RNA determinants for distinguishing between bacterial and viral infections

Patent metadata

Field	Value
Publication number	US-11466331-B2
Application number	US-201716081906-A
Country	US
Kind code	B2
Filing date	Mar 2, 2017
Priority date	Mar 3, 2016
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of a determinant which is set forth in Tables 1 or 2 in a sample derived from the subject, wherein said amount is indicative of the infection type.

First claim

What is claimed is:

1. A method of treating a symptom of an infection caused by a virus, in a subject comprising:
(a) measuring the amount of Junction Plakoglobin (JUP) RNA in a sample derived from the subject, so as to confirm that the subject has a viral disease, wherein when said amount is above the amount that is present in a sample of a subject that does not have a viral infection, it is confirmed that the subject has a viral infection; and
(b) treating the subject with an antiviral agent, thereby treating the symptom of the infection of the subject.

2. The method of claim 1 further comprising analyzing the expression level of CRP polypeptide or TRAIL polypeptide in said sample.

3. The method of claim 1 , further comprising measuring the amount of interferon, alpha-inducible protein 27 (IFI27) RNA in said sample.

4. The method of claim 1 , wherein no more than 20 RNA determinants are measured.

5. The method of claim 1 , wherein no more than 5 RNA determinants are measured.

6. The method of claim 1 , wherein the sample is whole blood or a fraction thereof.

7. The method of claim 6 , wherein said fraction comprises cells selected from the group consisting of lymphocytes, monocytes and granulocytes.

8. The method of claim 6 , wherein said fraction comprises serum or plasma.

9. The method of claim 1 , wherein the infection is a respiratory infection.

Assignees

• Memed Diagnostics Ltd

Inventors

• Oved Kfir
• Eden Eran
• Boico Olga
• Kronenfeld Gali
• Navon Roy
• Cohen-Dotan Assaf
• Simon Einav

Classifications

• C12Q1/70 Primary

  involving virus or bacteriophage {(immunoassay for viruses G01N33/56983)} · CPC title

• C12Q2600/158

  Expression markers · CPC title

• C12Q1/00 Primary

  Measuring or testing processes involving enzymes, nucleic acids or microorganisms (measuring or testing apparatus with condition measuring or sensing means, e.g. colony counters, C12M1/34); Compositions therefor; Processes of preparing such compositions · CPC title

• G01N33/56994

  Herpetoviridae, e.g. cytomegalovirus, Epstein-Barr virus · CPC title

• G01N33/56983

  Viruses · CPC title