Neural interrogation platform

Patent metadata

Field	Value
Publication number	US-11464964-B2
Application number	US-201916530619-A
Country	US
Kind code	B2
Filing date	Aug 2, 2019
Priority date	Aug 3, 2018
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

A system includes spatially isolated nodes proximal to a cortical surface or spinal cord, a telemetric antenna array located above the dura, the telemetric antenna array configured to provide power to and exchange data with the spatially isolated nodes, and a power and data distribution unit configured to power the spatially isolated nodes, aggregate recorded data, send the aggregated recorded data and commands through a wireless link.

First claim

What is claimed is:

1. A system comprises:
implantable spatially isolated untethered self-contained nodes configured and sized to be located below a dura of a cortical surface or spinal cords each of the implantable spatially isolated untethered self-contained nodes implementing one of a plurality of probe types, the probe types including micro-electrode arrays, micro-ECoG grids, deep brain electrodes and others,
each of the implantable spatially isolated untethered self-contained nodes configured to record from or stimulate through a plurality of electrodes,
each of the implantable spatially isolated untethered self-contained nodes comprising onboard logic configured to process electrical signals recorded from individual channels and deliver stimulation pulses to the individual channels, wherein each node has a capacity of a fifty channel maximum of neural data sampled at a sampling rate of at least 15 ksps per channel to capture single unit neural activity;
a telemetric antenna array configured to be located epidurally, the telemetric antenna array using inductive coupling to provide power to and exchange data with the implantable spatially isolated untethered self-contained nodes wirelessly over a thickness of the dura, eliminating issues of coupling distance; and
a power and data distribution unit configured to be located epidurally and to power the implantable spatially isolated untethered self-contained nodes, aggregate recorded data, send the aggregated recorded data and commands through a wireless link to an external controller, wherein power transfer efficiency is consistent for up to 6 mm of node movement.

2. The system of claim 1 , wherein each of the implantable spatially untethered self-contained isolated nodes comprises reconfigurable logic.

3. The system of claim 2 , wherein the logic is data analysis logic.

4. The system of claim 2 , wherein the logic is data compression logic.

5. The system of claim 2 , wherein the logic is closed loop stimulation logic.

6. The system of claim 2 , wherein the logic is configured to implement power saving control schemes.

7. The system of claim 1 , wherein each of the implantable spatially untethered self-contained isolated nodes is encapsulated in a package that is RF and optically transparent and robust to ionic diffusion, making a low profile hermetic seal suitable for long term implants.

8. The system of claim 1 , wherein a node implements a microelectrode array.

9. The system of claim 1 , wherein a node implements a micro-ECoG grid.

10. A method comprising:
providing the system of claim 1 ; and
recording data from the implantable spatially isolated untethered self-contained nodes untethered from external electronics using the telemetric antenna array to wirelessly power and regulate the implantable spatially isolated untethered self-contained nodes.

11. The method of claim 10 , further comprising sending and updating stimulation commands over a wireless link to the implantable spatially isolated untethered self-contained nodes.

12. The method of claim 10 , wherein the telemetric antenna array resides above the dura and conforms to a cortical surface.

Assignees

• Univ Brown

Inventors

• Borton David A
• Powell Marc

Classifications

• A61B5/4064

  Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369) · CPC title

• A61N1/36028

  for aversion therapy · CPC title

• A61N1/0534 Primary

  Electrodes for deep brain stimulation · CPC title

• A61N1/0456

  Specially adapted for transcutaneous electrical nerve stimulation [TENS] · CPC title

• A61N1/36125

  Details of circuitry or electric components · CPC title