Use of an N-substituted pyridyl benzisoselazolone compound

Patent metadata

Field	Value
Publication number	US-11464765-B2
Application number	US-202117402006-A
Country	US
Kind code	B2
Filing date	Aug 13, 2021
Priority date	Feb 24, 2020
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

Disclosed is a use of an N-substituted pyridyl benzisoselazolone compound. The use is particularly a use in the preparation of a medicament for treating and/or preventing a disease caused by coronavirus. The present disclosure surprisingly found that the N-substituted pyridyl benzisoselazolone compound, such as ebselen, can significantly inhibit the activity of the main protease of a coronavirus and the intracellular replication capability of SARS-CoV-2, which can be used for treating a disease caused by coronavirus.

First claim

What is claimed is:

1. A method for treating a disease caused by coronavirus in an animal suffering from coronavirus infection, comprising: administering an effective amount of an N-substituted benzisoselazolone compound or a pharmaceutical composition comprising the same to the animal, wherein the N-substituted benzisoselazolone compound is represented by general formula I as follows:

wherein in the general formula I, R 1 is selected from hydrogen, halogen, linear or branched C 1 -C 4 alkyl group or alkoxy; and R 1 is substituted at 3-, 4-, 5- or 6-position;
R 2 is selected from hydrogen, halogen, linear or branched C 1 -C 4 alkyl group or alkoxy;
X represents a carbon atom; and
wherein the coronavirus is SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-HKU1, HCoV-NL63, HCoV-OC43, HCoV-229E, PDCoV, FIPV or IBV.

2. The method of claim 1 , wherein the animal is a mammal or an avian;
or, the pharmaceutical composition is in an oral dosage form;
or, the pharmaceutical composition is a cold medicine or a veterinary medicine.

3. The method of claim 1 , wherein the N-substituted pyridyl benzisoselazolone compound is a represented by the formula as follows:

4. The method of claim 2 , wherein the mammal comprises human, swine and feline.

Assignees

• Univ Shanghai Technology

Inventors

• Yang Haitao
• Jin Zhenming
• Yang Xiuna
• Zhao Yao
• Rao Zihe

Classifications

• A61P31/14

  for RNA viruses · CPC title

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• A61K31/095

  Sulfur, selenium, or tellurium compounds, e.g. thiols · CPC title

• C07D421/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• A61K31/41 Primary

  having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole · CPC title