Myocardial analysis apparatus and myocardial excitation detection apparatus

Patent metadata

Field	Value
Publication number	US-11464441-B2
Application number	US-202016829858-A
Country	US
Kind code	B2
Filing date	Mar 25, 2020
Priority date	Mar 30, 2015
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

A myocardial excitation complementation/visualization apparatus includes an acquiring section that acquires intracardiac electrocardiograms of a subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes, a processing section that performs a computation for completing and visualizing a state of excitation in a myocardium of the subject based on the intracardiac electrocardiograms, and a displaying section that displays the state of excitation in the myocardium of the subject based on an output of the processing section. The processing section includes a first generating section, a correcting section, a second generating section, and a third generating section. The displaying section displays a change of the state of excitation in the myocardium of the subject based on the visualized data.

First claim

What is claimed is:

1. A method of a myocardial analysis apparatus visualizing a state of excitation in a myocardium of a subject, the method comprising:
acquiring intracardiac electrocardiograms of the subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes;
performing a computation for completing and visualizing the state of excitation in the myocardium of the subject based on the intracardiac electrocardiograms; and
outputting the state of excitation in the myocardium of the subject based on an output of the performing the computation,
wherein the performing the computation comprises:
with respect to each of the plurality of intracardiac electrocardiograms that are recorded by the plurality of electrodes of the recording unit, generating a pseudo action potential waveform;
performing a correction for equalizing amplitudes of unit waveforms contained in the action potential waveforms;
with respect to each of the action potential waveforms that are corrected, generating a shifted waveform that is different in time phase from the action potential waveform; and
preparing a phase portrait based on each of the action potential waveforms that are corrected, and the shifted waveform corresponding to the action potential waveform, and generating visualized data indicating the state of excitation in the myocardium of the subject, based on the phase portraits, and
wherein the outputting comprises outputting a change of the state of excitation in the myocardium of the subject based on the visualized data.

2. The method according to claim 1 , wherein the shifted waveform is a waveform which is different in time phase by N+(¼) of a mean action potential duration from the action potential waveform, and
N is 0 or a positive integer.

3. The method according to claim 1 , further comprising:
when the pseudo action potential waveform is to be generated, detecting a unit waveform in the pseudo action potential waveform by using a shortest cycle length which is obtained by adding a shortest diastolic interval and shortest action potential duration in an ideal model of a unit waveform contained in the action potential waveform of the myocardium.

4. The method according to claim 1 , wherein performing the correction comprises performing the correction based on relationships between a diastolic interval and action potential duration in an ideal model of a unit waveform contained in the action potential waveform of the myocardium.

5. The method according to claim 1 , wherein performing the computation comprises:
defining a virtual electrode at a position which is in the myocardium of the subject, and in which the electrodes of the recording unit are not placed, and interpolating a pseudo action potential waveform with respect to the virtual electrode, based on the action potential waveforms generated with respect to electrodes surrounding the virtual electrode; and
interpolating the pseudo action potential waveform and the shifted waveform by using a spatial interpolation technique with respect to positions which are in the myocardium of the subject, and in which the electrodes of the recording unit and the virtual electrode are not placed.

6. The method according to claim 1 , further comprising:
when visualized data indicating the state of excitation in the myocardium of the subject are to be generated based on the phase portrait, in a unit waveform contained in the action potential waveform, defining a portion where the action potential exceeds a center of the phase portrait with a warm color, and a portion where the action potential is lower than the center with a cool color.

7. The method according to claim 1 , wherein performing the computation comprises:
extracting a first grid set that is configured by a predetermined number of grids, from the visualized data, and detecting a center of the first grid set as a phase singularity in a case where a total of color differences between adjacent grids in the first grid set is equal to or larger than a predetermined value, and all of predetermined colors are contained in a second grid set that is centered on the first grid set, and that is configured by grids a number of which is larger than a number of the grids in the first grid set.

8. A method of a myocardial analysis apparatus visualizing a state of excitation in a myocardium of a subject, the method comprising:
acquiring intracardiac electrocardiograms of the subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes;
performing a computation for completing and visualizing the state of excitation in a myocardium of the subject based on the intracardiac electrocardiograms;
outputting the state of excitation in the myocardium of the subject based on an output of the performing the computation; and
storing a plurality of action potential unit waveforms that are previously generated by computer simulation,
wherein the performing the computation comprises:
with respect to each of the plurality of intracardiac electrocardiograms that are recorded by the plurality of electrodes of the recording unit, generating a pseudo action potential waveform by using the action potential unit waveforms;
with respect to each of the action potential waveforms, generating a shifted waveform that is different in time phase from the action potential waveform; and
preparing a phase portrait based on each of the action potential waveforms and the shifted waveform corresponding to the action potential waveform, and generating visualized data indicating the state of excitation in the myocardium of the subject, based on the phase portraits, and
outputting a change of the state of excitation in the myocardium of the subject based on the visualized data.

9. The method according to claim 8 , wherein the shifted waveform is a waveform which is different in time phase by N+(¼) of a mean action potential duration from the action potential waveform, and
N is 0 or a positive integer.

10. The method according to claim 8 , wherein performing the computation comprises:
detecting time intervals between the unit waveforms contained in the intracardiac electrocardiogram, and sequentially selecting the action potential unit waveforms which are to be used in the production of the pseudo action potential waveform, based on relationships between a diastolic interval and action potential duration in an ideal model of a unit waveform contained in the action potential waveform of the myocardium.

11. The method according to claim 8 , wherein performing the computation comprises:
defining a virtual electrode at a position which is in the myocardium of the subject, and in which the electrodes of the recording unit are not placed, and interpolating a pseudo action potential waveform with respect to the virtual electrode, based on the action potential waveforms generated with respect to electrodes surrounding the virtual electrode; and
interpolating the pseudo action potential waveform and the shifted waveform by using a spatial interpolation technique with respect to positions which are in the myocardium of the subject, and in which the electrodes of the recording unit and the virtual electrode are not placed.

12. The method according to claim 8 , further comprising:
when visualized data indicating the state of excitation in the myocardium of the subject are to be generated based on the phase portrait, in an action potential unit waveforms contained in the action potential waveform, defining a portion where the action potential exceeds a center of the phase portrait with a warm color, and a portion where th

Assignees

• Univ Shiga Medical Science
• Nihon Kohden Corp
• Tsuchiya Takeshi
• Nat Cerebral & Cardiovascular Ct

Inventors

• Ashihara Takashi
• Takizawa Koji
• Nishihara Tatsuo
• Suzuki Nobuhiro
• Iwanaga Yuuho
• Ota Akio
• Tsuchiya Takeshi
• Nakazawa Kazuo
• Inada Shin

Classifications

• A61B5/28

  for electrocardiography [ECG] · CPC title

• A61B5/349

  Detecting specific parameters of the electrocardiograph cycle · CPC title

• A61B5/02

  Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow · CPC title

• A61B5/352

  Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval · CPC title

• A61B5/322

  Physical templates or devices for measuring ECG waveforms, e.g. electrocardiograph rulers or calipers · CPC title