claim:

1. A method comprising using at least one hardware processor for determining patient-specific optimized programming parameters to facilitate programming a directional multi-electrode stimulation lead with parameters for stimulating a region based upon a plurality of directional local field potential (“LFP”) signals measured in a plurality of different directions by a sensor located in a predetermined region of a patient's brain, said processor configured to: determine, over at least one predetermined frequency ranges, a power-frequency variation curve for each directional LFP signal recorded from the at least one sensor of at least one deep brain stimulation (“DBS”) lead; identify, through a spectral analysis calculation, at least one frequency peak in said power-frequency variation curve; detect one of said at least one identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs; calculate a plurality of directionally weighted stimulation indices for the directional multi-electrode stimulation lead on the basis of the relative signal powers of the directional LFP signals at the frequency of the detected frequency peak; and automatically selecting an electrode configuration on the directional multi-electrodes stimulation lead connected to an implanted pulse generator to facilitate optimization of a subsequent DBS regime.

2. The method of claim 1 , wherein the frequency range comprises a beta frequency range.

3. The method of claim 1 , wherein determining the power-frequency variation curve comprises determining power-frequency curves for a plurality of frequency ranges, the frequency ranges being usable alone or in combination to guide stimulation.

4. The method of claim 1 , wherein calculating the plurality of directionally weighted stimulation indices comprises:
selecting a directionality indicating frequency range (“DIFR”) based on the detected frequency peak; and
determining a directionality index (“DI”) for each electrode of a plurality of electrodes of said directional stimulation lead and for each montage of the plurality of montages of said electrodes of said directional stimulation lead.

5. The method of claim 4 , wherein said DIFR is a predetermined constant frequency range centered on the frequency of the detected frequency peak, wherein the width of said DIFR is selected in dependence on the frequency of said detected frequency peak.

6. The method of claim 4 , wherein determining the directionality index comprises normalizing a baseline correction of an average amplitude of each of said power-frequency variation curves in said DIFR.

7. The method of claim 6 , wherein said baseline correction comprises subtracting a predetermined proportion of the average amplitude from an amplitude of each of the curves.

8. The method of claim 7 , further comprising summing an average amplitude of each curve over said DIFR to give a proportional distribution for each direction associated with each of the curves.

9. A system comprising at least one hardware processor configured to determine optimized patient-specific electrode configuration to facilitate programming of a directional multi-electrode stimulation lead, having a directional sensor and stimulation electrodes, for stimulating a predetermined region of a patient's brain, said processor configured to receive a plurality of previously-acquired directional LFP signals measured in a plurality of different directions by the directional sensor lead configured to be located in the predetermined region of the patient's brain; determine, through a spectral analysis calculation, over at least one predetermined frequency range, a power-frequency variation curve for each of the directional LFP signals; identify, through peak detection, at least one frequency peak in the power-frequency variation curves determined by the spectral analysis calculation means; detecting one of the at least one identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs; calculate, through a directionality determination, a plurality of directionally weighted stimulation parameters for the directional stimulation lead on the basis of relative signal powers of the directional UP signals at a frequency of the detected frequency peak; and automatically configure an electrode combination on the directional multi-electrodes stimulation lead connected to an implanted pulse generator to facilitate optimization of a subsequent DBS regime.

10. The system of claim 9 , further comprising an implantable pulse generator device, wherein at least one of the spectral analysis calculations, peak detection, difference detection, and directionality determination are integrated into the pulse generator device for driving the directional multi-electrodes stimulation lead.

11. The system of claim 9 , further comprising a directional multi-electrodes stimulation lead configured to perform directional stimulation according to directionally weighted stimulation parameters provided by said processor.

12. The system of claim 9 , further comprising a programmable implantable pulse generator device for driving said directional multi-electrodes stimulation lead, wherein the said programmable implantable pulse generator device for is configured to acquire and record LFP signal data from said sensor lead.

13. A computer program product for determining optimized patient-specific programming parameters to facilitate programming a directional multi-electrode stimulation lead with parameters for stimulating the region based upon a plurality of directional low field potential (“LFP”) signals measured in a plurality of different directions at a directional sensor configured to be located in a predetermined region of a patient's brain, the computer program product comprising a non-transitory computer-readable storage medium having program code embodied therewith, the program code executable by at least one hardware processor to: determine, over at least one predetermined frequency range, a power-frequency variation curve for each directional LFP signal of the directional LFP signals recorded from directional multi-electrodes stimulation lead; identify, through a spectral analysis calculation, at least one frequency peak in the said power-frequency variation curves; detect one of said at least one identified frequency peaks at which a maximum difference in signal power between the directional ITP signals occurs: calculate a plurality of directionally weighted stimulation indices for the directional stimulation lead on the basis of relative signal power of the directional LFP signals at the frequency of the detected frequency peak: and automatically selecting an electrode configuration on the directional multi-electrodes stimulation lead connected to an implanted pulse generator to facilitate optimization of a subsequent DBS regime.

Assignees

• Univ Bern

Inventors

• Tinkhauser Gerd
• Brown Peter
• Pogosyan Alek
• Schüpbach Michael
• Pollo Claudio
• Debove Ines

Classifications

• A61N1/36135

  using physiological parameters · CPC title

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/0031

  Implanted circuitry · CPC title

• A61N1/0534 Primary

  Electrodes for deep brain stimulation · CPC title

• A61N1/36067

  Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003) · CPC title