Delivering tumor treating fields (TTFields) using implantable transducer arrays

Patent metadata

Field	Value
Publication number	US-11471676-B2
Application number	US-202016801972-A
Country	US
Kind code	B2
Filing date	Feb 26, 2020
Priority date	Feb 27, 2019
Publication date	Oct 18, 2022
Grant date	Oct 18, 2022

Abstract

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

First claim

What is claimed is:

1. An apparatus for delivering tumor treating fields, the apparatus comprising:
a plurality of sets of electrode elements that are configured to impose tumor treating fields in a treatment area of a person's body, wherein each of the sets of electrode elements is configured for implantation within the person's body;
a plurality of temperature sensors configured for implantation within the person's body and positioned with respect to the sets of electrode elements to measure a temperature at each of the sets of electrode elements;
a circuit configured for implantation within the person's body configured for collecting temperature measurements from the plurality of temperature sensors; and
an AC voltage generator configured for implantation within the person's body and configured to apply an AC voltage across the plurality of sets of electrode elements and control a current that is applied to the plurality of sets of electrode elements based on signals from the plurality of temperature sensors so that the electrode elements do not overheat.

2. The apparatus of claim 1 , further comprising an inductively coupled circuit configured for implantation within the person's body and configured to power the AC voltage generator.

3. The apparatus of claim 1 , further comprising a battery configured for implantation within the person's body and configured to power the AC voltage generator.

4. The apparatus of claim 3 , further comprising an inductively coupled circuit configured for implantation within the person's body and configured to charge the battery.

5. The apparatus of claim 1 , wherein each of the sets of electrode elements comprises a plurality of capacitively coupled electrode elements, and wherein each of the electrode elements comprises a conductive plate with a flat face, with a dielectric layer disposed on the flat face of the conductive plate.

6. The apparatus of claim 5 , wherein each of the capacitively coupled electrode elements comprises a ceramic disc.

7. The apparatus of claim 1 , wherein each of the temperature sensors comprises a thermistor.

8. The apparatus of claim 1 , wherein the plurality of sets of electrode elements, the plurality of temperature sensors, the circuit, and the AC voltage generator are all implanted in the person's body.

9. An apparatus for delivering tumor treating fields, the apparatus comprising:
a plurality of sets of electrode elements that are configured to impose tumor treating fields in a treatment area of a person's body, wherein each of the sets of electrode elements is configured for implantation within the person's body;
a plurality of temperature sensors configured for implantation within the person's body and positioned to measure a temperature at each of the sets of electrode elements;
an AC voltage generator configured for implantation within the person's body and configured to apply an AC voltage across the plurality of sets of electrode elements and control a current that is applied to the plurality of sets of electrode elements based on signals from the plurality of temperature sensors so that the electrode elements do not overheat.

10. The apparatus of claim 9 , further comprising an inductively coupled circuit configured for implantation within the person's body and configured to power the AC voltage generator.

11. The apparatus of claim 9 , further comprising a battery configured for implantation within the person's body and configured to power the AC voltage generator.

12. The apparatus of claim 11 , further comprising an inductively coupled circuit configured for implantation within the person's body and configured to charge the battery.

13. The apparatus of claim 9 , wherein each of the sets of electrode elements comprises a plurality of capacitively coupled electrode elements, and wherein each of the electrode elements comprises a conductive plate with a flat face, with a dielectric layer disposed on the flat face of the conductive plate.

14. The apparatus of claim 13 , wherein each of the capacitively coupled electrode elements comprises a ceramic disc.

15. The apparatus of claim 9 , wherein each of the temperature sensors comprises a thermistor.

16. The apparatus of claim 9 , wherein the plurality of sets of electrode elements, the plurality of temperature sensors, and the AC voltage generator are all implanted in the person's body.

17. The apparatus of claim 1 , wherein one or more electrode element in each set of electrode elements has a temperature sensor associated with it.

18. The apparatus of claim 1 , wherein each electrode element in each set of electrode elements has a temperature sensor associated with it.

19. The apparatus of claim 9 , wherein one or more electrode element in each set of electrode elements has a temperature sensor associated with it.

20. The apparatus of claim 9 , wherein each electrode element in each set of electrode elements has a temperature sensor associated with it.

21. The apparatus of claim 17 , wherein the AC voltage generator is configured to control a current that is applied to each individual electrode element based on signals from the plurality of temperature sensors so that the electrode elements do not overheat.

22. The apparatus of claim 19 , wherein the AC voltage generator is configured to control a current that is applied to each individual electrode element based on signals from the plurality of temperature sensors so that the electrode elements do not overheat.

Assignees

• Novocure Gmbh

Inventors

• Wasserman Yoram
• Bomzon Zeev
• Hershkovich Hadas Sara
• Naveh Ariel
• Giladi Moshe
• Kirson Eilon
• Bar-Tal Golan
• VOLOSHIN-SELA Tali

Classifications

• A61B18/1233

  with circuits for assuring patient safety · CPC title

• A61N1/36002 Primary

  Cancer treatment, e.g. tumour · CPC title

• A61B2018/00321

  Head or parts thereof · CPC title

• A61B2018/00654

  with individual control of each of a plurality of energy emitting elements · CPC title

• A61B2018/00797

  measured by multiple temperature sensors · CPC title