Biodegradable hydrogel and methods for use thereof

Patent metadata

Field	Value
Publication number	US-11478550-B2
Application number	US-201816198556-A
Country	US
Kind code	B2
Filing date	Nov 21, 2018
Priority date	Nov 21, 2018
Publication date	Oct 25, 2022
Grant date	Oct 25, 2022

Abstract

The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.

First claim

What is claimed is:

1. A hydrogel composition comprising:
a first ABA triblock copolymer having negatively charged A blocks, wherein the first ABA triblock copolymer is a phenylboronic acid-functionalized polycarbonate/poly(ethylene glycol) (PEG) ABA triblock copolymer; and
a second ABA triblock copolymer having positively charged A blocks.

2. The hydrogel composition of claim 1 , wherein the first ABA triblock copolymer has the structure of formula I:

wherein m is between 1 and 10 and PEG 10K is 10 kDa poly(ethylene glycol).

3. The hydrogel composition of claim 2 , wherein m is 5.

4. The hydrogel composition of claim 1 , wherein the second ABA triblock copolymer includes A blocks containing either guanidine or thiouronium.

5. The hydrogel composition of claim 4 , wherein the second ABA triblock copolymer has the structure of formula II:

wherein x is between 1 and 10, n is 227, and TFA is trifluoroacetic acid.

6. The hydrogel composition of claim 5 , wherein x is 5.

7. The hydrogel composition of claim 4 , wherein the second ABA triblock copolymer has the structure of formula III:

wherein m is between 1 and 10 and n is 227.

8. The hydrogel composition of claim 7 , wherein m is 5.

9. A micellar particle comprising:
a hydrogel composition comprising:
a first ABA triblock copolymer having negatively charged A blocks, wherein the first ABA triblock copolymer is a phenylboronic acid-functionalized polycarbonate/poly(ethylene glycol) (PEG) ABA triblock copolymer; and
a second ABA triblock copolymer having positively charged A blocks; and
at least one agent for delivery within the hydrogel composition.

10. The micellar particle of claim 9 , wherein:
the first ABA triblock copolymer is a phenylboronic acid-functionalized polycarbonate/poly(ethylene glycol) (PEG) ABA triblock copolymer has the structure of formula I:

wherein m is between 1 and 10 and PEG 10K is 10 kDa poly(ethylene glycol); and
the second ABA triblock copolymer has the structure of formula II or the structure of formula III:

wherein x is between 1 and 10, n is 227, and TFA is trifluoroacetic acid,

wherein m is between 1 and 10 and n is 227.

Assignees

• IBM
• Inst Of Bioengineering And Nanotechnology

Inventors

• Fevre Mareva B
• Hedrick James L
• Lee Ashlynn
• Park Nathaniel H
• Wojtecki Rudy J
• Yang Yi Yan
• Voo Zhi Xiang

Classifications

• C08L2203/02

  for biomedical use · CPC title

• C08L69/00

  Compositions of polycarbonates; Compositions of derivatives of polycarbonates · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• C08L2205/025

  containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure · CPC title

• B01J13/0052

  Preparation of gels · CPC title