Sugar amides and mixtures thereof
US-2024409523-A1 · Dec 12, 2024 · US
Oral care compositions containing deoxy sugar antimetabolites
US11471394B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11471394-B2 |
| Application number | US-202016884958-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 27, 2020 |
| Priority date | Mar 15, 2013 |
| Publication date | Oct 18, 2022 |
| Grant date | Oct 18, 2022 |
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Abstract
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Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.
First claim
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The invention claimed is: 1. A method of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in the oral cavity of a subject comprising administering to the subject an oral care composition comprising a deoxy sugar antimetabolite with no additional antibacterial agent and an orally acceptable carrier, wherein the deoxy sugar antimetabolite is present in the composition at a concentration of from 0.005% to 0.7% based on the total weight of the composition, wherein bacteria is decreased by less than 5% and biofilm is inhibited by at least 25%, and wherein the deoxy sugar antimetabolite is selected from the group consisting of 6-deoxy-D-glucose, 2-fluoro-2-deoxy-D-glucose, 2-amino-2-deoxy-D-mannosamine, and mixtures thereof. 2. The method of claim 1 , wherein the deoxy sugar antimetabolite is selected from the group consisting of 6-deoxy-D-glucose, 2-fluoro-2-deoxy-D-glucose, and mixtures thereof. 3. The method of claim 1 , wherein the deoxy sugar antimetabolite is 2-amino-2-deoxy-D-mannosamine. 4. The method of claim 1 , wherein the biofilm efficiency is at least 1000%. 5. The method according to claim 1 , wherein the method comprises treats a disease condition of the oral cavity by inhibiting microbial biofilm formation and/or degrading a microbial biofilm in the oral cavity which is selected from the group consisting of dental plaque, tooth decay, periodontal disease and gingivitis. 6. The method according to claim 1 , wherein the biofilm is formed from one or more species of bacteria selected from Actinomyces viscosus, Actinomyces naeslundii, Lactobacillus casei, Streptococcus oralis, Fusobacterium nucleatum and Veillonella parvula , and Porphyromonas gingivalis. 7. The method of claim 1 , wherein the deoxy sugar antimetabolite is 6-deoxy-D-glucose. 8. The method of claim 1 , wherein the deoxy sugar antimetabolite is 2-fluoro-2-deoxy-D-glucose. 9. The method of claim 1 , wherein the deoxy sugar antimetabolite is present in the composition at a concentration of from 0.005% to 0.5% based on the total weight of the composition. 10. The method of claim 1 , wherein the deoxy sugar antimetabolite is present in the composition at a concentration of from 0.008% to 0.3% based on the total weight of the composition.
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- What does patent US11471394B2 cover?
- Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.
- Who is the assignee on this patent?
- Colgate Palmolive Co, The Forsyth Inst
- What technology area does this patent fall under?
- Primary CPC classification A61K8/60. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).