Fruit or vegetable pomace composition and use as blood glucose modulator and anti-diabetic agent

Patent metadata

Field	Value
Publication number	US-11464820-B2
Application number	US-202016783962-A
Country	US
Kind code	B2
Filing date	Feb 6, 2020
Priority date	Oct 26, 2015
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

Methods of improving mammalian carbohydrate metabolism and treating, preventing, or halting the progression of type 2 diabetes mellitus involve the consumption of a nutritional composition containing fruit or vegetable pomace. The pomace is produced from native plant tissue and contains a mixture of soluble and insoluble fiber. Periodic consumption of the composition normalizes blood glucose concentration and controls body weight.

First claim

The invention claimed is:

1. A nutritional composition comprising an amount of carrot pomace that is therapeutically effective for maintaining or for achieving a normal blood glucose concentration in response to a diabetogenic diet in a mammalian subject in need thereof, wherein the therapeutically effective amount of carrot pomace comprises non-denatured soluble fiber—insoluble fiber complexes.

2. The nutritional composition of claim 1 , wherein the carrot pomace comprises non-denatured pectin—cellulose type complexes.

3. The nutritional composition of claim 1 , wherein the weight ratio of soluble to insoluble fiber in the carrot pomace is from about 1:1 to about 1:3.

4. The nutritional composition of claim 1 , wherein the insoluble fiber is selected from the group consisting of cellulose, hemicellulose, lignin, and combinations thereof.

5. The nutritional composition of claim 1 , wherein the soluble fiber comprises pectin.

6. The nutritional composition of claim 1 , wherein the carrot pomace is produced from carrots by a method comprising heat treatment, juice extraction, drying, and grinding.

7. The nutritional composition of claim 6 , wherein the carrot pomace is produced by a method comprising heat treatment sufficient to raise the carrot tissue to a temperature in the range from about 120° F. to about 200° F.

8. The nutritional composition of claim 6 , wherein the carrot pomace is produced by a method comprising release of at least 40% of the carrot weight as juice, the juice containing at least 3.5 wt % sugar.

9. The nutritional composition of claim 6 , wherein the carrot pomace is produced by a method that does not include alkaline treatment, bleach treatment, or fiber-denaturing heat treatment.

10. The nutritional composition of claim 1 , wherein the nutritional composition is selected from the group consisting of foods, reduced carbohydrate foods, pet foods, beverages, reduced carbohydrate beverages, dietary supplements, nutraceuticals, dietary formulations, and reduced carbohydrate dietary formulations.

11. The nutritional composition of claim 1 , wherein the subject is human.

12. The nutritional composition of claim 11 , wherein the human has or is at risk of developing type 2 diabetes or obesity and/or wherein the subject has or is at risk of developing hyperlipidemia, hypercholesterolemia, and/or elevated triglycerides.

13. The nutritional composition of claim 12 , wherein the human has or is at risk of developing type 2 diabetes or obesity, and wherein the nutritional composition is also suitable for use in promoting weight loss in the subject and/or also suitable for use in delaying the progression or onset of diabetes in the subject.

14. The nutritional composition of claim 11 , wherein the nutritional composition is also suitable for use in lowering plasma cholesterol and/or plasma triglycerides and/or also suitable for use in maintaining or improving a health-promoting intestinal microbiome in response to a diabetogenic diet in the subject.

15. The nutritional composition of claim 1 , wherein the subject is a house pet or livestock animal.

16. The nutritional composition of claim 1 , wherein the carrot pomace comprises from about 10 wt % to about 50 wt % soluble fiber.

17. The nutritional composition of claim 16 , wherein the carrot pomace comprises from about 15 wt % to about 30 wt % soluble fiber.

18. The nutritional composition of claim 1 , wherein the carrot pomace comprises comminuted particles from 30 to 60-mesh.

19. The nutritional composition of claim 6 , wherein said grinding comprises passing the dried pomace through a grinding mill to produce comminuted particles from 30 to 60-mesh.

20. The nutritional composition of claim 6 , wherein said heat treatment is sufficient to denature pectinase found in the carrot tissue.

Assignees

• Univ Brandeis

Inventors

• Hayes Kenneth C
• Perlman Daniel

Classifications

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61K36/23 Primary

  Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin · CPC title

• A23K20/163

  Sugars; Polysaccharides · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title